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HUMAN:DNLI1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LIG1
Protein Name(s) DNA ligase 1

DNA ligase I Polydeoxyribonucleotide synthase [ATP] 1

External Links
UniProt P18858
EMBL M36067
AF527418
AK300370
AK314210
AC011466
KC877741
CH471177
BC108318
BC110622
CCDS CCDS12711.1
PIR A36048
RefSeq NP_000225.1
NP_001275992.1
NP_001275993.1
XP_006723279.1
UniGene Hs.1770
PDB 1X9N
PDBsum 1X9N
ProteinModelPortal P18858
SMR P18858
BioGrid 110166
DIP DIP-24215N
IntAct P18858
MINT MINT-141868
STRING 9606.ENSP00000263274
BindingDB P18858
ChEMBL CHEMBL5694
DrugBank DB00290
PhosphoSite P18858
DMDM 118773
MaxQB P18858
PaxDb P18858
PeptideAtlas P18858
PRIDE P18858
Ensembl ENST00000263274
ENST00000601091
ENST00000613670
GeneID 3978
KEGG hsa:3978
UCSC uc002pia.1
CTD 3978
GeneCards GC19M048618
HGNC HGNC:6598
HPA CAB037015
HPA041431
HPA048071
MIM 126391
neXtProt NX_P18858
PharmGKB PA30372
eggNOG COG1793
GeneTree ENSGT00750000117745
HOGENOM HOG000036006
HOVERGEN HBG005514
InParanoid P18858
KO K10747
OMA PQVVIEV
OrthoDB EOG7RFTGN
PhylomeDB P18858
TreeFam TF300342
Reactome REACT_1128
REACT_1385
REACT_1998
REACT_2192
REACT_228019
REACT_228145
REACT_74
REACT_8027
REACT_977
ChiTaRS LIG1
EvolutionaryTrace P18858
GeneWiki LIG1
GenomeRNAi 3978
NextBio 15592
PRO PR:P18858
Proteomes UP000005640
Bgee P18858
CleanEx HS_LIG1
ExpressionAtlas P18858
Genevestigator P18858
GO GO:0005694
GO:0005794
GO:0043231
GO:0005739
GO:0005654
GO:0005634
GO:0005524
GO:0003677
GO:0003910
GO:0003909
GO:0046872
GO:0009653
GO:0006284
GO:0051301
GO:0071897
GO:0051103
GO:0006259
GO:0006281
GO:0006271
GO:0006302
GO:0000724
GO:0006303
GO:0006273
GO:0000278
GO:0006289
GO:0006297
GO:0042542
GO:0000723
GO:0000722
GO:0032201
GO:0006283
Gene3D 1.10.3260.10
2.40.50.140
InterPro IPR000977
IPR012309
IPR012310
IPR016059
IPR012308
IPR012340
Pfam PF04679
PF01068
PF04675
SUPFAM SSF117018
SSF50249
TIGRFAMs TIGR00574
PROSITE PS00697
PS00333
PS50160

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003909

DNA ligase activity

PMID:15871698[1]

ECO:0000315

F

Data for DNA ligase activity in homo sapiens is shown in Figure 3.

complete
CACAO 5277

enables

GO:0003909

DNA ligase activity

PMID:15871698[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

PMID:19589734[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0033151

V(D)J recombination

PMID:9809069[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003909

DNA ligase activity

PMID:9809069[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1903461

Okazaki fragment processing involved in mitotic DNA replication

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000048794
PomBase:SPAC20G8.01

P

Seeded From UniProt

complete

involved_in

GO:0006273

lagging strand elongation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000048695
SGD:S000002323

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000048763
PomBase:SPAC20G8.01
SGD:S000002323
TAIR:locus:2199953
UniProtKB:P49916

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262619
PANTHER:PTN000048695

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101789
PANTHER:PTN000048763
PomBase:SPAC20G8.01
RGD:1309875
RGD:621424
SGD:S000002323
TAIR:locus:2199953
UniProtKB:P49916

C

Seeded From UniProt

complete

enables

GO:0003910

DNA ligase (ATP) activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262619
PANTHER:PTN000048695
PomBase:SPAC20G8.01
SGD:S000002323
UniProtKB:P49916
UniProtKB:P9WNV5
UniProtKB:Q8IES4

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012308
InterPro:IPR036599

F

Seeded From UniProt

complete

enables

GO:0003909

DNA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016059

F

Seeded From UniProt

complete

enables

GO:0003910

DNA ligase (ATP) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000977
InterPro:IPR012308
InterPro:IPR012309
InterPro:IPR012310
InterPro:IPR036599

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000977
InterPro:IPR012310

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000977
InterPro:IPR012308
InterPro:IPR012309
InterPro:IPR012310
InterPro:IPR036599

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000977
InterPro:IPR012308
InterPro:IPR012309
InterPro:IPR012310
InterPro:IPR036599

P

Seeded From UniProt

complete

involved_in

GO:0051103

DNA ligation involved in DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016059

P

Seeded From UniProt

complete

involved_in

GO:0071897

DNA biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000977

P

Seeded From UniProt

complete

enables

GO:0003910

DNA ligase (ATP) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.5.1.1

F

Seeded From UniProt

complete

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:8696349[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:8696349[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8696349[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:8696349[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

Reactome:R-HSA-5358606
Reactome:R-HSA-5358565

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006297

nucleotide-excision repair, DNA gap filling

Reactome:R-HSA-5696397

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006283

transcription-coupled nucleotide-excision repair

Reactome:R-HSA-6781827

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006266

DNA ligation

Reactome:R-HSA-174456

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-69173
Reactome:R-HSA-6782227
Reactome:R-HSA-5690997
Reactome:R-HSA-5651809
Reactome:R-HSA-5651805
Reactome:R-HSA-5651792
Reactome:R-HSA-5651789
Reactome:R-HSA-5651773
Reactome:R-HSA-5358592
Reactome:R-HSA-174456
Reactome:R-HSA-110371

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

enables

GO:0003909

DNA ligase activity

Reactome:R-HSA-69173
Reactome:R-HSA-5651805
Reactome:R-HSA-5651789
Reactome:R-HSA-5358592
Reactome:R-HSA-174456

ECO:0000304

author statement supported by traceable reference used in manual assertion





F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Smirnova, E et al. (2005) The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochem. J. 389 13-7 PubMed GONUTS page
  2. ↑ Chen, X et al. (2009) Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. DNA Repair (Amst.) 8 961-8 PubMed GONUTS page
  3. ↑ 3.0 3.1 Grawunder, U et al. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2 477-84 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Bentley, D et al. (1996) DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Nat. Genet. 13 489-91 PubMed GONUTS page
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