HUMAN:IL15

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL15
Protein Name(s)	Interleukin-15 IL-15
External Links
UniProt	P40933
EMBL	U14407 X91233 X94223 X94222 AF031167 Y09908 AY720442 AK122993 AK290619 CR541980 CR542007 CH471056 CH471056 CH471056 CH471056 CH471056 BC018149 BC100961 BC100962 BC100963 Z38000
CCDS	CCDS3755.1 CCDS3756.1
RefSeq	NP_000576.1 NP_751915.1
UniGene	Hs.168132 Hs.602618
PDB	2XQB 2Z3Q 2Z3R 4GS7
PDBsum	2XQB 2Z3Q 2Z3R 4GS7
ProteinModelPortal	P40933
SMR	P40933
BioGrid	109813
DIP	DIP-3046N
IntAct	P40933
STRING	9606.ENSP00000296545
PhosphoSite	P40933
PRIDE	P40933
DNASU	3600
Ensembl	ENST00000296545 ENST00000320650 ENST00000394159 ENST00000477265 ENST00000514653 ENST00000529613
GeneID	3600
KEGG	hsa:3600
UCSC	uc003iis.3 uc010iol.3
CTD	3600
GeneCards	GC04P142557
HGNC	HGNC:5977
HPA	CAB004457 HPA037738
MIM	600554
neXtProt	NX_P40933
PharmGKB	PA29790
eggNOG	NOG44071
GeneTree	ENSGT00390000016264
HOVERGEN	HBG006142
InParanoid	P40933
KO	K05433
OMA	RSTSIQC
OrthoDB	EOG77Q4ZF
PhylomeDB	P40933
TreeFam	TF336199
SignaLink	P40933
ChiTaRS	IL15
EvolutionaryTrace	P40933
GeneWiki	Interleukin_15
GenomeRNAi	3600
NextBio	14065
PRO	PR:P40933
Proteomes	UP000005640
Bgee	P40933
CleanEx	HS_IL15
Genevestigator	P40933
GO	GO:0009986 GO:0005737 GO:0005768 GO:0005576 GO:0005615 GO:0005794 GO:0005887 GO:0016020 GO:0005634 GO:0007568 GO:0048469 GO:0007267 GO:0071305 GO:0045062 GO:0030212 GO:0006955 GO:0006954 GO:0048535 GO:0001779 GO:0048662 GO:0001866 GO:0008284 GO:0050778 GO:0050729 GO:0032740 GO:0032825 GO:0032819 GO:0042102 GO:0034105 GO:0042517 GO:0050691 GO:0045580 GO:0007165 GO:0014732
InterPro	IPR009079 IPR020439 IPR003443 IPR020466
Pfam	PF02372
PRINTS	PR01947 PR01930
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042506	tyrosine phosphorylation of Stat5 protein	PMID:12244150^[1]	ECO:0000314			P	Fig. 6 shows induction of tyrosine phosphorylation by IL-15.	complete CACAO 5774
involved_in	GO:0042119	neutrophil activation	PMID:15123770^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:15123770^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:27684068^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48346	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:15123770^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	PMID:15123770^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	PMID:24942581^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	PMID:24942581^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:12244150^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:16482511^[5]	ECO:0000305	curator inference used in manual assertion	GO:0032740	P	Seeded From UniProt	complete
involved_in	GO:0034105	positive regulation of tissue remodeling	PMID:16482511^[5]	ECO:0000305	curator inference used in manual assertion	GO:0032740	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	PMID:16482511^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:1904100	positive regulation of protein O-linked glycosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0050778	positive regulation of immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0050691	regulation of defense response to virus by host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0048535	lymph node development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0045580	regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0045062	extrathymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0032825	positive regulation of natural killer cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0032819	positive regulation of natural killer cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	F	Seeded From UniProt	complete
involved_in	GO:0001866	NK T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0001779	natural killer cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48346 ensembl:ENSMUSP00000034148	P	Seeded From UniProt	complete
involved_in	GO:0071305	cellular response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0030212	hyaluronan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97604 ensembl:ENSRNOP00000004590	C	Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003443	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003443 InterPro:IPR020466	C	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003443	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10851076^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:7759105^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8178155^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:8178155^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:10851076^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:10851076^[7] Reactome:R-HSA-8983335	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10851076^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10851076^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	Reactome:R-HSA-8983432	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8983384 Reactome:R-HSA-8983378 Reactome:R-HSA-8983374 Reactome:R-HSA-8983371 Reactome:R-HSA-8983335 Reactome:R-HSA-8983307 Reactome:R-HSA-8983300 Reactome:R-HSA-8983298 Reactome:R-HSA-449115	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Strengell, M et al. (2002) IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J. Immunol. 169 3600-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Ratthé, C & Girard, D (2004) Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. J. Leukoc. Biol. 76 162-8 PubMed GONUTS page
↑ Lacraz, G et al. () Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PLoS ONE 11 e0162995 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhen, A et al. (2014) CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J. Virol. 88 9934-46 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Carayol, G et al. (2000) Altered natural killer cell differentiation in CD34+ progenitors from chronic myeloid leukemia patients. Oncogene 19 2758-66 PubMed GONUTS page
↑ Anderson, DM et al. (1995) Chromosomal assignment and genomic structure of Il15. Genomics 25 701-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Grabstein, KH et al. (1994) Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264 965-8 PubMed GONUTS page

[PMID:12244150-1] 1.0 ^1.1 Strengell, M et al. (2002) IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J. Immunol. 169 3600-5 PubMed GONUTS page

[PMID:15123770-2] 2.0 ^2.1 ^2.2 ^2.3 Ratthé, C & Girard, D (2004) Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. J. Leukoc. Biol. 76 162-8 PubMed GONUTS page

[PMID:27684068-3] Lacraz, G et al. () Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PLoS ONE 11 e0162995 PubMed GONUTS page

[PMID:24942581-4] 4.0 ^4.1 Zhen, A et al. (2014) CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J. Virol. 88 9934-46 PubMed GONUTS page

[PMID:16482511-5] 5.0 ^5.1 ^5.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page

[PMID:14718574-6] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:10851076-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Carayol, G et al. (2000) Altered natural killer cell differentiation in CD34+ progenitors from chronic myeloid leukemia patients. Oncogene 19 2758-66 PubMed GONUTS page

[PMID:7759105-8] Anderson, DM et al. (1995) Chromosomal assignment and genomic structure of Il15. Genomics 25 701-6 PubMed GONUTS page

[PMID:8178155-9] 9.0 ^9.1 Grabstein, KH et al. (1994) Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264 965-8 PubMed GONUTS page

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HUMAN:IL15

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