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Category:Team Shenanigans

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesORYSJ:PDI11Kelsi.Carlson, Team Shenanigans2012-11-18 16:07:51 CSTGO:0006508 proteolysis (P)PMID:22970232ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6: "results suggest that OsCP1 protease activity can be regulated by PDIL1-1."

challenge
acceptableORYSJ:PDI11Kelsi.Carlson, Team Shenanigans2012-11-18 15:59:42 CSTGO:0009960 endosperm development (P)PMID:22970232ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows that "PDIL1-1 may be involved in the development of the aleurone layer or outer part of the endosperm."

challenge
unacceptableMYCTU:H6S8V6Kelsi.Carlson, Team Shenanigans2012-11-18 14:26:27 CSTGO:0006916 anti-apoptosis (Figure 4 shows, "PE_PGRS11 induced rescue from oxidative stress: activation of antiapoptotic and inhibition of apoptotic signaling axis.")PMID:20558725IDA: Inferred from Direct Assay
challenge
acceptableRABIT:G1SY93Ashley.Carlisle, Team Shenanigans2012-11-16 22:21:21 CSTGO:0035556 intracellular signal transduction (P)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figures 1, 3, 4, 5, 8, & 9 show how Rac1 is part of the signal cascade.

challenge
acceptableRABIT:G1SY93Ashley.Carlisle, Team Shenanigans2012-11-16 22:19:15 CSTGO:0005886 plasma membrane (C)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figure 1

challenge
acceptableRABIT:G1SR27Ashley.Carlisle, Team Shenanigans2012-11-16 21:53:54 CSTGO:0035556 intracellular signal transduction (P)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figure 1, 3, 4, 5, 8, & 9 show how Grb2 is part of the signal cascade.

challenge
unacceptableRABIT:G1SZI2Ashley.Carlisle, Team Shenanigans2012-11-15 22:10:26 CSTGO:0035556 intracellular signal transduction (Figure 1, 3, 4, 5, 8, & 9 show how PAK1 is part of the signal cascade. )PMID:12885773IDA: Inferred from Direct Assay
challenge
acceptableRABIT:G1TRT1Ashley.Carlisle, Team Shenanigans2012-11-15 21:53:50 CSTGO:0035556 intracellular signal transduction (P)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figures 1, 3, 4, 5, 8, & 9 show how Sos1 is part of the signal cascade

challenge
acceptableRABIT:SNTA1Ashley.Carlisle, Team Shenanigans2012-11-15 18:03:53 CSTGO:0035556 intracellular signal transduction (P)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figure 1, 3, 4, 5, 8, & 9show how Syntrophin is part of the signal cascade.

challenge
acceptableRABIT:DAG1Ashley.Carlisle, Team Shenanigans2012-11-15 18:00:33 CSTGO:0035556 intracellular signal transduction (P)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figures 1, 3, 4, 5, 8, & 9 show how beta dystrophin is part of the signal cascade.

challenge
unacceptableMOUSE:PKD2Cece.Staley, Team Shenanigans2012-11-15 12:35:59 CSTGO:0004672 protein kinase activity (F)PMID:22233340ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows the 'role of PKD2 in thymus development of TCR transgenic mice.'

challenge
unacceptableMOUSE:PKD2Cece.Staley, Team Shenanigans2012-11-15 12:32:00 CSTGO:0004672 protein kinase activity (F)PMID:22233340ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows that 'PKD2 regulates thymic output.'

challenge
requireschangesMOUSE:PKD2Cece.Staley, Team Shenanigans2012-11-15 12:25:57 CSTGO:0004672 protein kinase activity (F)PMID:22311617ECO:0000269 experimental evidence used in manual assertion

Figure 3 shows 'in vitro migration and in vivo trafficking of WT and PKD2-deficient lymphocytes to secondary lymphoid tissues.'

challenge
unacceptableHUMAN:PKD1Cece.Staley, Team Shenanigans2012-11-15 12:06:15 CSTGO:0004672 protein kinase activity (F)PMID:23028574ECO:0000314 direct assay evidence used in manual assertion

Table 1 shows 'PKD1 selective inhibitors with little or no inhibitory activity for PKCα, PKCδ or CAMKIIα.'

challenge
unacceptableHUMAN:PKD1Cece.Staley, Team Shenanigans2012-11-15 12:02:09 CSTGO:0004672 protein kinase activity (F)PMID:23028574ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that '% residual PKD1 kinase activity calculated based on the total kinase activity measured in the absence of inhibitors (DMSO).'

challenge
acceptableHUMAN:TSP1Meghan.Flannery, Team Shenanigans2012-11-14 20:24:59 CSTGO:0006954 inflammatory response (P)PMID:23144964ECO:0000314 direct assay evidence used in manual assertion

Fig. 4 shows that TSP1 enhances the production of cytokines and chemokines by human IFN-γ-differentiated macrophages.

challenge
acceptableHUMAN:5NTDMeghan.Flannery, Team Shenanigans2012-11-14 11:25:50 CSTGO:0008253 5'-nucleotidase activity (F)PMID:7595232ECO:0000314 direct assay evidence used in manual assertion

Fig. 4 shows inhibition of ecto-5'-NT activity via different anti-

CD73 mAbs.

challenge
acceptableHUMAN:IL15Meghan.Flannery, Team Shenanigans2012-11-13 20:01:42 CSTGO:0042506 tyrosine phosphorylation of Stat5 protein (P)PMID:12244150ECO:0000314 direct assay evidence used in manual assertion

Fig. 6 shows induction of tyrosine phosphorylation by IL-15.

challenge
acceptableHUMAN:IL21Meghan.Flannery, Team Shenanigans2012-11-12 21:21:42 CSTGO:0042503 tyrosine phosphorylation of Stat3 protein (P)PMID:12244150ECO:0000314 direct assay evidence used in manual assertion

Fig. 6 shows that IL-21 induces tyrosine phosphorylation of Stat3.

challenge
acceptableHUMAN:IL21Meghan.Flannery, Team Shenanigans2012-11-12 20:27:43 CSTGO:0045954 positive regulation of natural killer cell mediated cytotoxicity (P)PMID:18005035ECO:0000314 direct assay evidence used in manual assertion

Fig. 5 shows that IL-21 enhances the cytotoxicity of Natural Killer cells.

challenge
requireschanges9VIRU:Q3HM11Ashley.Carlisle, Team Shenanigans2012-11-12 17:14:45 CSTGO:0071446 cellular response to salicylic acid stimulus (P)PMID:23071821ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows there is a reduction of SA-responsive gene transcripts after introduction of SA.

challenge
unacceptable9VIRU:Q3HM11Ashley.Carlisle, Team Shenanigans2012-11-12 17:08:46 CSTGO:0009753 response to jasmonic acid stimulus (P)PMID:23071821ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows there are higher levels of JA-responsive gene transcripts after JA is introduced.

challenge
requireschanges9VIRU:Q3HM11Ashley.Carlisle, Team Shenanigans2012-11-12 16:54:52 CSTGO:0010941 regulation of cell death (P)PMID:23071821ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows leaves not expressing the viral P6 protein have necrosis. So the viral P6 protein plays a role in regulation of cell death.

challenge
requireschangesHUMAN:VGFR2Cece.Staley, Team Shenanigans2012-11-12 16:24:18 CSTGO:0004716 receptor signaling protein tyrosine kinase activity (F)PMID:23139789ECO:0000314 direct assay evidence used in manual assertion

Figure one shows that 'HUVECs were subjected to geldanamycin (17-DMAG) treatment for indicated times, lysed and processed for immunoblotting (IB) to analyze indicated protein levels. Arrowhead indicates mature VEGFR2; TfR, transferrin receptor. (B) Quantification of mature VEGFR2 levels in control and geldanamycin-treated endothelial cells'

challenge
acceptable9VIRU:Q3HM11Ashley.Carlisle, Team Shenanigans2012-11-12 16:21:55 CSTGO:0043066 negative regulation of apoptotic process (P)PMID:23071821ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows leaves not expressing the viral P6 protein have necrosis.

challenge
acceptableHUMAN:5NTDMeghan.Flannery, Team Shenanigans2012-11-04 12:48:54 CSTGO:0007159 leukocyte cell-cell adhesion (P)PMID:7595232ECO:0000314 direct assay evidence used in manual assertion

Fig 5 clearly shows that CD73 is involved in lymphocyte binding to COS cells

challenge
acceptableMOUSE:LAMA1Ashley.Carlisle, Team Shenanigans2012-10-31 13:53:12 CDTGO:0006468 phosphorylation (P)PMID:12885773ECO:0000314 direct assay evidence used in manual assertion

Figure 9A.

challenge
requireschangesPIG:Q5DKW6Kelsi.Carlson, Team Shenanigans2012-10-21 11:45:25 CDTGO:0006091 generation of precursor metabolites and energy (P)PMID:22898868ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 shows that P2X7R is involved in energy metabolism.

challenge
requireschangesMOUSE:MBD5Cece.Staley, Team Shenanigans2012-10-19 22:32:36 CDTGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (P)PMID:23077600ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that 'The Mbd5-knockout mice had significantly smaller body size than their littermates, and the reduction in body weight was accompanied by a reduction in body length.'

challenge
requireschangesOLICO:Q51326Cece.Staley, Team Shenanigans2012-10-19 21:53:52 CDTGO:0008805 carbon-monoxide oxygenase activity (F)PMID:23077613ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows that 'Panel (A) compares the sequences of CoxD (295 aa) of O. carboxidovorans and BchI (350 aa) of R. capsulatus employing the UVa FASTA Server '

challenge
acceptableHUMAN:IL18Meghan.Flannery, Team Shenanigans2012-10-19 18:58:22 CDTGO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein (P)PMID:10903731ECO:0000314 direct assay evidence used in manual assertion

Fig 2 shows that stimulation of NK92 and NK92Ci cell lines with IL-18 results in activation and DNA binding of STAT3

challenge
acceptableHUMAN:ARBK1Kelsi.Carlson, Team Shenanigans2012-10-06 23:10:13 CDTGO:0019079 viral genome replication (P)PMID:23029581ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6 says "GRK2 plays a role in viral RNA synthesis."

challenge
acceptableHUMAN:ARBK1Kelsi.Carlson, Team Shenanigans2012-10-06 22:54:23 CDTGO:0046718 viral entry into host cell (P)PMID:23029581ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5 says "GRK2 plays a role in YFV-17D entry"

challenge
requireschangesMOUSE:ARBK1Kelsi.Carlson, Team Shenanigans2012-10-06 22:28:08 CDTGO:0022415 negative regulation of viral reproduction (P)PMID:23029581ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows that "GRK2 is required for YFV-17D propagation in mouse embryonic fibroblasts."

challenge
unacceptableHUMAN:DEDD2Meghan.Flannery, Team Shenanigans2012-10-05 12:59:23 CDTGO:0006915 apoptotic process (P)PMID:11741985ECO:0000316 genetic interaction evidence used in manual assertion

Fig 4 shows that DEDD2 is able to induce apoptosis

challenge
requireschangesHUMAN:IL21Meghan.Flannery, Team Shenanigans2012-10-03 21:26:20 CDTGO:0005125 cytokine activity (F)PMID:19322899ECO:0000314 direct assay evidence used in manual assertion

Fig 3 shows that IL-21 enhances IBD NK-cell cytokine secretion

challenge

Pages in category "Team Shenanigans"

The following 4 pages are in this category, out of 4 total.


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