User:Meghan.Flannery

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	HUMAN:IL21	2012-10-03 21:26:20 CDT	GO:0005125 cytokine activity (F)	PMID:19322899	ECO:0000314 direct assay evidence used in manual assertion	Fig 3 shows that IL-21 enhances IBD NK-cell cytokine secretion	challenge
unacceptable	HUMAN:DEDD2	2012-10-05 12:59:23 CDT	GO:0006915 apoptotic process (P)	PMID:11741985	ECO:0000316 genetic interaction evidence used in manual assertion	Fig 4 shows that DEDD2 is able to induce apoptosis	challenge
acceptable	HUMAN:IL18	2012-10-19 18:58:22 CDT	GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein (P)	PMID:10903731	ECO:0000314 direct assay evidence used in manual assertion	Fig 2 shows that stimulation of NK92 and NK92Ci cell lines with IL-18 results in activation and DNA binding of STAT3	challenge
acceptable	HUMAN:5NTD	2012-11-04 12:48:54 CST	GO:0007159 leukocyte cell-cell adhesion (P)	PMID:7595232	ECO:0000314 direct assay evidence used in manual assertion	Fig 5 clearly shows that CD73 is involved in lymphocyte binding to COS cells	challenge
acceptable	HUMAN:IL21	2012-11-12 20:27:43 CST	GO:0045954 positive regulation of natural killer cell mediated cytotoxicity (P)	PMID:18005035	ECO:0000314 direct assay evidence used in manual assertion	Fig. 5 shows that IL-21 enhances the cytotoxicity of Natural Killer cells.	challenge
acceptable	HUMAN:IL21	2012-11-12 21:21:42 CST	GO:0042503 tyrosine phosphorylation of Stat3 protein (P)	PMID:12244150	ECO:0000314 direct assay evidence used in manual assertion	Fig. 6 shows that IL-21 induces tyrosine phosphorylation of Stat3.	challenge
acceptable	HUMAN:IL15	2012-11-13 20:01:42 CST	GO:0042506 tyrosine phosphorylation of Stat5 protein (P)	PMID:12244150	ECO:0000314 direct assay evidence used in manual assertion	Fig. 6 shows induction of tyrosine phosphorylation by IL-15.	challenge
acceptable	HUMAN:5NTD	2012-11-14 11:25:50 CST	GO:0008253 5'-nucleotidase activity (F)	PMID:7595232	ECO:0000314 direct assay evidence used in manual assertion	Fig. 4 shows inhibition of ecto-5'-NT activity via different anti- CD73 mAbs.	challenge
acceptable	HUMAN:TSP1	2012-11-14 20:24:59 CST	GO:0006954 inflammatory response (P)	PMID:23144964	ECO:0000314 direct assay evidence used in manual assertion	Fig. 4 shows that TSP1 enhances the production of cytokines and chemokines by human IFN-γ-differentiated macrophages.	challenge

acceptable:7
unacceptable:1
requires_changes:1
flagged:0

Annotations challenged by Meghan.Flannery

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Meghan.Flannery