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HUMAN:5NTD

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NT5E (synonyms: NT5, NTE)
Protein Name(s) 5'-nucleotidase

5'-NT Ecto-5'-nucleotidase

External Links
UniProt P21589
EMBL X55740
AK075008
AL135903
AL589666
AL589666
AL135903
U21730
AF069067
CCDS CCDS5002.1
CCDS56439.1
PIR S11032
RefSeq NP_001191742.1
NP_002517.1
UniGene Hs.153952
PDB 4H1S
4H1Y
4H2B
4H2F
4H2G
4H2I
PDBsum 4H1S
4H1Y
4H2B
4H2F
4H2G
4H2I
ProteinModelPortal P21589
SMR P21589
BioGrid 110962
DIP DIP-59992N
MINT MINT-5002487
STRING 9606.ENSP00000257770
BindingDB P21589
ChEMBL CHEMBL5957
DrugBank DB00987
DB00806
GuidetoPHARMACOLOGY 1232
DEPOD P21589
PhosphoSite P21589
DMDM 112825
MaxQB P21589
PaxDb P21589
PRIDE P21589
DNASU 4907
Ensembl ENST00000257770
ENST00000369651
GeneID 4907
KEGG hsa:4907
UCSC uc003pko.4
uc010kbr.3
CTD 4907
GeneCards GC06P086216
HGNC HGNC:8021
HPA HPA017357
MIM 129190
211800
neXtProt NX_P21589
Orphanet 289601
PharmGKB PA31804
eggNOG COG0737
GeneTree ENSGT00530000063775
HOGENOM HOG000247215
HOVERGEN HBG000026
KO K01081
OMA RVPSYDP
OrthoDB EOG7TF78T
PhylomeDB P21589
TreeFam TF323589
BioCyc MetaCyc:HS05981-MONOMER
RETL1328306-WGS:GSTH-3623-MONOMER
Reactome REACT_1023
REACT_2086
ChiTaRS NT5E
GeneWiki NT5E
GenomeRNAi 4907
NextBio 18883
PRO PR:P21589
Proteomes UP000005640
Bgee P21589
CleanEx HS_NT5E
ExpressionAtlas P21589
Genevestigator P21589
GO GO:0031225
GO:0009986
GO:0005737
GO:0070062
GO:0016020
GO:0005886
GO:0008253
GO:0046872
GO:0000166
GO:0046086
GO:0006196
GO:0016311
GO:0006259
GO:0050728
GO:0055086
GO:0006144
GO:0006195
GO:0006206
GO:0046135
GO:0044281
Gene3D 3.60.21.10
3.90.780.10
InterPro IPR008334
IPR006146
IPR006179
IPR004843
IPR029052
PANTHER PTHR11575
Pfam PF02872
PF00149
PRINTS PR01607
SUPFAM SSF55816
SSF56300
PROSITE PS00785
PS00786

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007159

leukocyte cell-cell adhesion

PMID:7595232[1]

ECO:0000314

P

Fig 5 clearly shows that CD73 is involved in lymphocyte binding to COS cells

complete
CACAO 5606

GO:0008253

5'-nucleotidase activity

PMID:7595232[1]

ECO:0000314

F

Fig. 4 shows inhibition of ecto-5'-NT activity via different anti- CD73 mAbs.

complete
CACAO 5819

involved_in

GO:0007159

leukocyte cell-cell adhesion

PMID:7595232[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

PMID:7595232[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:19581412[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:21362503[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002367)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008253

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61503
ensembl:ENSMUSP00000034992

P

Seeded From UniProt

complete

involved_in

GO:0046086

adenosine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61503
ensembl:ENSMUSP00000034992

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61503
ensembl:ENSMUSP00000034992

C

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61503
ensembl:ENSMUSP00000034992

F

Seeded From UniProt

complete

involved_in

GO:0006196

AMP catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61503
ensembl:ENSMUSP00000034992

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61503
ensembl:ENSMUSP00000034992

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006146

F

Seeded From UniProt

complete

involved_in

GO:0009166

nucleotide catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006179
InterPro:IPR008334
InterPro:IPR036907

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004843
InterPro:IPR006179
InterPro:IPR008334
InterPro:IPR036907

F

Seeded From UniProt

complete

enables

GO:0016788

hydrolase activity, acting on ester bonds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006146

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006146

F

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.5

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:2129526[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008253

5'-nucleotidase activity

PMID:2129526[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006259

DNA metabolic process

PMID:2129526[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046135

pyrimidine nucleoside catabolic process

Reactome:R-HSA-73621

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019674

NAD metabolic process

Reactome:R-HSA-196807

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006195

purine nucleotide catabolic process

Reactome:R-HSA-74259

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8940074
Reactome:R-HSA-8940070
Reactome:R-HSA-109291
Reactome:R-HSA-109278

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0031225

anchored component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0336

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Airas, L et al. (1995) CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73. J. Exp. Med. 182 1603-8 PubMed GONUTS page
  2. ↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
  3. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  6. ↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Misumi, Y et al. (1990) Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form. Eur. J. Biochem. 191 563-9 PubMed GONUTS page
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