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Category:Team Bringin back Fanny Packs

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesMOUSE:SMCA4Stanto81, Team Bringin back Fanny Packs2013-04-09 13:13:35 CDTGO:0060805 negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter (P)PMID:20485553ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1. Shows Brg1 is required for Oct4 mRNA repression. Transcriptional regulation. Brg1 knockouts have higher levels of Oct4 mRNA.

challenge
acceptableECOLI:SULAGoodnoea, Team Bringin back Fanny Packs2013-04-09 12:26:39 CDTGO:0032466 negative regulation of cytokinesis (P)PMID:9501185ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1A indicates with arrows a lack of Z ring formation when MalE-SulA is present within the cell. After mutating the SulA to SulA10 the Z rings are reconstructed and cytokinesis can resume.

challenge
acceptableHUMAN:CP17AStanto81, Team Bringin back Fanny Packs2013-04-09 12:10:27 CDTGO:0004508 steroid 17-alpha-monooxygenase activity (F)PMID:22170710ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3C. H44L, misense mutation in cytochrome b5 gene have severe deficiency in 17, 20 lyase activity compared to wild-type.

challenge
acceptableHUMAN:INSL3Stanto81, Team Bringin back Fanny Packs2013-04-09 11:12:57 CDTGO:0090303 positive regulation of wound healing (P)PMID:23539510ECO:0000314 direct assay evidence used in manual assertion

Figure 5. Shows accelerated corneal wound healing after alkali burning. Higher concentrations of INSL3 correlate with quicker healing.

challenge
updatedbyinstructorHUMAN:INSL3Stanto81, Team Bringin back Fanny Packs2013-04-09 10:56:03 CDTGO:0010634 positive regulation of epithelial cell migration (P)PMID:23539510ECO:0000314 direct assay evidence used in manual assertion

Figure 3. Shows significant higher scratch closure rate of corneal an conjuctival epithelial cells. Under the effects of migration inhibitors scratch closure could not be induced. Under the effects of cell proliferation inhibitors scratch closure was unaffected.

challenge
acceptableMOUSE:MTM1Stanto81, Team Bringin back Fanny Packs2013-03-30 12:05:40 CDTGO:0046716 muscle cell homeostasis (P)PMID:23390130ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2A,2B. Shows mutagenesis of Mtm1 leads to lower muscle weight and myofiber size.

challenge
acceptableSCHPO:DCR1Stanto81, Team Bringin back Fanny Packs2013-03-26 12:34:04 CDTGO:0010629 negative regulation of gene expression (P)PMID:17981703ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4. Shows the relative protein expression level is increased in the Dcr1 knockout strain when compared to the wild-type strain. Lower protein expression is indicative of lower gene expression.

challenge

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Pages in category "Team Bringin back Fanny Packs"

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