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HUMAN:PA2G5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PLA2G5
Protein Name(s) Calcium-dependent phospholipase A2

Group V phospholipase A2 PLA2-10 Phosphatidylcholine 2-acylhydrolase 5

External Links
UniProt P39877
EMBL U03090
AY524778
AL158172
BC036792
CCDS CCDS202.1
PIR A49959
RefSeq NP_000920.1
XP_005245950.1
XP_005245952.1
XP_005245953.1
XP_006710755.1
XP_006710756.1
XP_006710757.1
XP_006710758.1
XP_006710759.1
UniGene Hs.319438
PDB 2GHN
PDBsum 2GHN
ProteinModelPortal P39877
SMR P39877
STRING 9606.ENSP00000364249
BindingDB P39877
ChEMBL CHEMBL4323
DMDM 730258
PaxDb P39877
PRIDE P39877
Ensembl ENST00000375108
GeneID 5322
KEGG hsa:5322
UCSC uc001bcx.3
CTD 5322
GeneCards GC01P020354
HGNC HGNC:9038
HPA HPA053361
MIM 228980
601192
neXtProt NX_P39877
Orphanet 363989
PharmGKB PA33366
eggNOG NOG330703
GeneTree ENSGT00760000119160
HOGENOM HOG000231749
HOVERGEN HBG008137
InParanoid P39877
KO K01047
OMA GTDWCCW
OrthoDB EOG7N63PF
PhylomeDB P39877
TreeFam TF319283
Reactome REACT_120722
REACT_120829
REACT_120906
REACT_121324
REACT_121369
REACT_121384
GeneWiki PLA2G5
GenomeRNAi 5322
NextBio 20590
PRO PR:P39877
Proteomes UP000005640
Bgee P39877
CleanEx HS_PLA2G5
Genevestigator P39877
GO GO:0009986
GO:0005576
GO:0005794
GO:0048471
GO:0005886
GO:0005509
GO:0047498
GO:0008201
GO:0050482
GO:0046474
GO:0019370
GO:0016042
GO:0006654
GO:0036151
GO:0036152
GO:0036148
GO:0036149
GO:0036150
GO:0006644
GO:0006663
GO:0051591
GO:0034097
GO:0044281
Gene3D 1.20.90.10
InterPro IPR001211
IPR013090
IPR016090
PANTHER PTHR11716
Pfam PF00068
PRINTS PR00389
SMART SM00085
SUPFAM SSF48619
PROSITE PS00119
PS00118

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:22837859[1]

ECO:0000314

P

Figure 6 shows that Group 5 phospholipase A2 (gVPLA2) "stimulates upregulation of multiple downstream signaling cascades," which includes the ERK 1 and 2 cascades.

complete
CACAO 5802

GO:0010518

positive regulation of phospholipase activity

PMID:22837859[1]

ECO:0000314

P

Figure 6 shows that activation of group 5 phospholipase A2 positively regulates phospholipase activity.

complete
CACAO 5806

involved_in

GO:0010518

positive regulation of phospholipase activity

PMID:22837859[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:22837859[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050482

arachidonic acid secretion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101899
PANTHER:PTN000197077
RGD:62051

P

Seeded From UniProt

complete

enables

GO:0047498

calcium-dependent phospholipase A2 activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000919171
RGD:3340
RGD:61949
RGD:62051
RGD:620857
UniProtKB:P04054

F

Seeded From UniProt

complete

involved_in

GO:0006644

phospholipid metabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101899
MGI:MGI:1349661
PANTHER:PTN000919171
RGD:61949
RGD:620857
UniProtKB:P14555

P

Seeded From UniProt

complete

enables

GO:0005543

phospholipid binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000919171
UniProtKB:P14555

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000919171
UniProtKB:P04054

F

Seeded From UniProt

complete

enables

GO:0004623

phospholipase A2 activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101842
MGI:MGI:101899
MGI:MGI:1349661
PANTHER:PTN000919171
RGD:61935
RGD:61949
UniProtKB:P00592
UniProtKB:P04054
UniProtKB:P14555

F

Seeded From UniProt

complete

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

P

Seeded From UniProt

complete

involved_in

GO:0050482

arachidonic acid secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

C

Seeded From UniProt

complete

enables

GO:0047498

calcium-dependent phospholipase A2 activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

F

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

P

Seeded From UniProt

complete

involved_in

GO:0019370

leukotriene biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

F

Seeded From UniProt

complete

involved_in

GO:0006663

platelet activating factor biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51433
ensembl:ENSRNOP00000022715

C

Seeded From UniProt

complete

enables

GO:0004623

phospholipase A2 activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001211
InterPro:IPR016090
InterPro:IPR036444

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001211

F

Seeded From UniProt

complete

involved_in

GO:0006644

phospholipid metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016090
InterPro:IPR036444

P

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001211

P

Seeded From UniProt

complete

involved_in

GO:0050482

arachidonic acid secretion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016090
InterPro:IPR036444

P

Seeded From UniProt

complete

enables

GO:0004623

phospholipase A2 activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.4

F

Seeded From UniProt

complete

enables

GO:0102568

phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.4

F

Seeded From UniProt

complete

enables

GO:0102567

phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.4

F

Seeded From UniProt

complete

enables

GO:0047498

calcium-dependent phospholipase A2 activity

PMID:8300559[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006644

phospholipid metabolic process

PMID:8300559[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:8300559[3]
Reactome:R-HSA-1602446
Reactome:R-HSA-1602417
Reactome:R-HSA-1602398
Reactome:R-HSA-1602377
Reactome:R-HSA-1602374
Reactome:R-HSA-1602368

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0036152

phosphatidylethanolamine acyl-chain remodeling

Reactome:R-HSA-1482839

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036151

phosphatidylcholine acyl-chain remodeling

Reactome:R-HSA-1482788

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036150

phosphatidylserine acyl-chain remodeling

Reactome:R-HSA-1482801

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036149

phosphatidylinositol acyl-chain remodeling

Reactome:R-HSA-1482922

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036148

phosphatidylglycerol acyl-chain remodeling

Reactome:R-HSA-1482925

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006654

phosphatidic acid biosynthetic process

Reactome:R-HSA-1483166

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0442

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Muñoz, NM et al. () Group V phospholipase A(2) increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane. Pulm Circ 2 182-92 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Chen, J et al. (1994) Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. J. Biol. Chem. 269 2365-8 PubMed GONUTS page
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