User:Stanto81

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	SCHPO:DCR1	2013-03-26 12:34:04 CDT	GO:0010629 negative regulation of gene expression (P)	PMID:17981703	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4. Shows the relative protein expression level is increased in the Dcr1 knockout strain when compared to the wild-type strain. Lower protein expression is indicative of lower gene expression.	challenge
acceptable	MOUSE:MTM1	2013-03-30 12:05:40 CDT	GO:0046716 muscle cell homeostasis (P)	PMID:23390130	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2A,2B. Shows mutagenesis of Mtm1 leads to lower muscle weight and myofiber size.	challenge
updatedbyinstructor	HUMAN:INSL3	2013-04-09 10:56:03 CDT	GO:0010634 positive regulation of epithelial cell migration (P)	PMID:23539510	ECO:0000314 direct assay evidence used in manual assertion	Figure 3. Shows significant higher scratch closure rate of corneal an conjuctival epithelial cells. Under the effects of migration inhibitors scratch closure could not be induced. Under the effects of cell proliferation inhibitors scratch closure was unaffected.	challenge
acceptable	HUMAN:INSL3	2013-04-09 11:12:57 CDT	GO:0090303 positive regulation of wound healing (P)	PMID:23539510	ECO:0000314 direct assay evidence used in manual assertion	Figure 5. Shows accelerated corneal wound healing after alkali burning. Higher concentrations of INSL3 correlate with quicker healing.	challenge
acceptable	HUMAN:CP17A	2013-04-09 12:10:27 CDT	GO:0004508 steroid 17-alpha-monooxygenase activity (F)	PMID:22170710	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3C. H44L, misense mutation in cytochrome b5 gene have severe deficiency in 17, 20 lyase activity compared to wild-type.	challenge
requireschanges	MOUSE:SMCA4	2013-04-09 13:13:35 CDT	GO:0060805 negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter (P)	PMID:20485553	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1. Shows Brg1 is required for Oct4 mRNA repression. Transcriptional regulation. Brg1 knockouts have higher levels of Oct4 mRNA.	challenge

acceptable:4
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Stanto81

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Alana.Cheplowitz, Team Gene Hackman	STRCH:Q934F8	GO:0043581 - obsolete mycelium development (P)	PMID:22309453	ECO:0000316 genetic interaction evidence used in manual assertion	challenge	C: 3
requireschanges	JC, Team JCML	SOLTU:Q9FEN7	GO:1901857 - positive regulation of cellular respiration (P)	PMID:18842826	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Stanto81, Team Bringin back Fanny Packs	HUMAN:INSL3	GO:0010634 - positive regulation of epithelial cell migration (P)	PMID:23539510	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2 fixed by Stanto81

1 annotations fixed by Stanto81

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