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User:Katelin.Aisenbrey

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Spring 2013

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesHUMAN:ACTS2013-03-28 13:27:45 CDTGO:0030334 regulation of cell migration (P)PMID:23261211ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that human orbital fat stem cell migration is associated with F-actin reorganization.

challenge
unacceptableHUMAN:INS2013-04-11 12:06:21 CDTGO:0003985 acetyl-CoA C-acetyltransferase activity (F)PMID:23564383ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows that insulin stimulates ACAT1 activity and expression.

challenge

acceptable:0
unacceptable:1
requires_changes:1
flagged:0

Annotations challenged by Katelin.Aisenbrey

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history

0 annotations fixed by Katelin.Aisenbrey

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Fall 2012

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorHUMAN:DNLI12012-10-07 17:35:23 CDTGO:0003909 DNA ligase activity (F)PMID:15871698ECO:0000315 mutant phenotype evidence used in manual assertion

Data for DNA ligase activity in homo sapiens is shown in Figure 3.

challenge
acceptableOLICO:Q513262012-10-21 14:28:28 CDTGO:0016887 ATPase activity (F)PMID:23077613ECO:0000314 direct assay evidence used in manual assertion

Figure 5A shows that "CoxD displayed ATP-hydrolyzing activity."

challenge
unacceptableMOUSE:ALDOA2012-11-04 13:09:50 CSTGO:0004332 fructose-bisphosphate aldolase activity (F)PMID:23093405ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows the effect of aldolase activity depletion on proliferation of certain cell lines.

challenge
updatedbyinstructorHUMAN:PA2GA2012-11-04 15:37:16 CSTGO:0070374 positive regulation of ERK1 and ERK2 cascade (P)PMID:22837859ECO:0000314 direct assay evidence used in manual assertion

Figure 6 shows that Group V phospholipase A2 activity has an effect on human pulmonary endothelial cells' intracellular signaling.

challenge
acceptableHUMAN:PA2G52012-11-13 21:05:04 CSTGO:0070374 positive regulation of ERK1 and ERK2 cascade (P)PMID:22837859ECO:0000314 direct assay evidence used in manual assertion

Figure 6 shows that Group 5 phospholipase A2 (gVPLA2) "stimulates upregulation of multiple downstream signaling cascades," which includes the ERK 1 and 2 cascades.

challenge
acceptableHUMAN:PA2G52012-11-13 21:14:59 CSTGO:0010518 positive regulation of phospholipase activity (P)PMID:22837859ECO:0000314 direct assay evidence used in manual assertion

Figure 6 shows that activation of group 5 phospholipase A2 positively regulates phospholipase activity.

challenge
acceptableECOLI:BIRA2012-11-14 09:48:57 CSTGO:0009305 protein biotinylation (P)PMID:22412018ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that "BirA* promiscuously biotinylates endogenous proteins in mammalian cells."

challenge
unacceptableMOUSE:IL62012-11-14 10:13:15 CSTGO:0008518 reduced folate carrier activity (F)PMID:22546471ECO:0000314 direct assay evidence used in manual assertion

Interleukin-6 "reduced SLC19A1 [a reduced folate carrier] expression in mouse synoviocytes."

challenge

acceptable:4
unacceptable:2
requires_changes:0
flagged:0

Annotations challenged by Katelin.Aisenbrey

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history

0 annotations fixed by Katelin.Aisenbrey