GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:19322899
| Citation |
Liu, Z, Yang, L, Cui, Y, Wang, X, Guo, C, Huang, Z, Kan, Q, Liu, Z and Liu, Y (2009) Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. Inflamm. Bowel Dis. 15:1133-44 |
|---|---|
| Abstract |
Interleukin-21 (IL-21) is involved in T and NK cell activation and effector response and promotes Th17 cell differentiation. Here we investigated IL-21 receptor (IL-21R) expression in inflamed mucosa of inflammatory bowel disease (IBD) and evaluated its role in the induction of NK cell cytotoxicity and activation as well as Th17 differentiation. |
| Links |
PubMed Online version:10.1002/ibd.20923 |
| Keywords |
Adolescent; Adult; CD4-Positive T-Lymphocytes/metabolism; Cell Differentiation/physiology; Cytokines/metabolism; Cytotoxicity, Immunologic/physiology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Immunoenzyme Techniques; Inflammatory Bowel Diseases/immunology; Inflammatory Bowel Diseases/pathology; Interferon-gamma/metabolism; Interleukin-17/genetics; Interleukin-17/immunology; Interleukins/physiology; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Killer Cells, Natural/immunology; Lymphocyte Activation/immunology; Male; Middle Aged; Polymerase Chain Reaction; RNA, Messenger/genetics; RNA, Messenger/metabolism; Receptors, Interleukin-21/metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Helper-Inducer/pathology; Tumor Necrosis Factor-alpha/metabolism; Young Adult |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001819: positive regulation of cytokine production |
ECO:0000314: |
P |
Figure 3 |
complete | ||||
| GO:0005125: cytokine activity |
ECO:0000314: |
F |
Fig 3 shows that IL-21 enhances IBD NK-cell cytokine secretion |
complete | ||||
|
involved_in |
GO:0001819: positive regulation of cytokine production |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
