MOUSE:NOS1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nos1
Protein Name(s)	Nitric oxide synthase, brain Constitutive NOS NC-NOS NOS type I Neuronal NOS N-NOS nNOS Peptidyl-cysteine S-nitrosylase NOS1 bNOS
External Links
UniProt	Q9Z0J4
EMBL	D14552 S81982 AK141904
CCDS	CCDS19606.1
PIR	JN0609
RefSeq	NP_032738.1 XP_006530256.1
UniGene	Mm.442195 Mm.44249
PDB	2O60
PDBsum	2O60
ProteinModelPortal	Q9Z0J4
SMR	Q9Z0J4
BioGrid	201805
DIP	DIP-31556N
IntAct	Q9Z0J4
BindingDB	Q9Z0J4
ChEMBL	CHEMBL4719
PhosphoSite	Q9Z0J4
MaxQB	Q9Z0J4
PaxDb	Q9Z0J4
PRIDE	Q9Z0J4
DNASU	18125
Ensembl	ENSMUST00000142742 ENSMUST00000171055
GeneID	18125
KEGG	mmu:18125
UCSC	uc008zfy.2
CTD	4842
MGI	MGI:97360
eggNOG	COG4362
GeneTree	ENSGT00620000087711
HOGENOM	HOG000220884
HOVERGEN	HBG000159
InParanoid	Q9Z0J4
KO	K13240
OrthoDB	EOG79SDW7
PhylomeDB	Q9Z0J4
Reactome	REACT_198345 REACT_245499
EvolutionaryTrace	Q9Z0J4
NextBio	293344
PRO	PR:Q9Z0J4
Proteomes	UP000000589
Bgee	Q9Z0J4
CleanEx	MM_NOS1
ExpressionAtlas	Q9Z0J4
Genevestigator	Q9Z0J4
GO	GO:0005856 GO:0005829 GO:0043197 GO:0045121 GO:0005739 GO:0042383 GO:0045202 GO:0050660 GO:0010181 GO:0020037 GO:0005506 GO:0050661 GO:0003958 GO:0004517 GO:0071363 GO:0042738 GO:0045776 GO:0051926 GO:0051346 GO:0043267 GO:0051612 GO:0006809 GO:0007263 GO:0018119 GO:1901206 GO:0031284 GO:0035066 GO:0098735 GO:0045944 GO:0045893 GO:0045909 GO:0002028 GO:0006941
Gene3D	1.20.990.10 2.30.42.10 3.40.50.360 3.90.340.10
InterPro	IPR003097 IPR017927 IPR001094 IPR008254 IPR001709 IPR029039 IPR023173 IPR012144 IPR004030 IPR001433 IPR001478 IPR017938
Pfam	PF00667 PF00258 PF00175 PF02898 PF00595
PIRSF	PIRSF000333
PRINTS	PR00369 PR00371
SMART	SM00228
SUPFAM	SSF50156 SSF52218 SSF56512 SSF63380
PROSITE	PS51384 PS50902 PS60001 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050767	regulation of neurogenesis	PMID:21960957^[1]	ECO:0000314			P		Figure 2 shows the differences in the rate of neurogenesis. According to the results, Nos1 expression is positively associated with adult neurogenesis and negatively with IMF volume.	complete CACAO 2284
involved_in	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	PMID:21813683^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060076) occurs_in:(CL:0002609) regulates:(GO:0007268)	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:19800018^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19800018^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:19800018^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:19800018^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948) part_of:(GO:0016529)	Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	PMID:19800018^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948) part_of:(GO:0042383)	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	PMID:21960957^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0140196	positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	PMID:17242280^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098735	positive regulation of the force of heart contraction	PMID:17242280^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:11591728^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:11591728^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:16427017^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16427017^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:7545544^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:16427017^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:7545544^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:7545544^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:7545544^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051612	negative regulation of serotonin uptake	PMID:17452640^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099163	synaptic signaling by nitric oxide	PMID:19038221^[9]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099163	synaptic signaling by nitric oxide	PMID:19038221^[9]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:19038221^[9]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:19038221^[9]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 PANTHER:PTN000454042	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453988 RGD:3184	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 ZFIN:ZDB-GENE-040305-1	P		Seeded From UniProt	complete
involved_in	GO:0031284	positive regulation of guanylate cyclase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 UniProtKB:P29473 UniProtKB:P29474	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97744 PANTHER:PTN000453956 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000454042 RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002322100 RGD:3185	P		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 ZFIN:ZDB-GENE-001101-1	P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3186 UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453956 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228 UniProtKB:Q9SB48 UniProtKB:Q9UHB4	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453765 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011676 MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P29475 UniProtKB:P35228	F		Seeded From UniProt	complete
enables	GO:0003958	NADPH-hemoprotein reductase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453763 PomBase:SPBC29A10.01 RGD:68335 SGD:S000001084 TAIR:locus:2128951 UniProtKB:A0A1D8PLR7 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:P16435 UniProtKB:Q9UBK8	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902307	positive regulation of sodium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071872	cellular response to epinephrine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
enables	GO:0070402	NADPH binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061875	negative regulation of hepatic stellate cell contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051930	regulation of sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051926	negative regulation of calcium ion transport	PMID:12074580^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P	regulates_o_occurs_in:(EMAPA:32688) regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051346	negative regulation of hydrolase activity	PMID:12074580^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048148	behavioral response to cocaine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046676	negative regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12834919^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045822	negative regulation of heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045776	negative regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:10995443^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045184	establishment of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:10037495^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043434	response to peptide hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043267	negative regulation of potassium ion transport	PMID:12074580^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P	regulates_o_occurs_in:(EMAPA:32688) regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042738	exogenous drug catabolic process	PMID:11158245^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P		Seeded From UniProt	complete
part_of	GO:0042582	azurophil granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042311	vasodilation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034760	negative regulation of iron ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033555	multicellular organismal response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018119	peptidyl-cysteine S-nitrosylation	PMID:17293453^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008016	regulation of heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006941	striated muscle contraction	PMID:16537391^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006527	arginine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16537391^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29476	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29475	F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002028	regulation of sodium ion transport	PMID:12074580^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857227	P	regulates_o_occurs_in:(EMAPA:32688) regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	C		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	P		Seeded From UniProt	complete
involved_in	GO:0033555	multicellular organismal response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	C		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29475 ensembl:ENSP00000477999	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR008254 InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR017927 InterPro:IPR023173	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR004030 InterPro:IPR017927 InterPro:IPR023173 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.13.39	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Krebs, J et al. (2011) Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene. Front Neurosci 5 106 PubMed GONUTS page
↑ Dachtler, J et al. (2011) Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. J. Neurosci. 31 11220-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Beigi, F et al. () Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON. Nitric Oxide 21 226-33 PubMed GONUTS page
↑ ^4.0 ^4.1 Oceandy, D et al. (2007) Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 115 483-92 PubMed GONUTS page
↑ ^5.0 ^5.1 Schuh, K et al. (2001) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155 201-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Riccio, A et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21 283-94 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Brenman, JE et al. (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82 743-52 PubMed GONUTS page
↑ Chanrion, B et al. (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc. Natl. Acad. Sci. U.S.A. 104 8119-24 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Steinert, JR et al. (2008) Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse. Neuron 60 642-56 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Zhou, L et al. (2002) Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle. Biochem. Biophys. Res. Commun. 294 1030-5 PubMed GONUTS page
↑ Kim, MJ et al. (2003) Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice. Brain Res. 978 233-40 PubMed GONUTS page
↑ Adams, ME et al. (2000) Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J. Cell Biol. 150 1385-98 PubMed GONUTS page
↑ Keshet, GI et al. (1999) Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase. J. Neurochem. 72 1224-31 PubMed GONUTS page
↑ Imam, SZ et al. (2001) Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase. J. Neurochem. 76 745-9 PubMed GONUTS page
↑ Mustafa, AK et al. (2007) Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc. Natl. Acad. Sci. U.S.A. 104 2950-5 PubMed GONUTS page
↑ ^17.0 ^17.1 Steppan, J et al. (2006) Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 103 4759-64 PubMed GONUTS page

[PMID:21960957-1] 1.0 ^1.1 Krebs, J et al. (2011) Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene. Front Neurosci 5 106 PubMed GONUTS page

[PMID:21813683-2] Dachtler, J et al. (2011) Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. J. Neurosci. 31 11220-30 PubMed GONUTS page

[PMID:19800018-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Beigi, F et al. () Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON. Nitric Oxide 21 226-33 PubMed GONUTS page

[PMID:17242280-4] 4.0 ^4.1 Oceandy, D et al. (2007) Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 115 483-92 PubMed GONUTS page

[PMID:11591728-5] 5.0 ^5.1 Schuh, K et al. (2001) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155 201-5 PubMed GONUTS page

[PMID:16427017-6] 6.0 ^6.1 ^6.2 Riccio, A et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21 283-94 PubMed GONUTS page

[PMID:7545544-7] 7.0 ^7.1 ^7.2 ^7.3 Brenman, JE et al. (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82 743-52 PubMed GONUTS page

[PMID:17452640-8] Chanrion, B et al. (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc. Natl. Acad. Sci. U.S.A. 104 8119-24 PubMed GONUTS page

[PMID:19038221-9] 9.0 ^9.1 ^9.2 ^9.3 Steinert, JR et al. (2008) Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse. Neuron 60 642-56 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12074580-11] 11.0 ^11.1 ^11.2 ^11.3 Zhou, L et al. (2002) Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle. Biochem. Biophys. Res. Commun. 294 1030-5 PubMed GONUTS page

[PMID:12834919-12] Kim, MJ et al. (2003) Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice. Brain Res. 978 233-40 PubMed GONUTS page

[PMID:10995443-13] Adams, ME et al. (2000) Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J. Cell Biol. 150 1385-98 PubMed GONUTS page

[PMID:10037495-14] Keshet, GI et al. (1999) Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase. J. Neurochem. 72 1224-31 PubMed GONUTS page

[PMID:11158245-15] Imam, SZ et al. (2001) Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase. J. Neurochem. 76 745-9 PubMed GONUTS page

[PMID:17293453-16] Mustafa, AK et al. (2007) Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc. Natl. Acad. Sci. U.S.A. 104 2950-5 PubMed GONUTS page

[PMID:16537391-17] 17.0 ^17.1 Steppan, J et al. (2006) Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 103 4759-64 PubMed GONUTS page

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MOUSE:NOS1

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