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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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SCHPO:DCR1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) dcr1
Protein Name(s) Protein Dicer

Cell cycle control protein dcr1 RNA interference pathway protein dcr1 Endoribonuclease dcr1 ATP-dependent helicase dcr1

External Links
UniProt Q09884
EMBL CU329672
PIR T39130
RefSeq NP_588215.2
PDB 2L6M
PDBsum 2L6M
ProteinModelPortal Q09884
STRING Q09884
EnsemblFungi SPCC188.13c.1
GeneID 2538930
GenomeReviews CU329672_GR
KEGG spo:SPCC188.13c
PomBase SPCC188.13c
eggNOG COG1111
KO K11592
OMA RMCLICN
OrthoDB EOG4PRWZS
NextBio 20800107
GO GO:0005829
GO:0005720
GO:0005524
GO:0003677
GO:0004386
GO:0046872
GO:0004540
GO:0004525
GO:0003723
GO:0007049
GO:0034613
GO:0031048
GO:0007059
GO:0035389
GO:0030422
GO:0090052
GO:0051983
GO:0051570
Gene3D 1.10.1520.10
InterPro IPR005034
IPR006935
IPR014001
IPR001650
IPR000999
Pfam PF03368
PF00271
PF04851
PF00636
SMART SM00487
SM00490
SM00535
SUPFAM SSF69065
PROSITE PS51327
PS51192
PS51194
PS00517
PS50142

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006935

F

Seeded From UniProt

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999

F

Seeded From UniProt

GO:0004386

helicase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded From UniProt

GO:0004386

helicase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

Seeded From UniProt

GO:0004518

nuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

F

Seeded From UniProt

GO:0004519

endonuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0255

F

Seeded From UniProt

GO:0004525

ribonuclease III activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999

F

Seeded From UniProt

GO:0004540

ribonuclease activity

PMID:15907173[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000001

IC: Inferred by Curator

GO:0008026

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650
InterPro:IPR006935

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005720

nuclear heterochromatin

GO_REF:0000001

IC: Inferred by Curator

GO:0016442

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:16823372[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006396

RNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999

P

Seeded From UniProt

GO:0006396

RNA processing

PMID:15907173[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

GO:0007059

chromosome segregation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0159

P

Seeded From UniProt

GO:0016787

hydrolase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006935

F

Seeded From UniProt

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

GO:0016891

endoribonuclease activity, producing 5'-phosphomonoesters

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005034

F

Seeded From UniProt

GO:0030422

production of siRNA involved in RNA interference

PMID:15907173[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0031047

gene silencing by RNA

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0943

P

Seeded From UniProt

GO:0031048

chromatin silencing by small RNA

PMID:15607976[3]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0034613

cellular protein localization

PMID:15372076[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0035389

establishment of chromatin silencing at silent mating-type cassette

PMID:14699070[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

GO:0051570

regulation of histone H3-K9 methylation

PMID:12193640[6]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0051983

regulation of chromosome segregation

PMID:12482946[7]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0090052

regulation of chromatin silencing at centromere

PMID:12193640[6]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

P

Seeded From UniProt

GO:0010629

negative regulation of gene expression

PMID:17981703[8]

IMP: Inferred from Mutant Phenotype

P

Figure 4. Shows the relative protein expression level is increased in the Dcr1 knockout strain when compared to the wild-type strain. Lower protein expression is indicative of lower gene expression.

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Qian, Z et al. (2005) Expression and purification of the carboxyl terminus domain of Schizosaccharomyces pombe dicer in Escherichia coli. Protein Pept. Lett. 12 311-4 PubMed GONUTS page
  2. ↑ 2.0 2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  3. ↑ Motamedi, MR et al. (2004) Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell 119 789-802 PubMed GONUTS page
  4. ↑ Sadaie, M et al. (2004) A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast. EMBO J. 23 3825-35 PubMed GONUTS page
  5. ↑ Carmichael, JB et al. (2004) ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe. Mol. Biol. Cell 15 1425-35 PubMed GONUTS page
  6. ↑ 6.0 6.1 Volpe, TA et al. (2002) Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297 1833-7 PubMed GONUTS page
  7. ↑ Provost, P et al. (2002) Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc. Natl. Acad. Sci. U.S.A. 99 16648-53 PubMed GONUTS page
  8. ↑ Gobeil, LA et al. (2008) Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe. Front. Biosci. 13 2203-15 PubMed GONUTS page
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