CHICK:BCL6

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	BCL6 (ECO:0000250 with UniProtKB:P41182)
Protein Name(s)	B-cell lymphoma 6 protein homolog
External Links
UniProt	Q5ZM39
EMBL	AJ719545
RefSeq	NP_001012948.1
UniGene	Gga.22611
ProteinModelPortal	Q5ZM39
SMR	Q5ZM39
STRING	9031.ENSGALP00000011884
PaxDb	Q5ZM39
GeneID	424912
KEGG	gga:424912
CTD	604
eggNOG	COG5048
HOGENOM	HOG000001556
HOVERGEN	HBG004831
InParanoid	Q5ZM39
KO	K15618
PhylomeDB	Q5ZM39
NextBio	20827175
PRO	PR:Q5ZM39
Proteomes	UP000000539
GO	GO:0005634 GO:0003682 GO:0046872 GO:0043565 GO:0030036 GO:0030183 GO:0000902 GO:0006974 GO:0048821 GO:0002467 GO:0006954 GO:0043066 GO:0030308 GO:0008285 GO:0001953 GO:0048294 GO:0032764 GO:0035024 GO:0000122 GO:0045892 GO:0002829 GO:0043065 GO:0030890 GO:0051272 GO:0000060 GO:0008104 GO:0043087 GO:0050727 GO:0043380 GO:0007266 GO:0007283 GO:0006351
Gene3D	3.30.160.60
InterPro	IPR000210 IPR011333 IPR013069 IPR007087 IPR015880 IPR013087
Pfam	PF00651
SMART	SM00225 SM00355
SUPFAM	SSF54695
PROSITE	PS50097 PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051272	positive regulation of cellular component movement	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:9110977^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0048821	erythrocyte development	PMID:15661395^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0048294	negative regulation of isotype switching to IgE isotypes	PMID:10490661^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10490661^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15577913^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15659391^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15577913^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	F	Seeded From UniProt	complete
involved_in	GO:0043380	regulation of memory T cell differentiation	PMID:15240675^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11092811^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:10490843^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	P	Seeded From UniProt	complete
involved_in	GO:0035024	negative regulation of Rho protein signal transduction	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0032764	negative regulation of mast cell cytokine production	PMID:15950739^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:9171827^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:10490843^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	P	Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:14647274^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:15507530^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:11092811^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15577913^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	P	Seeded From UniProt	complete
colocalizes_with	GO:0005657	replication fork	PMID:10490843^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9632807^[14]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10898795^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:12817026^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	F	Seeded From UniProt	complete
involved_in	GO:0002829	negative regulation of type 2 immune response	PMID:10438949^[17]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0002467	germinal center formation	PMID:12354385^[18]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0001953	negative regulation of cell-matrix adhesion	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:15860730^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9110977^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15611242^[19]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12817026^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9632807^[14]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41183	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15577913^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41182	P	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 PANTHER:PTN000578061	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 PANTHER:PTN000578061	P	Seeded From UniProt	complete
involved_in	GO:0042092	type 2 immune response	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 PANTHER:PTN000578061	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 MGI:MGI:1278332 PANTHER:PTN000578151 UniProtKB:P41182 UniProtKB:Q96JB3	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 MGI:MGI:1278332 PANTHER:PTN000578151	F	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 MGI:MGI:1278332 PANTHER:PTN000578151	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107187 MGI:MGI:1278332 PANTHER:PTN000578151	F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Pixley, FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J. Cell. Sci. 118 1873-83 PubMed GONUTS page
↑ ^2.0 ^2.1 Dent, AL et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276 589-92 PubMed GONUTS page
↑ Asari, S et al. (2005) Abnormal erythroid differentiation in neonatal bcl-6-deficient mice. Exp. Hematol. 33 26-34 PubMed GONUTS page
↑ ^4.0 ^4.1 Harris, MB et al. (1999) Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol. Cell. Biol. 19 7264-75 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Phan, RT & Dalla-Favera, R (2004) The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432 635-9 PubMed GONUTS page
↑ Harris, MB et al. (2005) Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J. Biol. Chem. 280 13114-21 PubMed GONUTS page
↑ Ichii, H et al. (2004) Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J. Immunol. 173 883-91 PubMed GONUTS page
↑ ^8.0 ^8.1 Kojima, S et al. (2001) Testicular germ cell apoptosis in Bcl6-deficient mice. Development 128 57-65 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Albagli, O et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18 5063-75 PubMed GONUTS page
↑ Ohtsuka, Y et al. (2005) Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking. Mol. Immunol. 42 1453-9 PubMed GONUTS page
↑ Ye, BH et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16 161-70 PubMed GONUTS page
↑ Hasbold, J et al. (2004) Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat. Immunol. 5 55-63 PubMed GONUTS page
↑ Yu, RY et al. (2005) BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105 1777-84 PubMed GONUTS page
↑ ^14.0 ^14.1 Okabe, S et al. (1998) BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol. Cell. Biol. 18 4235-44 PubMed GONUTS page
↑ Huynh, KD et al. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14 1810-23 PubMed GONUTS page
↑ ^16.0 ^16.1 Takeda, N et al. (2003) Bcl6 is a transcriptional repressor for the IL-18 gene. J. Immunol. 171 426-31 PubMed GONUTS page
↑ Dent, AL et al. (1999) BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J. Immunol. 163 2098-103 PubMed GONUTS page
↑ Toyama, H et al. (2002) Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17 329-39 PubMed GONUTS page
↑ Li, Z et al. (2005) BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J. Immunol. 174 205-14 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15860730-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Pixley, FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J. Cell. Sci. 118 1873-83 PubMed GONUTS page

[PMID:9110977-2] 2.0 ^2.1 Dent, AL et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276 589-92 PubMed GONUTS page

[PMID:15661395-3] Asari, S et al. (2005) Abnormal erythroid differentiation in neonatal bcl-6-deficient mice. Exp. Hematol. 33 26-34 PubMed GONUTS page

[PMID:10490661-4] 4.0 ^4.1 Harris, MB et al. (1999) Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol. Cell. Biol. 19 7264-75 PubMed GONUTS page

[PMID:15577913-5] 5.0 ^5.1 ^5.2 ^5.3 Phan, RT & Dalla-Favera, R (2004) The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432 635-9 PubMed GONUTS page

[PMID:15659391-6] Harris, MB et al. (2005) Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J. Biol. Chem. 280 13114-21 PubMed GONUTS page

[PMID:15240675-7] Ichii, H et al. (2004) Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J. Immunol. 173 883-91 PubMed GONUTS page

[PMID:11092811-8] 8.0 ^8.1 Kojima, S et al. (2001) Testicular germ cell apoptosis in Bcl6-deficient mice. Development 128 57-65 PubMed GONUTS page

[PMID:10490843-9] 9.0 ^9.1 ^9.2 Albagli, O et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18 5063-75 PubMed GONUTS page

[PMID:15950739-10] Ohtsuka, Y et al. (2005) Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking. Mol. Immunol. 42 1453-9 PubMed GONUTS page

[PMID:9171827-11] Ye, BH et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16 161-70 PubMed GONUTS page

[PMID:14647274-12] Hasbold, J et al. (2004) Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat. Immunol. 5 55-63 PubMed GONUTS page

[PMID:15507530-13] Yu, RY et al. (2005) BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105 1777-84 PubMed GONUTS page

[PMID:9632807-14] 14.0 ^14.1 Okabe, S et al. (1998) BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol. Cell. Biol. 18 4235-44 PubMed GONUTS page

[PMID:10898795-15] Huynh, KD et al. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14 1810-23 PubMed GONUTS page

[PMID:12817026-16] 16.0 ^16.1 Takeda, N et al. (2003) Bcl6 is a transcriptional repressor for the IL-18 gene. J. Immunol. 171 426-31 PubMed GONUTS page

[PMID:10438949-17] Dent, AL et al. (1999) BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J. Immunol. 163 2098-103 PubMed GONUTS page

[PMID:12354385-18] Toyama, H et al. (2002) Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17 329-39 PubMed GONUTS page

[PMID:15611242-19] Li, Z et al. (2005) BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J. Immunol. 174 205-14 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

CHICK:BCL6

Contents

Annotations

Notes

References

a

b

c

d

e

g

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools