PMID:11785984

Citation	Schliselfeld, LH and Danon, MJ (2002) Inverse relationship of skeletal muscle glycogen from wild-type and genetically modified mice to their phosphorylase a activity. Biochem. Biophys. Res. Commun. 290:874-7
Abstract	Leg muscle was biopsied and frozen for storage at -70 degrees C. from 5 wild-type mice, two knocked out acid alpha-glucosidase (GAA) gene mice, and seven glycogen synthase plus glucose muscle transporter transgenic mice. All of the wild-type mice had very little muscle glycogen (3.58 +/- 1.67 micromols glucosyl subunits per g muscle), and 52% or more of its glycogen phosphorylase activity without AMP (69% +/- 17% glycogen phosphorylase a). In contrast the GAA knockout and transgenic mice had glycogen ranging from 63 to 297 micromols glucosyl subunits per g muscle, and very little or no glycogen phosphorylase activity without 1.00 mM AMP (4.8% and less glycogen phosphorylase a). This suggests that there is an inverse relationship between mouse muscle phosphorylase a and the muscle's glycogen content.
Links	PubMed Online version:10.1006/bbrc.2001.6292
Keywords	Animals; Enzyme Activation/physiology; Fructose-Bisphosphate Aldolase/metabolism; Glucan 1,4-alpha-Glucosidase/deficiency; Glucan 1,4-alpha-Glucosidase/genetics; Glucan 1,4-alpha-Glucosidase/metabolism; Glucose Transporter Type 1; Glycogen/analysis; Glycogen/metabolism; Glycogen Debranching Enzyme System/metabolism; Glycogen Synthase/genetics; Glycogen Synthase/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Monosaccharide Transport Proteins/genetics; Monosaccharide Transport Proteins/metabolism; Muscle, Skeletal/chemistry; Muscle, Skeletal/metabolism; Phosphofructokinases/metabolism; Phosphorylase a/metabolism
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