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PMID:15871698
| Citation |
Smirnova, E, Toueille, M, Markkanen, E and Hübscher, U (2005) The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochem. J. 389:13-7 |
|---|---|
| Abstract |
The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA polymerase beta and Flap endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA. |
| Links |
PubMed PMC1184534 Online version:10.1042/BJ20050211 |
| Keywords |
Cell Cycle Proteins/metabolism; DNA Damage; DNA Ligases/metabolism; DNA Repair/physiology; Enzyme Activation; Exonucleases/metabolism; Humans; Multiprotein Complexes/metabolism; Proliferating Cell Nuclear Antigen/metabolism; Protein Binding; Schizosaccharomyces pombe Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003909: DNA ligase activity |
ECO:0000315: |
F |
Data for DNA ligase activity in homo sapiens is shown in Figure 3. |
complete | ||||
|
enables |
GO:0003909: DNA ligase activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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