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PMID:12354385
| Citation |
Toyama, H, Okada, S, Hatano, M, Takahashi, Y, Takeda, N, Ichii, H, Takemori, T, Kuroda, Y and Tokuhisa, T (2002) Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17:329-39 |
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| Abstract |
After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl6-deficient B cells, which cannot develop germinal centers, differentiated into IgM and IgG1 memory B cells in the spleen but barely differentiated into long-lived IgG1 antibody-forming cells in the bone marrow. Mutation in the V-heavy gene was null in these memory B cells. Therefore, Bcl6 and germinal center formation are essential for somatic hypermutation, and generation of memory B cells can occur independently of germinal center formation, somatic hypermutation, and Ig class switching. |
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| Keywords |
Adoptive Transfer; Animals; B-Lymphocyte Subsets/immunology; Bone Marrow/immunology; Bone Marrow Cells/cytology; Bone Marrow Cells/immunology; Cell Differentiation; Cell Lineage; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Genes, Immunoglobulin; Germinal Center/cytology; Germinal Center/immunology; Homeodomain Proteins/genetics; Immunization; Immunoglobulin Class Switching; Immunoglobulin G/biosynthesis; Immunoglobulin Heavy Chains/genetics; Immunoglobulin M/biosynthesis; Immunoglobulin Variable Region/genetics; Immunologic Memory/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-bcl-6; Radiation Chimera; Somatic Hypermutation, Immunoglobulin; Specific Pathogen-Free Organisms; Spleen/cytology; Spleen/immunology; Transcription Factors/deficiency; Transcription Factors/genetics; Transcription Factors/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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