GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
SCHPO:DCR1
Contents
| Species (Taxon ID) | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812) | |
| Gene Name(s) | dcr1 | |
| Protein Name(s) | Protein Dicer
Cell cycle control protein dcr1 RNA interference pathway protein dcr1 Endoribonuclease dcr1 ATP-dependent helicase dcr1 | |
| External Links | ||
| UniProt | Q09884 | |
| EMBL | CU329672 | |
| PIR | T39130 | |
| RefSeq | NP_588215.2 | |
| PDB | 2L6M | |
| PDBsum | 2L6M | |
| ProteinModelPortal | Q09884 | |
| SMR | Q09884 | |
| BioGrid | 275506 | |
| STRING | 4896.SPCC188.13c.1 | |
| SwissPalm | Q09884 | |
| PaxDb | Q09884 | |
| PRIDE | Q09884 | |
| EnsemblFungi | SPCC188.13c.1 | |
| GeneID | 2538930 | |
| KEGG | spo:SPCC188.13c | |
| EuPathDB | FungiDB:SPCC188.13c | |
| PomBase | SPCC188.13c | |
| InParanoid | Q09884 | |
| KO | K11592 | |
| OMA | SFVDYYH | |
| PhylomeDB | Q09884 | |
| PRO | PR:Q09884 | |
| Proteomes | UP000002485 | |
| GO | GO:0005737 GO:0005829 GO:0000790 GO:0005719 GO:0031618 GO:0034399 GO:0005634 GO:0016442 GO:0005524 GO:0003690 GO:0003725 GO:1990188 GO:0004386 GO:0004540 GO:0004525 GO:0008270 GO:0007049 GO:0034613 GO:0007059 GO:0033562 GO:0035389 GO:0070868 GO:0010629 GO:1904595 GO:0070919 GO:0030422 GO:0090052 GO:0051570 GO:0006396 | |
| CDD | cd00079 cd00593 | |
| Gene3D | 1.10.1520.10 3.30.160.380 | |
| InterPro | IPR038248 IPR005034 IPR006935 IPR014001 IPR001650 IPR027417 IPR000999 IPR036389 | |
| Pfam | PF03368 PF00271 PF04851 PF00636 | |
| SMART | SM00487 SM00490 SM00535 | |
| SUPFAM | SSF52540 SSF69065 | |
| PROSITE | PS51327 PS51192 PS51194 PS00517 PS50142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0010629 |
negative regulation of gene expression |
ECO:0000315 |
P |
Figure 4. Shows the relative protein expression level is increased in the Dcr1 knockout strain when compared to the wild-type strain. Lower protein expression is indicative of lower gene expression. |
complete | |||||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990188 |
euchromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001843) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904595 |
positive regulation of termination of RNA polymerase II transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_at:(SO:0001637) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904595 |
positive regulation of termination of RNA polymerase II transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_at:(SO:0001272) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904595 |
positive regulation of termination of RNA polymerase II transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_at:(SO:0001217) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090052 |
regulation of chromatin silencing at centromere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070919 |
production of siRNA involved in chromatin silencing by small RNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070868 |
heterochromatin organization involved in chromatin silencing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051570 |
regulation of histone H3-K9 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035389 |
establishment of chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034613 |
cellular protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(PomBase:SPAC6F12.09) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034399 |
nuclear periphery |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033562 |
co-transcriptional gene silencing by RNA interference machinery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(PomBase:SPBC16D10.08c) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033562 |
co-transcriptional gene silencing by RNA interference machinery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033562 |
co-transcriptional gene silencing by RNA interference machinery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_at:(SO:0000286) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030422 |
production of siRNA involved in RNA interference |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016442 |
RISC complex |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0034605) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0034605) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001843) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004540 |
ribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001799) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001798) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001796) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001637) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001268) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001267) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0001263) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000296) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000286) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
coincident_with:(SO:0000253) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030422 |
production of siRNA involved in RNA interference |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0034246 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016442 |
RISC complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0034246 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0034246 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0034246 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004525 |
ribonuclease III activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0034246 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004525 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004540 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004525 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004525 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0016891 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004525 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004525 |
ribonuclease III activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016891 |
endoribonuclease activity, producing 5'-phosphomonoesters |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031047 |
gene silencing by RNA |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gobeil, LA et al. (2008) Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe. Front. Biosci. 13 2203-15 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Woolcock, KJ et al. (2012) RNAi keeps Atf1-bound stress response genes in check at nuclear pores. Genes Dev. 26 683-92 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Castel, SE et al. (2014) Dicer promotes transcription termination at sites of replication stress to maintain genome stability. Cell 159 572-83 PubMed GONUTS page
- ↑ 4.0 4.1 Volpe, TA et al. (2002) Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297 1833-7 PubMed GONUTS page
- ↑ Pisacane, P & Halic, M (2017) Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi. Nat Commun 8 15332 PubMed GONUTS page
- ↑ 6.0 6.1 Kawakami, K et al. (2012) A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA. Genes Dev. 26 1811-24 PubMed GONUTS page
- ↑ Carmichael, JB et al. (2004) ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe. Mol. Biol. Cell 15 1425-35 PubMed GONUTS page
- ↑ Sadaie, M et al. (2004) A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast. EMBO J. 23 3825-35 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Oberti, D et al. (2015) Dicer and Hsp104 function in a negative feedback loop to confer robustness to environmental stress. Cell Rep 10 47-61 PubMed GONUTS page
- ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 Woolcock, KJ et al. (2011) Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. Nat. Struct. Mol. Biol. 18 94-9 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Qian, Z et al. (2005) Expression and purification of the carboxyl terminus domain of Schizosaccharomyces pombe dicer in Escherichia coli. Protein Pept. Lett. 12 311-4 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Barraud, P et al. (2011) An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer. EMBO J. 30 4223-35 PubMed GONUTS page
- ↑ 13.0 13.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
d
e
f
h
n
- GO:0010629 ! negative regulation of gene expression
- GO:0000790 ! nuclear chromatin
- GO:0005719 ! nuclear euchromatin
- GO:0031618 ! nuclear pericentric heterochromatin
- GO:0034399 ! nuclear periphery
- GO:0004518 ! nuclease activity
- GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
p
r
- GO:0051570 ! regulation of histone H3-K9 methylation
- GO:0090052 ! regulation of pericentric heterochromatin assembly
- GO:0004525 ! ribonuclease III activity
- GO:0004540 ! ribonuclease activity
- GO:0016442 ! RISC complex
- GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic
- GO:0090501 ! RNA phosphodiester bond hydrolysis
- GO:0006396 ! RNA processing
s
