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HUMAN:ACTS
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ACTA1 (synonyms: ACTA) | |
| Protein Name(s) | Actin, alpha skeletal muscle
Alpha-actin-1 | |
| External Links | ||
| UniProt | P68133 | |
| EMBL | J00068 M20543 AF182035 CR536516 CR541796 AL160004 CH471098 BC012597 | |
| CCDS | CCDS1578.1 | |
| PIR | A31251 | |
| RefSeq | NP_001091.1 | |
| UniGene | Hs.1288 | |
| PDB | 1T44 | |
| PDBsum | 1T44 | |
| ProteinModelPortal | P68133 | |
| SMR | P68133 | |
| BioGrid | 106573 | |
| IntAct | P68133 | |
| MINT | MINT-135471 | |
| STRING | 9606.ENSP00000355645 | |
| PhosphoSite | P68133 | |
| DMDM | 61218043 | |
| MaxQB | P68133 | |
| PRIDE | P68133 | |
| DNASU | 58 | |
| Ensembl | ENST00000366684 | |
| GeneID | 58 | |
| KEGG | hsa:58 | |
| UCSC | uc001htm.3 | |
| CTD | 58 | |
| GeneCards | GC01M229567 | |
| GeneReviews | ACTA1 | |
| HGNC | HGNC:129 | |
| HPA | CAB000045 HPA041271 | |
| MIM | 102610 161800 255310 | |
| neXtProt | NX_P68133 | |
| Orphanet | 171439 2020 98904 171433 171430 171436 | |
| PharmGKB | PA24455 | |
| GeneTree | ENSGT00760000118957 | |
| HOGENOM | HOG000233340 | |
| HOVERGEN | HBG003771 | |
| InParanoid | P68133 | |
| KO | K10354 | |
| OMA | EDAKHYM | |
| OrthoDB | EOG72RMZ1 | |
| PhylomeDB | P68133 | |
| TreeFam | TF354237 | |
| Reactome | REACT_16969 | |
| SignaLink | P68133 | |
| ChiTaRS | ACTA1 | |
| EvolutionaryTrace | P68133 | |
| GeneWiki | Actin,_alpha_1 | |
| GenomeRNAi | 58 | |
| NextBio | 245 | |
| PRO | PR:P68133 | |
| Proteomes | UP000005640 | |
| Bgee | P68133 | |
| CleanEx | HS_ACTA1 | |
| Genevestigator | P68133 | |
| GO | GO:0015629 GO:0005884 GO:0072562 GO:0005829 GO:0005615 GO:0070062 GO:0030017 GO:0001725 GO:0005865 GO:0043531 GO:0005524 GO:0017022 GO:0005200 GO:0016049 GO:0006936 GO:0030049 GO:0009991 GO:0010226 GO:0009612 GO:0048545 GO:0043503 GO:0048741 GO:0030240 | |
| InterPro | IPR004000 IPR020902 IPR004001 | |
| PANTHER | PTHR11937 | |
| Pfam | PF00022 | |
| PRINTS | PR00190 | |
| SMART | SM00268 | |
| PROSITE | PS00406 PS00432 PS01132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016049 |
cell growth |
ECO:0000314 |
P |
Figure 3 shows severe growth deficiency in the absence of β-actin. |
complete | |||||
| GO:0030334 |
regulation of cell migration |
ECO:0000314 |
P |
Figure 2 shows that human orbital fat stem cell migration is associated with F-actin reorganization. |
complete | |||||
| GO:0005200 |
structural constituent of cytoskeleton |
ECO:0000304 |
F |
Autodiagram in figure 2 shows strains in food containing ActA are broader. |
complete | |||||
|
involved_in |
GO:0090131 |
mesenchyme migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:E1C3A6) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044297 |
cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0000134) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030175 |
filopodium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0000134) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0000134) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002367) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048741 |
skeletal muscle fiber development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030240 |
skeletal muscle thin filament assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030017 |
sarcomere |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005884 |
actin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005865 |
striated muscle thin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001725 |
stress fiber |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048741 |
skeletal muscle fiber development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68134 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071417 |
cellular response to organonitrogen compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048545 |
response to steroid hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043503 |
skeletal muscle fiber adaptation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010226 |
response to lithium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009991 |
response to extracellular stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009612 |
response to mechanical stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P68136 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043531 |
ADP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017022 |
myosin binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006936 |
muscle contraction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005200 |
structural constituent of cytoskeleton |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030049 |
muscle filament sliding |
Reactome:R-HSA-390522 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-390598 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bunnell, TM et al. (2011) β-Actin specifically controls cell growth, migration, and the G-actin pool. Mol. Biol. Cell 22 4047-58 PubMed GONUTS page
- ↑ Ong, WK et al. (2013) The activation of directional stem cell motility by green light-emitting diode irradiation. Biomaterials 34 1911-20 PubMed GONUTS page
- ↑ Jacquet, C et al. (2002) Expression of ActA, Ami, InlB, and listeriolysin O in Listeria monocytogenes of human and food origin. Appl. Environ. Microbiol. 68 616-22 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
- ↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
- ↑ Ilkovski, B et al. (2001) Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene. Am. J. Hum. Genet. 68 1333-43 PubMed GONUTS page
- ↑ van der Ven, PF et al. (1992) Differentiation of human skeletal muscle cells in culture: maturation as indicated by titin and desmin striation. Cell Tissue Res. 270 189-98 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Ilkovski, B et al. (2004) Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms. Hum. Mol. Genet. 13 1727-43 PubMed GONUTS page
- ↑ Anthony Akkari, P et al. (2003) Production of human skeletal alpha-actin proteins by the baculovirus expression system. Biochem. Biophys. Res. Commun. 307 74-9 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Nowak, KJ et al. (1999) Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy. Nat. Genet. 23 208-12 PubMed GONUTS page
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