CVHSA:NS3B

Species (Taxon ID)	Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndromecoronavirus). (227859)
Gene Name(s)	No Information Provided.
Protein Name(s)	Non-structural protein 3b ns3b Accessory protein 3b Protein X2
External Links
UniProt	P59633
EMBL	AY278741 AY274119 AY282752 AY278554 AY278491 AY278487 AY278488 AY278489 AY278490 AY279354 AY291451 AY310120 AY291315 AY463059 AY338174 AY338175 AY348314 AP006557 AP006558 AP006559 AP006560 AP006561 AY323977 AY427439
RefSeq	NP_828853.1
GeneID	1489670
Proteomes	UP000000354
GO	GO:0033650 GO:0044196 GO:0006915 GO:0039526 GO:0039646 GO:0001817
InterPro	IPR022117
Pfam	PF12383

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001817	regulation of cytokine production	PMID:21561061	ECO:0000270			P		Protein 3b has been shown to trigger the ERK and JNK pathways which lead to an increase of AP-1 activity. AP-1 regulates transcription of cytokine MCP-1. Protein 3b is suggested to serve as a virulence factor for SARS-CoV. Figure 3, Figure 4, Figure 6.	complete CACAO 2304
involved_in	GO:0001817	regulation of cytokine production	PMID:21561061	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0033650	host cell mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1045 UniProtKB-SubCell:SL-0407	C		Seeded From UniProt	complete
involved_in	GO:0060153	modulation by virus of host cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1121	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048	C		Seeded From UniProt	complete
involved_in	GO:0039646	modulation by virus of host G0/G1 transition checkpoint	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1077	P		Seeded From UniProt	complete
involved_in	GO:0039526	modulation by virus of host apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1119	P		Seeded From UniProt	complete
part_of	GO:0044196	host cell nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0412	C		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.