HUMAN:TSP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	THBS1 (synonyms: TSP, TSP1)
Protein Name(s)	Thrombospondin-1
External Links
UniProt	P07996
EMBL	X04665 X14787 AK291639 AK304754 AB209912 AC037198 BC136469 BC136470 M25631 M14326 J04835 M99425
CCDS	CCDS32194.1
PIR	A26155
RefSeq	NP_003237.2
UniGene	Hs.164226
PDB	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
PDBsum	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
ProteinModelPortal	P07996
SMR	P07996
BioGrid	112915
DIP	DIP-1037N
IntAct	P07996
MINT	MINT-6630675
STRING	9606.ENSP00000260356
PhosphoSite	P07996
UniCarbKB	P07996
DMDM	117949802
OGP	P07996
MaxQB	P07996
PaxDb	P07996
PeptideAtlas	P07996
PRIDE	P07996
Ensembl	ENST00000260356
GeneID	7057
KEGG	hsa:7057
UCSC	uc001zkh.3
CTD	7057
GeneCards	GC15P039873
H-InvDB	HIX0038125
HGNC	HGNC:11785
HPA	CAB033678
MIM	188060
neXtProt	NX_P07996
PharmGKB	PA36497
eggNOG	NOG12793
GeneTree	ENSGT00550000074507
HOVERGEN	HBG018006
InParanoid	P07996
KO	K16857
OMA	SPWDICS
OrthoDB	EOG76QFGD
PhylomeDB	P07996
TreeFam	TF324917
Reactome	REACT_13552 REACT_163942 REACT_16888 REACT_200626
ChiTaRS	THBS1
EvolutionaryTrace	P07996
GeneWiki	Thrombospondin_1
GenomeRNAi	7057
NextBio	27597
PMAP-CutDB	P07996
PRO	PR:P07996
Proteomes	UP000005640
Bgee	P07996
CleanEx	HS_THBS1
ExpressionAtlas	P07996
Genevestigator	P07996
GO	GO:0009986 GO:0005783 GO:0009897 GO:0031012 GO:0005576 GO:0005615 GO:0070062 GO:0005577 GO:0031091 GO:0031093 GO:0016529 GO:0030141 GO:0005509 GO:0070052 GO:0070051 GO:0017134 GO:0001968 GO:0001948 GO:0008201 GO:0042802 GO:0005178 GO:0043236 GO:0030169 GO:0001786 GO:0043394 GO:0050431 GO:0000187 GO:0048266 GO:0007596 GO:0007155 GO:0007050 GO:0016477 GO:0071363 GO:0034605 GO:0071356 GO:0002544 GO:0003197 GO:0043652 GO:0030198 GO:0003417 GO:0006955 GO:0016525 GO:0002581 GO:0043066 GO:0043537 GO:0001953 GO:0010754 GO:0043154 GO:0002605 GO:2001027 GO:0010596 GO:0001937 GO:2001237 GO:0051918 GO:0040037 GO:0051895 GO:0032695 GO:0010751 GO:0010748 GO:0010757 GO:0003151 GO:0018149 GO:0030168 GO:0002576 GO:0045766 GO:0030194 GO:0043536 GO:0030335 GO:0010811 GO:0050921 GO:2000353 GO:0010595 GO:1902043 GO:0010763 GO:0043032 GO:0010759 GO:0042327 GO:0051897 GO:2000379 GO:0030511 GO:0032914 GO:0045727 GO:0042535 GO:0030823 GO:0051592 GO:0042493 GO:0034976 GO:0009749 GO:0001666 GO:0032026 GO:0009612 GO:0032570 GO:0033574 GO:0006986 GO:0002040
Gene3D	2.60.120.200 4.10.1080.10
InterPro	IPR013320 IPR000742 IPR001881 IPR013032 IPR001791 IPR028499 IPR000884 IPR003367 IPR017897 IPR008859 IPR028974 IPR001007
PANTHER	PTHR10199:SF78
Pfam	PF07645 PF00090 PF02412 PF05735 PF00093
SMART	SM00181 SM00209 SM00210 SM00214
SUPFAM	SSF103647 SSF49899 SSF82895
PROSITE	PS01186 PS50026 PS50092 PS51234 PS51236 PS01208 PS50184

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006954	inflammatory response	PMID:23144964^[1]	ECO:0000314			P		Fig. 4 shows that TSP1 enhances the production of cytokines and chemokines by human IFN-γ-differentiated macrophages.	complete CACAO 5822
enables	GO:0005201	extracellular matrix structural constituent	PMID:28327460^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002540)\|occurs_in:(CL:0002570)\|occurs_in:(CL:0002551)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)\|part_of:(CL:0002551)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:23979707^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002543)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28344315^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002371)	Seeded From UniProt	complete
involved_in	GO:1903671	negative regulation of sprouting angiogenesis	PMID:28124060^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001D69F6_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:20551380^[6]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001496)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1SS26	F	occurs_in:(UBERON:0002084)	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:24177325^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0010004)	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:24615654^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_division_of:(CL:0002622)	Seeded From UniProt	complete
involved_in	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	PMID:25660232^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:25660232^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:24615654^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23979707^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002543)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:26395742^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	adjacent_to:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:23144964^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:6341993^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[17]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:18757424^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:18726995^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070052	collagen V binding	PMID:6693501^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070051	fibrinogen binding	PMID:6693501^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051918	negative regulation of fibrinolysis	PMID:6438154^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:18757424^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q71SA3	F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:17879962^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:17413041^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:15700281^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043652	engulfment of apoptotic cell	PMID:16882710^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043236	laminin binding	PMID:6693501^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	PMID:18757424^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9304800^[28]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:17413041^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	PMID:17996481^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:9304800^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032914	positive regulation of transforming growth factor beta1 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q71SA3	P		Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	PMID:16882710^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032026	response to magnesium ion	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031091	platelet alpha granule	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:20551380^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:22261194^[30]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1SS26	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17413041^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15700281^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030194	positive regulation of blood coagulation	PMID:3997886^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	PMID:6693501^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:101549^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018149	peptide cross-linking	PMID:3997886^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:17996481^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:17996481^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:17596205^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010763	positive regulation of fibroblast migration	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35441	P		Seeded From UniProt	complete
involved_in	GO:0010757	negative regulation of plasminogen activation	PMID:6438154^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010754	negative regulation of cGMP-mediated signaling	PMID:17416590^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010751	negative regulation of nitric oxide mediated signal transduction	PMID:17416590^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	PMID:17416590^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010596	negative regulation of endothelial cell migration	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:18555217^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:2435757^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:3084490^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:18096704^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:101549^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:9304800^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:17596205^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:18674744^[38]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20551380^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005577	fibrinogen complex	PMID:3997886^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:9304800^[28]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:18757424^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:17413041^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002605	negative regulation of dendritic cell antigen processing and presentation	PMID:16882710^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	PMID:16882710^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002544	chronic inflammatory response	PMID:18674744^[38]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:17879962^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	PMID:6693501^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001953	negative regulation of cell-matrix adhesion	PMID:17416590^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:17413041^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:17996481^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:9304800^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:17413041^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	PMID:18726995^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21362503^[39]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002367)	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:18653767^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048266	behavioral response to pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35441	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18653767^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18653767^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:18726995^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:19738618^[41]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35441	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35441	C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:18726995^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35441	C		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:18940719^[42]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:21873635^[43]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031850 MGI:MGI:1101779 MGI:MGI:98738 PANTHER:PTN002565423 RGD:2378 UniProtKB:P35443	C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:21873635^[43]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98737 MGI:MGI:98738 PANTHER:PTN002468952 RGD:1310979 RGD:1588455 UniProtKB:P07996 UniProtKB:P35442	P		Seeded From UniProt	complete
involved_in	GO:2001027	negative regulation of endothelial cell chemotaxis	PMID:16150726^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:16150726^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010751	negative regulation of nitric oxide mediated signal transduction	PMID:16150726^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:8288588^[45]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001953	negative regulation of cell-matrix adhesion	PMID:16150726^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:16150726^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071636	positive regulation of transforming growth factor beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	F		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2JV24 ensembl:ENSRNOP00000069322	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR003367 InterPro:IPR008859 InterPro:IPR028974	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008859	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028499	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028499	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003367 InterPro:IPR008859	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028499	F		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028499	P		Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028499	F		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:17879962^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	PMID:9304800^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:9304800^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043394	proteoglycan binding	PMID:9304800^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:9304800^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:9304800^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045652	regulation of megakaryocyte differentiation	Reactome:R-HSA-8936459	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-8936995 Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-6785565 Reactome:R-HSA-5173192 Reactome:R-HSA-5173005	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-2731112 Reactome:R-HSA-481007 Reactome:R-HSA-382054 Reactome:R-HSA-349603 Reactome:R-HSA-265429	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703 UniProtKB-SubCell:SL-0239	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Martin-Manso, G et al. (2012) Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis. PLoS ONE 7 e48775 PubMed GONUTS page
↑ ^2.0 ^2.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^3.0 ^3.1 Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
↑ ^4.0 ^4.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ Wang, JM et al. (2014) MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 34 99-109 PubMed GONUTS page
↑ ^8.0 ^8.1 Hamakawa, T et al. (2014) Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells. Prostate 74 590-601 PubMed GONUTS page
↑ ^9.0 ^9.1 Feng, N et al. (2015) miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1. Neurosci. Lett. 591 1-7 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Zampetaki, A et al. (2016) Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes. Diabetes 65 216-27 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ Jaffe, EA et al. (1983) Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix. Proc. Natl. Acad. Sci. U.S.A. 80 998-1002 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Martin-Manso, G et al. (2008) Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res. 68 7090-9 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Rege, TA et al. (2009) Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. J. Cell. Physiol. 218 94-103 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Mumby, SM et al. (1984) Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. J. Cell Biol. 98 646-52 PubMed GONUTS page
↑ ^21.0 ^21.1 Silverstein, RL et al. (1984) Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J. Clin. Invest. 74 1625-33 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Phillips, DR et al. (1980) Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets. J. Biol. Chem. 255 11629-32 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 Motegi, K et al. (2008) Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells. Exp. Cell Res. 314 2323-33 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Nunes, SS et al. (2008) Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1. J. Cell. Physiol. 214 828-37 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 Staniszewska, I et al. (2007) Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis. Circ. Res. 100 1308-16 PubMed GONUTS page
↑ ^26.0 ^26.1 Moralez, AM et al. (2005) Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions. J. Cell. Physiol. 203 328-34 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Krispin, A et al. (2006) Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states. Blood 108 3580-9 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 ^28.6 ^28.7 ^28.8 ^28.9 Adams, JC (1997) Thrombospondin-1. Int. J. Biochem. Cell Biol. 29 861-5 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Margosio, B et al. (2008) Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain. Int. J. Biochem. Cell Biol. 40 700-9 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Bale, MD et al. (1985) Incorporation of thrombospondin into fibrin clots. J. Biol. Chem. 260 7502-8 PubMed GONUTS page
↑ ^32.0 ^32.1 Lawler, JW et al. (1978) Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J. Biol. Chem. 253 8609-16 PubMed GONUTS page
↑ ^33.0 ^33.1 Yamauchi, M et al. (2007) Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle. Cancer Sci. 98 1491-7 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Isenberg, JS et al. (2007) Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J. Biol. Chem. 282 15404-15 PubMed GONUTS page
↑ Asch, AS et al. (1987) Isolation of the thrombospondin membrane receptor. J. Clin. Invest. 79 1054-61 PubMed GONUTS page
↑ Wolff, R et al. (1986) Interaction of thrombospondin with resting and stimulated human platelets. J. Biol. Chem. 261 6840-6 PubMed GONUTS page
↑ Bhattacharyya, S et al. (2008) Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose. J. Biol. Chem. 283 5699-707 PubMed GONUTS page
↑ ^38.0 ^38.1 Rico, MC et al. (2008) Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis. Transl Res 152 95-8 PubMed GONUTS page
↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Pallero, MA et al. (2008) Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J. 22 3968-79 PubMed GONUTS page
↑ Maloney, SL et al. (2009) Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane. Br. J. Cancer 101 957-66 PubMed GONUTS page
↑ Gayen Betal, S & Setty, BN (2008) Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain. Transl Res 152 165-77 PubMed GONUTS page
↑ ^43.0 ^43.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 ^44.4 Isenberg, JS et al. (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 102 13141-6 PubMed GONUTS page
↑ Qabar, AN et al. (1994) Thrombospondin 3 is a developmentally regulated heparin binding protein. J. Biol. Chem. 269 1262-9 PubMed GONUTS page

[PMID:23144964-1] 1.0 ^1.1 Martin-Manso, G et al. (2012) Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis. PLoS ONE 7 e48775 PubMed GONUTS page

[PMID:28327460-2] 2.0 ^2.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:23979707-3] 3.0 ^3.1 Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page

[PMID:28344315-4] 4.0 ^4.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:28124060-5] Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page

[PMID:20551380-6] 6.0 ^6.1 ^6.2 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:24177325-7] Wang, JM et al. (2014) MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 34 99-109 PubMed GONUTS page

[PMID:24615654-8] 8.0 ^8.1 Hamakawa, T et al. (2014) Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells. Prostate 74 590-601 PubMed GONUTS page

[PMID:25660232-9] 9.0 ^9.1 Feng, N et al. (2015) miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1. Neurosci. Lett. 591 1-7 PubMed GONUTS page

[PMID:27068509-10] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:26395742-11] Zampetaki, A et al. (2016) Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes. Diabetes 65 216-27 PubMed GONUTS page

[PMID:23533145-12] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:23658023-13] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:6341993-14] Jaffe, EA et al. (1983) Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix. Proc. Natl. Acad. Sci. U.S.A. 80 998-1002 PubMed GONUTS page

[PMID:19199708-15] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-16] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16502470-17] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:18757424-18] 18.0 ^18.1 ^18.2 ^18.3 Martin-Manso, G et al. (2008) Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res. 68 7090-9 PubMed GONUTS page

[PMID:18726995-19] 19.0 ^19.1 ^19.2 ^19.3 Rege, TA et al. (2009) Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. J. Cell. Physiol. 218 94-103 PubMed GONUTS page

[PMID:6693501-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Mumby, SM et al. (1984) Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. J. Cell Biol. 98 646-52 PubMed GONUTS page

[PMID:6438154-21] 21.0 ^21.1 Silverstein, RL et al. (1984) Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J. Clin. Invest. 74 1625-33 PubMed GONUTS page

[PMID:6777381-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Phillips, DR et al. (1980) Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets. J. Biol. Chem. 255 11629-32 PubMed GONUTS page

[PMID:18555217-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 Motegi, K et al. (2008) Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells. Exp. Cell Res. 314 2323-33 PubMed GONUTS page

[PMID:17879962-24] 24.0 ^24.1 ^24.2 Nunes, SS et al. (2008) Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1. J. Cell. Physiol. 214 828-37 PubMed GONUTS page

[PMID:17413041-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 Staniszewska, I et al. (2007) Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis. Circ. Res. 100 1308-16 PubMed GONUTS page

[PMID:15700281-26] 26.0 ^26.1 Moralez, AM et al. (2005) Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions. J. Cell. Physiol. 203 328-34 PubMed GONUTS page

[PMID:16882710-27] 27.0 ^27.1 ^27.2 ^27.3 Krispin, A et al. (2006) Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states. Blood 108 3580-9 PubMed GONUTS page

[PMID:9304800-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 ^28.6 ^28.7 ^28.8 ^28.9 Adams, JC (1997) Thrombospondin-1. Int. J. Biochem. Cell Biol. 29 861-5 PubMed GONUTS page

[PMID:17996481-29] 29.0 ^29.1 ^29.2 ^29.3 Margosio, B et al. (2008) Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain. Int. J. Biochem. Cell Biol. 40 700-9 PubMed GONUTS page

[PMID:22261194-30] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:3997886-31] 31.0 ^31.1 ^31.2 Bale, MD et al. (1985) Incorporation of thrombospondin into fibrin clots. J. Biol. Chem. 260 7502-8 PubMed GONUTS page

[PMID:101549-32] 32.0 ^32.1 Lawler, JW et al. (1978) Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J. Biol. Chem. 253 8609-16 PubMed GONUTS page

[PMID:17596205-33] 33.0 ^33.1 Yamauchi, M et al. (2007) Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle. Cancer Sci. 98 1491-7 PubMed GONUTS page

[PMID:17416590-34] 34.0 ^34.1 ^34.2 ^34.3 Isenberg, JS et al. (2007) Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J. Biol. Chem. 282 15404-15 PubMed GONUTS page

[PMID:2435757-35] Asch, AS et al. (1987) Isolation of the thrombospondin membrane receptor. J. Clin. Invest. 79 1054-61 PubMed GONUTS page

[PMID:3084490-36] Wolff, R et al. (1986) Interaction of thrombospondin with resting and stimulated human platelets. J. Biol. Chem. 261 6840-6 PubMed GONUTS page

[PMID:18096704-37] Bhattacharyya, S et al. (2008) Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose. J. Biol. Chem. 283 5699-707 PubMed GONUTS page

[PMID:18674744-38] 38.0 ^38.1 Rico, MC et al. (2008) Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis. Transl Res 152 95-8 PubMed GONUTS page

[PMID:21362503-39] Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page

[PMID:18653767-40] 40.0 ^40.1 ^40.2 Pallero, MA et al. (2008) Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J. 22 3968-79 PubMed GONUTS page

[PMID:19738618-41] Maloney, SL et al. (2009) Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane. Br. J. Cancer 101 957-66 PubMed GONUTS page

[PMID:18940719-42] Gayen Betal, S & Setty, BN (2008) Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain. Transl Res 152 165-77 PubMed GONUTS page

[PMID:21873635-43] 43.0 ^43.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16150726-44] 44.0 ^44.1 ^44.2 ^44.3 ^44.4 Isenberg, JS et al. (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 102 13141-6 PubMed GONUTS page

[PMID:8288588-45] Qabar, AN et al. (1994) Thrombospondin 3 is a developmentally regulated heparin binding protein. J. Biol. Chem. 269 1262-9 PubMed GONUTS page

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