User:Almond

CACAO II Spring 2012

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My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	HUMAN:PSN1	2011-10-03 20:17:38 CDT	GO:0060999 positive regulation of dendritic spine development (P)	PMID:21951279	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig 1. clearly shows the difference between WT and mutant cortical layer density.	challenge
unacceptable	HUMAN:IFNG	2011-10-05 16:26:50 CDT	GO:0008009 chemokine activity (F)	PMID:21962843	ECO:0000314 direct assay evidence used in manual assertion	Figure 2. demonstrates the different levels of the chemokines in the serum of humans with and without aortic aneurysms. It is shown that patients with thoracic aortic aneurysms have elevated levels of interferon gamma.	challenge
acceptable	I34A1:PB1F2	2011-10-06 12:37:43 CDT	GO:0035548 negative regulation of interferon-beta secretion (P)	PMID:2195805	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig 2 and 4. Protein PB1-F2 adversely affects IFN-β release.	challenge
acceptable	ERBV1:Q66776	2011-10-18 14:12:26 CDT	GO:0019028 viral capsid (C)	PMID:21930350	ECO:0000314 direct assay evidence used in manual assertion	The antigenic prominence of VP1 in ERBV was shown and the data suggest that the recombinant ERBV capsid proteins VP1 and VP2 present authentic viral epitopes. Figure 2, Figure 3	challenge
acceptable	MOUSE:NOS1	2011-10-18 20:10:17 CDT	GO:0050767 regulation of neurogenesis (P)	PMID:21960957	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows the differences in the rate of neurogenesis. According to the results, Nos1 expression is positively associated with adult neurogenesis and negatively with IMF volume.	challenge
acceptable	CVHSA:NS3B	2011-10-19 12:26:31 CDT	GO:0001817 regulation of cytokine production (P)	PMID:21561061	ECO:0000270 expression pattern evidence used in manual assertion	Protein 3b has been shown to trigger the ERK and JNK pathways which lead to an increase of AP-1 activity. AP-1 regulates transcription of cytokine MCP-1. Protein 3b is suggested to serve as a virulence factor for SARS-CoV. Figure 3, Figure 4, Figure 6.	challenge
acceptable	XENLA:TBX20	2011-11-15 19:44:51 CST	GO:0007507 heart development (P)	PMID:20460370	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 5, Figure 7 SMAD1 activation is required for the expression of Tbx20. Tbx20 serves as a direct transcriptional target of theBMP/SMAD1 signaling pathway and is essential for cardiac development.	challenge

acceptable:6
unacceptable:1
requires_changes:0
flagged:0