HUMAN:IL18

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL18 (synonyms: IGIF, IL1F4)
Protein Name(s)	Interleukin-18 IL-18 Iboctadekin Interferon gamma-inducing factor IFN-gamma-inducing factor Interleukin-1 gamma IL-1 gamma
External Links
UniProt	Q14116
EMBL	D49950 AY266351 AF077611 AY044641 CR541973 CR542001 AP002007 AP002884 CH471065 BC007007 BC007461 U90434
CCDS	CCDS44731.1 CCDS58180.1
RefSeq	NP_001230140.1 NP_001553.1
UniGene	Hs.83077
PDB	1J0S 2VXT 3F62 4EEE 4EKX 4HJJ 4R6U
PDBsum	1J0S 2VXT 3F62 4EEE 4EKX 4HJJ 4R6U
ProteinModelPortal	Q14116
SMR	Q14116
BioGrid	109819
DIP	DIP-3785N
IntAct	Q14116
STRING	9606.ENSP00000280357
PhosphoSite	Q14116
DMDM	3219817
OGP	Q14116
MaxQB	Q14116
PaxDb	Q14116
PRIDE	Q14116
DNASU	3606
Ensembl	ENST00000280357 ENST00000524595 ENST00000528832
GeneID	3606
KEGG	hsa:3606
UCSC	uc001pna.2 uc009yym.2
CTD	3606
GeneCards	GC11M112013
HGNC	HGNC:5986
HPA	CAB007772 CAB027385 HPA003980
MIM	600953
neXtProt	NX_Q14116
PharmGKB	PA29802
eggNOG	NOG77229
GeneTree	ENSGT00390000001053
HOGENOM	HOG000048723
HOVERGEN	HBG000388
InParanoid	Q14116
KO	K05482
OMA	VPGHDDK
OrthoDB	EOG7SR4NN
PhylomeDB	Q14116
TreeFam	TF336297
Reactome	REACT_23950
EvolutionaryTrace	Q14116
GeneWiki	Interleukin_18
GenomeRNAi	3606
NextBio	14093
PMAP-CutDB	Q14116
PRO	PR:Q14116
Proteomes	UP000005640
Bgee	Q14116
CleanEx	HS_IL18
ExpressionAtlas	Q14116
Genevestigator	Q14116
GO	GO:0005829 GO:0005576 GO:0005615 GO:0070062 GO:0005125 GO:0001525 GO:0007267 GO:0071407 GO:0042033 GO:0042253 GO:0006955 GO:0006954 GO:0042095 GO:0042231 GO:0042094 GO:0031663 GO:0000165 GO:0030101 GO:0042104 GO:0010628 GO:0032725 GO:0050729 GO:0032729 GO:0032740 GO:0032819 GO:0042346 GO:0051142 GO:0034105 GO:0030155 GO:0030431 GO:0042088 GO:0042092
InterPro	IPR008996 IPR015529 IPR000975
PANTHER	PTHR11326
Pfam	PF00340
PIRSF	PIRSF015162
PRINTS	PR01933
SUPFAM	SSF50353

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	PMID:10903731^[1]	ECO:0000314			P		Fig 2 shows that stimulation of NK92 and NK92Ci cell lines with IL-18 results in activation and DNA binding of STAT3	complete CACAO 5399
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26656097^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70380	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21321938^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0048661) part_of:(GO:0035655) occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24615654^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07996)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21323571^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001977)	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21321938^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0007318) causally_upstream_of:(GO:0048661) part_of:(GO:0035655)	Seeded From UniProt	complete
involved_in	GO:0035655	interleukin-18-mediated signaling pathway	PMID:21321938^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0048661) occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	PMID:21321938^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0048661) part_of:(GO:0035655) occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70380	F		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70380	P		Seeded From UniProt	complete
involved_in	GO:0045630	positive regulation of T-helper 2 cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70380	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70380	P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70380	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:21321938^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:10903731^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:10653850^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000556	positive regulation of T-helper 1 cell cytokine production	PMID:10653850^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:14528293^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:14528293^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035655	interleukin-18-mediated signaling pathway	PMID:25500532^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045515	interleukin-18 receptor binding	PMID:14528293^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:25500532^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0045515	interleukin-18 receptor binding	PMID:25500532^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:25500532^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051142	positive regulation of NK T cell proliferation	PMID:19088061^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:16482511^[10]	ECO:0000305	curator inference used in manual assertion	GO:0032740	P		Seeded From UniProt	complete
involved_in	GO:0034105	positive regulation of tissue remodeling	PMID:16482511^[10]	ECO:0000305	curator inference used in manual assertion	GO:0032740	P		Seeded From UniProt	complete
involved_in	GO:0032819	positive regulation of natural killer cell proliferation	PMID:19088061^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	PMID:16482511^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:19088061^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:20027291^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:20027291^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:21147091^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	PMID:8766574^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042088	T-helper 1 type immune response	PMID:8766574^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:21147091^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0030431	sleep	PMID:11506998^[14]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97636	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:11477102^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21147091^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:11466388^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21147091^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0045630	positive regulation of T-helper 2 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0042267	natural killer cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0042095	interferon-gamma biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0035744	T-helper 1 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0035655	interleukin-18-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0032635	interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0032609	interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0030101	natural killer cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70380 ensembl:ENSMUSP00000151002	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	P		Seeded From UniProt	complete
involved_in	GO:0150078	positive regulation of neuroinflammatory response	PMID:26753638^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:9792649^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:8666798^[19] PMID:11598150^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process	PMID:10653850^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042231	interleukin-13 biosynthetic process	PMID:10227975^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042095	interferon-gamma biosynthetic process	PMID:10227975^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042094	interleukin-2 biosynthetic process	PMID:10653850^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042092	type 2 immune response	PMID:11905033^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042033	chemokine biosynthetic process	PMID:11598150^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:11598150^[20] Reactome:R-HSA-8848395 Reactome:R-HSA-8848392 Reactome:R-HSA-8848370 Reactome:R-HSA-6784160 Reactome:R-HSA-449058	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035655	interleukin-18-mediated signaling pathway	Reactome:R-HSA-9012546	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-6783783 Reactome:R-HSA-446652	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6797293 Reactome:R-HSA-449058 Reactome:R-HSA-448703	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kalina, U et al. (2000) IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J. Immunol. 165 1307-13 PubMed GONUTS page
↑ Pazos, P et al. (2015) Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Sci Rep 5 17977 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Reddy, VS et al. (2011) Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell. Physiol. 226 3303-15 PubMed GONUTS page
↑ Hamakawa, T et al. (2014) Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells. Prostate 74 590-601 PubMed GONUTS page
↑ Khan, DA et al. (2011) Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease. J. Interferon Cytokine Res. 31 561-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tominaga, K et al. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int. Immunol. 12 151-60 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kato, Z et al. (2003) The structure and binding mode of interleukin-18. Nat. Struct. Biol. 10 966-71 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Tsutsumi, N et al. (2014) The structural basis for receptor recognition of human interleukin-18. Nat Commun 5 5340 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 van de Wetering, D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int. Immunol. 21 145-53 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page
↑ ^11.0 ^11.1 van de Wetering, D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE 4 e8396 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Wu, F et al. (2011) Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells. Eur. J. Pharmacol. 654 117-21 PubMed GONUTS page
↑ ^13.0 ^13.1 Micallef, MJ et al. (1996) Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur. J. Immunol. 26 1647-51 PubMed GONUTS page
↑ Kubota, T et al. (2001) Interleukin-18 promotes sleep in rabbits and rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R828-38 PubMed GONUTS page
↑ Morel, JC et al. (2001) A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J. Biol. Chem. 276 37069-75 PubMed GONUTS page
↑ Park, CC et al. (2001) Evidence of IL-18 as a novel angiogenic mediator. J. Immunol. 167 1644-53 PubMed GONUTS page
↑ Gu, Y et al. () Role of TNF in mast cell neuroinflammation and pain. J. Biol. Regul. Homeost. Agents 29 787-91 PubMed GONUTS page
↑ Born, TL et al. (1998) Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273 29445-50 PubMed GONUTS page
↑ Ushio, S et al. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156 4274-9 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Morel, JC et al. (2001) Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation. Lab. Invest. 81 1371-83 PubMed GONUTS page
↑ ^21.0 ^21.1 Hoshino, T et al. (1999) IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J. Immunol. 162 5070-7 PubMed GONUTS page
↑ Nakanishi, K (2002) [Regulation of Th1 and Th2 immune responses by IL-18]. Kekkaku 77 87-93 PubMed GONUTS page

[PMID:10903731-1] 1.0 ^1.1 Kalina, U et al. (2000) IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J. Immunol. 165 1307-13 PubMed GONUTS page

[PMID:26656097-2] Pazos, P et al. (2015) Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Sci Rep 5 17977 PubMed GONUTS page

[PMID:21321938-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Reddy, VS et al. (2011) Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell. Physiol. 226 3303-15 PubMed GONUTS page

[PMID:24615654-4] Hamakawa, T et al. (2014) Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells. Prostate 74 590-601 PubMed GONUTS page

[PMID:21323571-5] Khan, DA et al. (2011) Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease. J. Interferon Cytokine Res. 31 561-7 PubMed GONUTS page

[PMID:10653850-6] 6.0 ^6.1 ^6.2 ^6.3 Tominaga, K et al. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int. Immunol. 12 151-60 PubMed GONUTS page

[PMID:14528293-7] 7.0 ^7.1 ^7.2 Kato, Z et al. (2003) The structure and binding mode of interleukin-18. Nat. Struct. Biol. 10 966-71 PubMed GONUTS page

[PMID:25500532-8] 8.0 ^8.1 ^8.2 ^8.3 Tsutsumi, N et al. (2014) The structural basis for receptor recognition of human interleukin-18. Nat Commun 5 5340 PubMed GONUTS page

[PMID:19088061-9] 9.0 ^9.1 ^9.2 van de Wetering, D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int. Immunol. 21 145-53 PubMed GONUTS page

[PMID:16482511-10] 10.0 ^10.1 ^10.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page

[PMID:20027291-11] 11.0 ^11.1 van de Wetering, D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE 4 e8396 PubMed GONUTS page

[PMID:21147091-12] 12.0 ^12.1 ^12.2 ^12.3 Wu, F et al. (2011) Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells. Eur. J. Pharmacol. 654 117-21 PubMed GONUTS page

[PMID:8766574-13] 13.0 ^13.1 Micallef, MJ et al. (1996) Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur. J. Immunol. 26 1647-51 PubMed GONUTS page

[PMID:11506998-14] Kubota, T et al. (2001) Interleukin-18 promotes sleep in rabbits and rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R828-38 PubMed GONUTS page

[PMID:11477102-15] Morel, JC et al. (2001) A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J. Biol. Chem. 276 37069-75 PubMed GONUTS page

[PMID:11466388-16] Park, CC et al. (2001) Evidence of IL-18 as a novel angiogenic mediator. J. Immunol. 167 1644-53 PubMed GONUTS page

[PMID:26753638-17] Gu, Y et al. () Role of TNF in mast cell neuroinflammation and pain. J. Biol. Regul. Homeost. Agents 29 787-91 PubMed GONUTS page

[PMID:9792649-18] Born, TL et al. (1998) Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273 29445-50 PubMed GONUTS page

[PMID:8666798-19] Ushio, S et al. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156 4274-9 PubMed GONUTS page

[PMID:11598150-20] 20.0 ^20.1 ^20.2 Morel, JC et al. (2001) Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation. Lab. Invest. 81 1371-83 PubMed GONUTS page

[PMID:10227975-21] 21.0 ^21.1 Hoshino, T et al. (1999) IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J. Immunol. 162 5070-7 PubMed GONUTS page

[PMID:11905033-22] Nakanishi, K (2002) [Regulation of Th1 and Th2 immune responses by IL-18]. Kekkaku 77 87-93 PubMed GONUTS page

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