PMID:15950739

Citation	Ohtsuka, Y, Arima, M, Fujimura, L, Li, H, Sakamoto, A, Okamoto, Y and Tokuhisa, T (2005) Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking. Mol. Immunol. 42:1453-9
Abstract	Bcl6-deficient (Bcl6-/-) mice displayed Th2 type inflammation, which caused by abnormality of non-lymphoid cells. However, initiators for the Th2 type inflammation were not clear. In order to elucidate the initiators, we investigated property and function of mast cells derived from Bcl6-/- mice. Mast cells were developed from bone marrow cells cultured with IL-3 (BMMCs). Although the development of BMMCs from Bcl6-/- mice was similar to that from wild-type mice, proliferation of Bcl6-/- BMMCs stimulated with IL-3 was slightly lower than that of wild-type BMMCs. When these BMMCs were stimulated by FcepsilonRI/IgE cross-linking, Bcl6-/- BMMCs produced Th2 cytokines more than wild-type BMMCs did. Thus, Bcl6-/- mast cells are one of the initiators for Th2 type inflammation in Bcl6-/- mice, and Bcl6 may be a molecular target for Th2 type allergic diseases.
Links	PubMed Online version:10.1016/j.molimm.2005.01.011
Keywords	Animals; Antibodies, Monoclonal/pharmacology; Bone Marrow Cells/immunology; Cell Proliferation; Cell Survival; Cytokines/genetics; Cytokines/metabolism; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/immunology; Dinitrophenols/pharmacology; Immunoglobulin E/immunology; Mast Cells/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-kit/immunology; RNA, Messenger/metabolism; Receptors, IgE/immunology; Serum Albumin/pharmacology; Th2 Cells/immunology; beta-N-Acetylhexosaminidases/metabolism
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.