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PMID:9171827
| Citation |
Ye, BH, Cattoretti, G, Shen, Q, Zhang, J, Hawe, N, de Waard, R, Leung, C, Nouri-Shirazi, M, Orazi, A, Chaganti, RS, Rothman, P, Stall, AM, Pandolfi, PP and Dalla-Favera, R (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16:161-70 |
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| Abstract |
Structural alterations of the promoter region of the BCL-6 proto-oncogene represent the most frequent genetic alteration associated with non-Hodgkin lymphoma, a malignancy often deriving from germinal-centre B cells. The BCL-6 gene encodes a zinc-finger transcriptional repressor normally expressed in both B cells and CD4+ T cells within germinal centres, but its precise function is unknown. We show that mice deficient in BCL-6 displayed normal B-cell, T-cell and lymphoid-organ development but have a selective defect in T-cell-dependent antibody responses. This defect included a complete lack of affinity maturation and was due to the inability of follicular B cells to proliferate and form germinal centres. In addition, BCL-6-deficient mice developed an inflammatory response in multiple organs characterized by infiltrations of eosinophils and IgE-bearing B lymphocytes typical of a Th2-mediated hyperimmune response. Thus, BCL-6 functions as a transcriptional switch that controls germinal centre formation and may also modulate specific T-cell-mediated responses. Altered expression of BCL-6 in lymphoma represents a deregulation of the pathway normally leading to B cell proliferation and germinal centre formation. |
| Links |
PubMed Online version:10.1038/ng0697-161 |
| Keywords |
Animals; B-Lymphocytes/cytology; Bacterial Infections/genetics; Cell Differentiation; Cell Division; DNA-Binding Proteins/genetics; Germ Cells; Inflammation/genetics; Lymphoid Tissue/cytology; Mice; Mice, Knockout; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-6; Th2 Cells/cytology; Transcription Factors/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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