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HUMAN:IL21
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL21 | |
| Protein Name(s) | Interleukin-21
IL-21 Za11 | |
| External Links | ||
| UniProt | Q9HBE4 | |
| EMBL | AF254069 DQ645417 AY763518 AC053545 BC066258 BC066259 BC066260 BC066261 BC066262 BC069124 | |
| RefSeq | NP_001193935.1 NP_068575.1 | |
| UniGene | Hs.567559 | |
| PDB | 2OQP 3TGX | |
| PDBsum | 2OQP 3TGX | |
| ProteinModelPortal | Q9HBE4 | |
| SMR | Q9HBE4 | |
| BioGrid | 121857 | |
| IntAct | Q9HBE4 | |
| MINT | MINT-8201759 | |
| STRING | 9606.ENSP00000264497 | |
| DMDM | 55976599 | |
| PaxDb | Q9HBE4 | |
| PRIDE | Q9HBE4 | |
| DNASU | 59067 | |
| Ensembl | ENST00000264497 ENST00000611104 | |
| GeneID | 59067 | |
| KEGG | hsa:59067 | |
| UCSC | uc003ies.3 uc010int.4 | |
| CTD | 59067 | |
| GeneCards | GC04M123534 | |
| H-InvDB | HIX0031753 | |
| HGNC | HGNC:6005 | |
| MIM | 605384 615767 | |
| neXtProt | NX_Q9HBE4 | |
| Orphanet | 238569 | |
| PharmGKB | PA29820 | |
| eggNOG | NOG40525 | |
| GeneTree | ENSGT00390000010494 | |
| HOGENOM | HOG000113039 | |
| HOVERGEN | HBG052106 | |
| InParanoid | Q9HBE4 | |
| KO | K05434 | |
| OrthoDB | EOG7M98JN | |
| PhylomeDB | Q9HBE4 | |
| TreeFam | TF336380 | |
| SignaLink | Q9HBE4 | |
| EvolutionaryTrace | Q9HBE4 | |
| GeneWiki | Interleukin_21 | |
| GenomeRNAi | 59067 | |
| NextBio | 65134 | |
| PRO | PR:Q9HBE4 | |
| Proteomes | UP000005640 | |
| Bgee | Q9HBE4 | |
| CleanEx | HS_IL21 | |
| Genevestigator | Q9HBE4 | |
| GO | GO:0005615 GO:0005126 GO:0005134 GO:0048469 GO:0006955 GO:0030890 GO:0008284 GO:0050729 GO:0045078 GO:0032733 GO:0032740 GO:0002729 GO:0032825 GO:0045954 GO:0042102 GO:0034105 GO:0042511 GO:0042517 GO:0007165 | |
| InterPro | IPR009079 IPR003443 IPR028151 | |
| PANTHER | PTHR14356 | |
| Pfam | PF02372 | |
| SUPFAM | SSF47266 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005125 |
cytokine activity |
ECO:0000314 |
F |
Fig 3 shows that IL-21 enhances IBD NK-cell cytokine secretion |
complete | |||||
| GO:0001819 |
positive regulation of cytokine production |
ECO:0000314 |
P |
Figure 3 |
complete | |||||
| GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
ECO:0000314 |
P |
Fig. 5 shows that IL-21 enhances the cytotoxicity of Natural Killer cells. |
complete | |||||
| GO:0042503 |
tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Fig. 6 shows that IL-21 induces tyrosine phosphorylation of Stat3. |
complete | |||||
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 6 shows that when stimulated with IL21, STAT3 becomes more phosphorylated on tyrosine residues, but STAT5 does not. |
complete | |||||
| GO:0010537 |
positive regulation of activation of JAK1 kinase activity |
ECO:0000314 |
P |
Figure 7 shows stimulation with IL21 increases JAK1 tyrosine phosphorylation. |
complete | |||||
|
involved_in |
GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001819 |
positive regulation of cytokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032740 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034105 |
positive regulation of tissue remodeling |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032740 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032740 |
positive regulation of interleukin-17 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048469 |
cell maturation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045078 |
positive regulation of interferon-gamma biosynthetic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042102 |
positive regulation of T cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005134 |
interleukin-2 receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042102 |
positive regulation of T cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030890 |
positive regulation of B cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005126 |
cytokine receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005126 |
cytokine receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038114 |
interleukin-21-mediated signaling pathway |
Reactome:R-HSA-9020958 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-9006873 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Liu, Z et al. (2009) Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. Inflamm. Bowel Dis. 15 1133-44 PubMed GONUTS page
- ↑ 2.0 2.1 Skak, K et al. (2008) Interleukin-21 activates human natural killer cells and modulates their surface receptor expression. Immunology 123 575-83 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Strengell, M et al. (2002) IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J. Immunol. 169 3600-5 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page
- ↑ Sivori, S et al. (2003) IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Eur. J. Immunol. 33 3439-47 PubMed GONUTS page
- ↑ Monteleone, G et al. (2005) Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 128 687-94 PubMed GONUTS page
- ↑ Zhang, SQ et al. (2004) [Cloning and expression of human interleukin-21 cDNA in E.coli]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20 406-9 PubMed GONUTS page
- ↑ 8.0 8.1 Parrish-Novak, J et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408 57-63 PubMed GONUTS page
- ↑ Zhang, JL et al. (2003) Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Biochem. Biophys. Res. Commun. 300 291-6 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Rahman, M et al. (2007) Cloning and characterization of an isoform of interleukin-21. FEBS Lett. 581 4001-9 PubMed GONUTS page
- ↑ Mehta, DS et al. (2004) Biology of IL-21 and the IL-21 receptor. Immunol. Rev. 202 84-95 PubMed GONUTS page
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- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0032740 ! positive regulation of interleukin-17 production
- GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
- GO:0042517 ! positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0010537 ! positive regulation of activation of JAK1 kinase activity
- GO:0050729 ! positive regulation of inflammatory response
- GO:0034105 ! positive regulation of tissue remodeling
- GO:0030890 ! positive regulation of B cell proliferation
- GO:0045078 ! positive regulation of interferon-gamma biosynthetic process
- GO:0042102 ! positive regulation of T cell proliferation
- GO:0001819 ! positive regulation of cytokine production
- GO:0008284 ! positive regulation of cell population proliferation
- Primates
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