MOUSE:ALDOA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Aldoa (synonyms: Aldo1)
Protein Name(s)	Fructose-bisphosphate aldolase A Aldolase 1 Muscle-type aldolase
External Links
UniProt	P05064
EMBL	X03797 BC043026 BC050896 J05517 Y00516
CCDS	CCDS21845.1
PIR	S06323
RefSeq	NP_001170779.1 NP_031464.1 XP_006507273.1 XP_006507274.1
UniGene	Mm.275831
ProteinModelPortal	P05064
SMR	P05064
BioGrid	198067
IntAct	P05064
MINT	MINT-1581489
PhosphoSite	P05064
COMPLUYEAST-2DPAGE	P05064
REPRODUCTION-2DPAGE	IPI00221402 P05064
SWISS-2DPAGE	P05064
MaxQB	P05064
PaxDb	P05064
PRIDE	P05064
Ensembl	ENSMUST00000032934 ENSMUST00000106348
GeneID	11674
KEGG	mmu:11674
UCSC	uc009jsu.2
CTD	226
MGI	MGI:87994
eggNOG	COG3588
HOGENOM	HOG000220876
HOVERGEN	HBG002386
InParanoid	P05064
KO	K01623
OrthoDB	EOG744T94
PhylomeDB	P05064
Reactome	REACT_232322 REACT_263230
SABIO-RK	P05064
UniPathway	UPA00109
ChiTaRS	Aldoa
NextBio	279303
PRO	PR:P05064
Proteomes	UP000000589
Bgee	P05064
CleanEx	MM_ALDOA
ExpressionAtlas	P05064
Genevestigator	P05064
GO	GO:0031430 GO:0016020 GO:0043234 GO:0030018 GO:0004332 GO:0002020 GO:0006096 GO:0051289
Gene3D	3.20.20.70
InterPro	IPR029768 IPR013785 IPR029769 IPR000741
PANTHER	PTHR11627
Pfam	PF00274
PROSITE	PS00158

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004332	fructose-bisphosphate aldolase activity	PMID:23093405^[1]	ECO:0000314			F		Figure 2 shows the effect of aldolase activity depletion on proliferation of certain cell lines.	complete CACAO 5608
enables	GO:0004332	fructose-bisphosphate aldolase activity	PMID:23495010^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:23495010^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00883	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18676612^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:18676612^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0004057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18676612^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00883	P		Seeded From UniProt	complete
enables	GO:0004332	fructose-bisphosphate aldolase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00883	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:18676612^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16259	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	C		Seeded From UniProt	complete
enables	GO:0070061	fructose binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	F		Seeded From UniProt	complete
part_of	GO:0061827	sperm head	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061615	glycolytic process through fructose-6-phosphate	PMID:11785984^[6]	ECO:0000305	curator inference used in manual assertion	GO:0004332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	F		Seeded From UniProt	complete
part_of	GO:0035686	sperm fibrous sheath	PMID:17659271^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0035686	sperm fibrous sheath	PMID:16687649^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030388	fructose 1,6-bisphosphate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019242	methylglyoxal biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2089	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008360	regulation of cell shape	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007339	binding of sperm to zona pellucida	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006941	striated muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006754	ATP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006096	glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006000	fructose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18698006^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2089	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18698006^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2089	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2089	C		Seeded From UniProt	complete
enables	GO:0004332	fructose-bisphosphate aldolase activity	PMID:25637246^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87995	F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004332	fructose-bisphosphate aldolase activity	PMID:11785984^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:32716)	Seeded From UniProt	complete
enables	GO:0004332	fructose-bisphosphate aldolase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04075	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013785	F		Seeded From UniProt	complete
enables	GO:0004332	fructose-bisphosphate aldolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000741	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000741	P		Seeded From UniProt	complete
enables	GO:0004332	fructose-bisphosphate aldolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.1.2.13	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
part_of	GO:0031674	I band	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0478	C		Seeded From UniProt	complete
part_of	GO:0031430	M band	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0315	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ritterson Lew, C & Tolan, DR (2012) Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism. J. Biol. Chem. 287 42554-63 PubMed GONUTS page
↑ ^2.0 ^2.1 Ritterson Lew, C & Tolan, DR (2013) Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics. J. Cell. Biochem. 114 1928-39 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kramerova, I et al. (2008) Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum. Mol. Genet. 17 3271-80 PubMed GONUTS page
↑ ^6.0 ^6.1 Schliselfeld, LH & Danon, MJ (2002) Inverse relationship of skeletal muscle glycogen from wild-type and genetically modified mice to their phosphorylase a activity. Biochem. Biophys. Res. Commun. 290 874-7 PubMed GONUTS page
↑ Vemuganti, SA et al. (2007) Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition. Dev. Biol. 309 18-31 PubMed GONUTS page
↑ Krisfalusi, M et al. (2006) Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol. Reprod. 75 270-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Campanella, ME et al. (2008) Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. Blood 112 3900-6 PubMed GONUTS page
↑ Oppelt, SA et al. (2015) Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. Mol. Genet. Metab. 114 445-50 PubMed GONUTS page

[PMID:23093405-1] Ritterson Lew, C & Tolan, DR (2012) Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism. J. Biol. Chem. 287 42554-63 PubMed GONUTS page

[PMID:23495010-2] 2.0 ^2.1 Ritterson Lew, C & Tolan, DR (2013) Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics. J. Cell. Biochem. 114 1928-39 PubMed GONUTS page

[PMID:24006456-3] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:17634366-4] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:18676612-5] 5.0 ^5.1 ^5.2 ^5.3 Kramerova, I et al. (2008) Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum. Mol. Genet. 17 3271-80 PubMed GONUTS page

[PMID:11785984-6] 6.0 ^6.1 Schliselfeld, LH & Danon, MJ (2002) Inverse relationship of skeletal muscle glycogen from wild-type and genetically modified mice to their phosphorylase a activity. Biochem. Biophys. Res. Commun. 290 874-7 PubMed GONUTS page

[PMID:17659271-7] Vemuganti, SA et al. (2007) Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition. Dev. Biol. 309 18-31 PubMed GONUTS page

[PMID:16687649-8] Krisfalusi, M et al. (2006) Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol. Reprod. 75 270-8 PubMed GONUTS page

[PMID:18698006-9] 9.0 ^9.1 Campanella, ME et al. (2008) Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. Blood 112 3900-6 PubMed GONUTS page

[PMID:25637246-10] Oppelt, SA et al. (2015) Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. Mol. Genet. Metab. 114 445-50 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

MOUSE:ALDOA

Contents

Annotations

Notes

References

a

b

c

e

f

g

i

l

m

n

p

r

s

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools