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HUMAN:INSL3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | INSL3 (synonyms: RLF, RLNL) | |
| Protein Name(s) | Insulin-like 3
Leydig insulin-like peptide Ley-I-L Relaxin-like factor Insulin-like 3 B chain Insulin-like 3 A chain | |
| External Links | ||
| UniProt | P51460 | |
| EMBL | S72482 X73637 AY082014 AK302780 AC005952 AC007201 CH471106 BC032810 BC053345 BC071706 BC106721 BC106722 | |
| CCDS | CCDS12365.1 CCDS58655.1 | |
| PIR | B53024 | |
| RefSeq | NP_001252516.1 NP_005534.2 | |
| UniGene | Hs.37062 | |
| PDB | 2H8B 2K6T 2K6U | |
| PDBsum | 2H8B 2K6T 2K6U | |
| ProteinModelPortal | P51460 | |
| SMR | P51460 | |
| BioGrid | 109851 | |
| STRING | 9606.ENSP00000321724 | |
| DMDM | 317373369 | |
| PaxDb | P51460 | |
| PRIDE | P51460 | |
| Ensembl | ENST00000317306 ENST00000379695 | |
| GeneID | 3640 | |
| KEGG | hsa:3640 | |
| UCSC | uc002nhm.2 uc010ebf.2 | |
| CTD | 3640 | |
| GeneCards | GC19M017928 | |
| H-InvDB | HIX0014900 | |
| HGNC | HGNC:6086 | |
| HPA | HPA028615 | |
| MIM | 146738 219050 | |
| neXtProt | NX_P51460 | |
| PharmGKB | PA29893 | |
| eggNOG | NOG80279 | |
| GeneTree | ENSGT00510000050366 | |
| HOGENOM | HOG000113077 | |
| HOVERGEN | HBG052133 | |
| InParanoid | P51460 | |
| OMA | CYSGWRD | |
| OrthoDB | EOG7P5T43 | |
| PhylomeDB | P51460 | |
| TreeFam | TF106361 | |
| Reactome | REACT_19327 REACT_21314 | |
| EvolutionaryTrace | P51460 | |
| GeneWiki | INSL3 | |
| GenomeRNAi | 3640 | |
| NextBio | 14247 | |
| PRO | PR:P51460 | |
| Proteomes | UP000005640 | |
| Bgee | P51460 | |
| CleanEx | HS_INSL3 HS_RLF | |
| Genevestigator | P51460 | |
| GO | GO:0005576 GO:0005615 GO:0048471 GO:0005158 GO:0002020 GO:0005102 GO:0007193 GO:0007267 GO:0001701 GO:0008584 GO:0043066 GO:0008285 GO:0001556 GO:0030819 GO:0008284 GO:0007283 | |
| Gene3D | 1.10.100.10 | |
| InterPro | IPR016179 IPR022353 | |
| Pfam | PF00049 | |
| SMART | SM00078 | |
| SUPFAM | SSF56994 | |
| PROSITE | PS00262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0090303 |
positive regulation of wound healing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010634 |
positive regulation of epithelial cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823966 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823966 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823966 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
| GO:0010634 |
positive regulation of epithelial cell migration |
ECO:0000314 |
P |
Figure 3. Shows significant higher scratch closure rate of corneal an conjuctival epithelial cells. Under the effects of migration inhibitors scratch closure could not be induced. Under the effects of cell proliferation inhibitors scratch closure was unaffected. |
complete | |||||
| GO:0090303 |
positive regulation of wound healing |
ECO:0000314 |
P |
Figure 5. Shows accelerated corneal wound healing after alkali burning. Higher concentrations of INSL3 correlate with quicker healing. |
complete | |||||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
PMID:8020942[5] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005158 |
insulin receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Hampel, U et al. (2013) Insulin-like factor 3 promotes wound healing at the ocular surface. Endocrinology 154 2034-45 PubMed GONUTS page
- ↑ Zhang, WJ et al. (2010) In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme. Protein J. 29 93-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Adham, IM et al. (1993) Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J. Biol. Chem. 268 26668-72 PubMed GONUTS page
- ↑ 5.0 5.1 Burkhardt, E et al. (1994) Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3). Genomics 20 13-9 PubMed GONUTS page
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