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GO:0070374positive regulation of ERK1 and ERK2 cascadePMID:22837859IDA: Inferred from Direct Assay P
This annotation made on page: HUMAN:PA2G5
By: Katelin.Aisenbrey (group Team Dihydrojasmone) on 2012-11-13 21:05:04 CST.

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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
Team Pterodactyl
2012-11-25 14:03:48 CST

The GO term is too specific. The evidence cited does not show that the rate of signal transduction is increased in an ERK cascade. No ERK cascade is even specified in the paper. Only the phosphorylation of ERK is observed in the assay. Phosphorylated ERK significantly increased in the presence of gVPLA2, according to Figure 6. A more appropriate GO term is "positive regulation of protein phosphorylation" (GO:0001934). The quote in the Notes section that gVPLA2 "stimulates upregulation of multiple downstream signaling cascades" refers to previous studies and is not representative of the experiments in the reference cited.

Bmcintosh2012-11-28 10:15:35 CSTYou need to be an instructor to view these notes.Acceptable