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CACAO II Spring 2012

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See the documentation at Special:CACAO for more information.

My Annotations

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableHUMAN:PSN12011-10-03 20:17:38 CDTGO:0060999 positive regulation of dendritic spine development (P)PMID:21951279ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 1. clearly shows the difference between WT and mutant cortical layer density.

unacceptableHUMAN:IFNG2011-10-05 16:26:50 CDTGO:0008009 chemokine activity (F)PMID:21962843ECO:0000314 direct assay evidence used in manual assertion

Figure 2. demonstrates the different levels of the chemokines in the serum of humans with and without aortic aneurysms. It is shown that patients with thoracic aortic aneurysms have elevated levels of interferon gamma.

acceptableI34A1:PB1F22011-10-06 12:37:43 CDTGO:0035548 negative regulation of interferon-beta secretion (P)PMID:2195805ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 2 and 4. Protein PB1-F2 adversely affects IFN-β release.

acceptableERBV1:Q667762011-10-18 14:12:26 CDTGO:0019028 viral capsid (C)PMID:21930350ECO:0000314 direct assay evidence used in manual assertion

The antigenic prominence of VP1 in ERBV was shown and the data suggest that the

recombinant ERBV capsid proteins VP1 and VP2 present authentic viral epitopes.

Figure 2, Figure 3

acceptableMOUSE:NOS12011-10-18 20:10:17 CDTGO:0050767 regulation of neurogenesis (P)PMID:21960957ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows the differences in the rate of neurogenesis.

According to the results, Nos1 expression is positively associated with adult neurogenesis and negatively with IMF volume.

acceptableCVHSA:NS3B2011-10-19 12:26:31 CDTGO:0001817 regulation of cytokine production (P)PMID:21561061ECO:0000270 expression pattern evidence used in manual assertion

Protein 3b has been shown to trigger the ERK and JNK pathways which lead to an increase of AP-1 activity. AP-1 regulates transcription of cytokine MCP-1. Protein 3b is suggested to serve as a virulence factor for SARS-CoV.

Figure 3, Figure 4, Figure 6.

acceptableXENLA:TBX202011-11-15 19:44:51 CSTGO:0007507 heart development (P)PMID:20460370ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5, Figure 7 SMAD1 activation is required for the expression of Tbx20. Tbx20 serves as a direct transcriptional target of theBMP/SMAD1 signaling pathway and is essential for cardiac development.