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PMID:21930350
| Citation |
Horsington, JJ, Gilkerson, JR and Hartley, CA (2012) Mapping B-cell epitopes in equine rhinitis B viruses and identification of a neutralising site in the VP1 C-terminus. Vet. Microbiol. 155:128-36 |
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| Abstract |
Erbovirus is a genus of the family Picornaviridae and equine rhinitis B virus (ERBV) is the sole species. Erboviruses infect horses causing acute respiratory disease and sub-clinical and persistent infections. Despite the high seroprevalence and worldwide distribution of these viruses, the pathogenesis and antigenic structure of the three ERBV serotypes (ERBV1, 2 and 3) is poorly understood. To characterise linear epitopes on ERBV structural proteins, a set of fusion proteins were expressed in Escherichia coli. These proteins were tested in Western blot and ELISA and reactive proteins were also used to identify neutralisation epitopes. VP1 contained serotype specific epitopes whereas VP2 was highly cross-reactive across the serotypes. The C-terminus of VP1 accounted for most of the reactivity of full-length VP1 and was also the location of a neutralising site in each serotype. |
| Links |
PubMed Online version:10.1016/j.vetmic.2011.08.022 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0019028: viral capsid |
ECO:0000314: |
C |
The antigenic prominence of VP1 in ERBV was shown and the data suggest that the recombinant ERBV capsid proteins VP1 and VP2 present authentic viral epitopes. Figure 2, Figure 3 |
complete | ||||
|
part_of |
GO:0019028: viral capsid |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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