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ECOLI:BIRA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) birA (ECO:0000255 with HAMAP-Rule:MF_00978) (synonyms: bioR, dhbB)
Protein Name(s) Bifunctional ligase/repressor BirA (ECO:0000255 with HAMAP-Rule:MF_00978)

Biotin operon repressor (ECO:0000255 with HAMAP-Rule:MF_00978) Biotin--[acetyl-CoA-carboxylase] ligase (ECO:0000255 with HAMAP-Rule:MF_00978) Biotin--protein ligase (ECO:0000255 with HAMAP-Rule:MF_00978) Biotin-[acetyl-CoA carboxylase] synthetase (ECO:0000255 with HAMAP-Rule:MF_00978)

External Links
UniProt P06709
EMBL M10123
M15820
L14557
U00006
U00096
AP009048
PIR B24029
RefSeq NP_418404.1
YP_491483.1
PDB 1BIA
1BIB
1HXD
1K67
2EWN
4WF2
PDBsum 1BIA
1BIB
1HXD
1K67
2EWN
4WF2
DisProt DP00349
ProteinModelPortal P06709
SMR P06709
DIP DIP-9224N
IntAct P06709
MINT MINT-1254106
STRING 511145.b3973
PaxDb P06709
EnsemblBacteria AAC76951
BAE77342
GeneID 12934397
948469
KEGG ecj:Y75_p3219
eco:b3973
PATRIC 32123467
EchoBASE EB0121
EcoGene EG10123
eggNOG COG0340
HOGENOM HOG000041812
InParanoid P06709
KO K03524
OMA IYSADIE
OrthoDB EOG6DNTBX
PhylomeDB P06709
BioCyc EcoCyc:BIOTINLIG-MONOMER
ECOL316407:JW3941-MONOMER
MetaCyc:BIOTINLIG-MONOMER
EvolutionaryTrace P06709
PRO PR:P06709
Proteomes UP000000318
UP000000625
Genevestigator P06709
GO GO:0005524
GO:0004077
GO:0003677
GO:0009102
GO:0009305
GO:0006355
GO:0006351
Gene3D 1.10.10.10
HAMAP MF_00978
InterPro IPR004408
IPR004409
IPR003142
IPR004143
IPR013196
IPR008988
IPR011991
PANTHER PTHR12835
Pfam PF02237
PF03099
PF08279
SUPFAM SSF50037
TIGRFAMs TIGR00121
TIGR00122
PROSITE PS51733

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009305

protein biotinylation

PMID:22412018[1]

ECO:0000314

P

Figure 2 shows that "BirA* promiscuously biotinylates endogenous proteins in mammalian cells."

complete
CACAO 5816

part_of

GO:0017053

transcriptional repressor complex

PMID:10497026[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006768

biotin metabolic process

PMID:10497026[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

PMID:10497026[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:10497026[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000984

bacterial-type RNA polymerase regulatory region sequence-specific DNA binding

PMID:10497026[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

PMID:1409631[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11124029[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000984

bacterial-type RNA polymerase regulatory region sequence-specific DNA binding

PMID:11124029[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0017053

transcriptional repressor complex

PMID:11124029[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:11124029[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

PMID:11124029[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006768

biotin metabolic process

PMID:11124029[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009305

protein biotinylation

PMID:22412018[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009102

biotin biosynthetic process

PMID:6456358[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004077

biotin-[acetyl-CoA-carboxylase] ligase activity

PMID:7024555[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:6456358[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004077

biotin-[acetyl-CoA-carboxylase] ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004408
InterPro:IPR030855

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004409
InterPro:IPR030855

P

Seeded From UniProt

complete

involved_in

GO:0006464

cellular protein modification process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003142
InterPro:IPR004143
InterPro:IPR004408

P

Seeded From UniProt

complete

enables

GO:0004077

biotin-[acetyl-CoA-carboxylase] ligase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.3.4.15

F

Seeded From UniProt

complete

enables

GO:0004077

biotin-[acetyl-CoA-carboxylase] ligase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000165595

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000165595

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000165595

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000165595

F

Seeded From UniProt

complete

involved_in

GO:0009305

protein biotinylation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000165595

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Roux, KJ et al. (2012) A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. J. Cell Biol. 196 801-10 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Streaker, ED & Beckett, D (1999) Ligand-linked structural changes in the Escherichia coli biotin repressor: the significance of surface loops for binding and allostery. J. Mol. Biol. 292 619-32 PubMed GONUTS page
  3. ↑ Wilson, KP et al. (1992) Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc. Natl. Acad. Sci. U.S.A. 89 9257-61 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Kwon, K et al. (2000) Multiple disordered loops function in corepressor-induced dimerization of the biotin repressor. J. Mol. Biol. 304 821-33 PubMed GONUTS page
  5. ↑ 5.0 5.1 Barker, DF & Campbell, AM (1981) Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli. J. Mol. Biol. 146 469-92 PubMed GONUTS page
  6. ↑ Barker, DF & Campbell, AM (1981) The birA gene of Escherichia coli encodes a biotin holoenzyme synthetase. J. Mol. Biol. 146 451-67 PubMed GONUTS page
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