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Category:Team Gene Hackman

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableSTRCH:Q53820Alana.Cheplowitz, Team Gene Hackman2013-04-14 17:35:07 CDTGO:0043581 mycelium development (P)PMID:22309453ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3. Shows that ramR is required for aerial mycelium development on high osmolarity media in S. coelicolor

challenge
unacceptableSTRCH:Q934F8Alana.Cheplowitz, Team Gene Hackman2013-04-14 17:32:27 CDTGO:0043581 mycelium development (P)PMID:22309453ECO:0000316 genetic interaction evidence used in manual assertion

Figure 3. Shows that the rodlet layer is important for differentiation in high osmolarity media.

challenge
unacceptableSTRCH:Q7AY50Alana.Cheplowitz, Team Gene Hackman2013-04-14 17:30:11 CDTGO:0043581 mycelium development (P)PMID:22309453ECO:0000316 genetic interaction evidence used in manual assertion

Figure 3. shows that the rodlet layer is important for differentiation in high osmolarity media

challenge
acceptableYEAST:LSB1Harsharn.kaur, Team Gene Hackman2013-04-13 19:26:51 CDTGO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation (P)PMID:23577202ECO:0000314 direct assay evidence used in manual assertion

figure 2 show that purified Lsb1 and Lsb2 full-length proteins had an inhibitory activity on Las17-dependent actin polymerization in vitro. These results were further confirmed by measuring the KD constants of their interaction with Las17.

challenge
unacceptableHUMAN:P53Harsharn.kaur, Team Gene Hackman2013-04-13 16:28:03 CDTGO:0003677 DNA binding (F)PMID:23555710ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 7 shows that DNA topology influences the mutp53-driven repression on the system of BAX and MSP/MST1 promoters, regulated by mutp53s in H1299 and Saos2 cells.

challenge
unacceptableHUMAN:P53Harsharn.kaur, Team Gene Hackman2013-04-12 15:13:28 CDTGO:0003677 DNA binding (F)PMID:23555710ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3B shows that without the critical role of CTDBS hot spot mutp53 proteins R175H, R273H and R248W are unable to selectively recognize scDNA.

challenge
unacceptableHUMAN:P53Nana.Agyepong, Team Gene Hackman2013-04-11 12:02:29 CDTGO:0003677 DNA binding (F)PMID:23555710ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 A shows hot spot mutations on full lenght p53. 1 B shows that open circle DNA was not bound by p53

challenge
unacceptableSTRCO:LANSBAlana.Cheplowitz, Team Gene Hackman2013-04-11 11:59:54 CDTGO:0043581 mycelium development (P)PMID:22309453ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2a,b, and c. Shows that SapB is required for differentiation in high osmolarity media.

challenge
updatedbyinstructorHUMAN:P53Harsharn.kaur, Team Gene Hackman2013-04-11 11:23:13 CDTGO:0008285 negative regulation of cell proliferation (P)PMID:22783376ECO:0000314 direct assay evidence used in manual assertion

Figure 3A: Cell proliferation assay data was performed at 48 h to examine the effect of cytoplasmically localized wild-type p53 and the S121F mutant on cell proliferation. The data resulted with both wild-type p53 and the S121F mutant inhibiting cell proliferation.

challenge
acceptableDEIRA:SODMKristalynn.Davis, Team Gene Hackman2013-03-28 14:24:49 CDTGO:0004784 superoxide dismutase activity (F)PMID:9882685ECO:0000314 direct assay evidence used in manual assertion

Fig 3 shows no secondary to sodA mutant during ionizing radiation

challenge
acceptableDEIRA:CATAAlana.Cheplowitz, Team Gene Hackman2013-03-28 12:55:29 CDTGO:0004096 catalase activity (F)PMID:23365666ECO:0000314 direct assay evidence used in manual assertion

Figure 4A shows that dGMP increased the activity of KatA.

challenge

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Pages in category "Team Gene Hackman"

The following 4 pages are in this category, out of 4 total.


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