MOUSE:PAX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pax2 (synonyms: Pax-2)
Protein Name(s)	Paired box protein Pax-2
External Links
UniProt	P32114
EMBL	X55781 BC148232 BC150484
PIR	A60086
RefSeq	NP_035167.4
UniGene	Mm.192158
ProteinModelPortal	P32114
SMR	P32114
BioGrid	202029
IntAct	P32114
iPTMnet	P32114
PhosphoSitePlus	P32114
MaxQB	P32114
PRIDE	P32114
GeneID	18504
KEGG	mmu:18504
UCSC	uc008hqa.2
CTD	5076
MGI	MGI:97486
HOGENOM	HOG000230938
HOVERGEN	HBG009115
InParanoid	P32114
KO	K15608
PhylomeDB	P32114
PRO	PR:P32114
Proteomes	UP000000589
CleanEx	MM_PAX2
GO	GO:0034451 GO:0005794 GO:0005815 GO:0005730 GO:0005634 GO:0043234 GO:0032993 GO:0005667 GO:0070742 GO:0003677 GO:0003700 GO:0000987 GO:0000978 GO:0016175 GO:0000982 GO:0008134 GO:0044212 GO:0048854 GO:0001658 GO:0043010 GO:0001709 GO:0071333 GO:0070301 GO:0071260 GO:0071300 GO:0007417 GO:0090102 GO:0090103 GO:0071542 GO:0010001 GO:0042472 GO:0001822 GO:0060231 GO:0003337 GO:0007501 GO:0072177 GO:0072164 GO:0072172 GO:0001823 GO:0072205 GO:0072221 GO:0072207 GO:0072162 GO:0072075 GO:0072289 GO:0001656 GO:0043066 GO:1900215 GO:1900218 GO:0043154 GO:0045918 GO:0072305 GO:1900212 GO:0043069 GO:2000378 GO:0000122 GO:0045892 GO:0072179 GO:0001843 GO:0061360 GO:0002072 GO:0021554 GO:0021631 GO:0021633 GO:0031016 GO:0061205 GO:0090190 GO:0050679 GO:0072108 GO:2000594 GO:0072300 GO:2000597 GO:0045944 GO:0045893 GO:0039003 GO:0048793 GO:0043491 GO:0072593 GO:0042981 GO:0072307 GO:0035566 GO:0043067 GO:0072001 GO:0003406 GO:0048863 GO:0006351 GO:0072189 GO:0035799 GO:0072197 GO:0001657 GO:0001655 GO:0021650
CDD	cd00131
Gene3D	1.10.10.10
InterPro	IPR009057 IPR001523 IPR022130 IPR036388
Pfam	PF00292 PF12403
PRINTS	PR00027
SMART	SM00351
SUPFAM	SSF46689
PROSITE	PS00034 PS51057

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11731455^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:14573)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:11731455^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:11731455^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
Colocalizes with	GO:0016581	NuRD complex	PMID:29370269^[2]	ECO:0000314			C		Figure 2C shows that PAX2 (Pax2 in paper) associates with the NuRD complex in mice.	complete CACAO 13077
involved_in	GO:0090103	cochlea morphogenesis	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090102	cochlea development	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061360	optic chiasma development	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021650	vestibulocochlear nerve formation	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021633	optic nerve structural organization	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021631	optic nerve morphogenesis	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021554	optic nerve development	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002072	optic cup morphogenesis involved in camera-type eye development	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	PMID:8951055^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000597	positive regulation of optic nerve formation	PMID:18083586^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000594	positive regulation of metanephric DCT cell differentiation	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
involved_in	GO:1900218	negative regulation of apoptotic process involved in metanephric nephron tubule development	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900215	negative regulation of apoptotic process involved in metanephric collecting duct development	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:17538188^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:17881463^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	PMID:20727173^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q00288	P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	PMID:17538188^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072305	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072300	positive regulation of metanephric glomerulus development	PMID:17047028^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072289	metanephric nephron tubule formation	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072221	metanephric distal convoluted tubule development	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072207	metanephric epithelium development	PMID:7856737^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	PMID:10980123^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072197	ureter morphogenesis	PMID:1723950^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072189	ureter development	PMID:17881463^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072179	nephric duct formation	PMID:12435636^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	PMID:14695376^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	PMID:1723950^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072172	mesonephric tubule formation	PMID:17300925^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	PMID:14695376^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	PMID:1723950^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072162	metanephric mesenchymal cell differentiation	PMID:16368682^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	PMID:12435636^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q00288	P		Seeded From UniProt	complete
involved_in	GO:0072075	metanephric mesenchyme development	PMID:20171952^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:17357786^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:17538188^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:20171952^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:17164400^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070742	C2H2 zinc finger domain binding	PMID:7720589^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:17538188^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061205	paramesonephric duct development	PMID:14695376^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:20171952^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:12435636^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
involved_in	GO:0045918	negative regulation of cytolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16319112^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q00288	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16735463^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17314325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17166926^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12435636^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16368682^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17047028^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17785448^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19037705^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17047028^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:17538188^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17785448^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17164400^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10980123^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:12435636^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	PMID:20727173^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q00288	P		Seeded From UniProt	complete
involved_in	GO:0039003	pronephric field specification	PMID:12435636^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035799	ureter maturation	PMID:17881463^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035566	regulation of metanephros size	PMID:17881463^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034451	centriolar satellite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:17785448^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:1723950^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007501	mesodermal cell fate specification	PMID:17785448^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:1723950^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15153556^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18607644^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	PMID:10322633^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	PMID:12435636^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001655	urogenital system development	PMID:12435636^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q00288	P		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:17785448^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:16916509^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	has_participant:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072197	ureter morphogenesis	PMID:21731775^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95388 MGI:MGI:95457 MGI:MGI:95663 MGI:MGI:99783	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060231	mesenchymal to epithelial transition	PMID:8575306^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	occurs_in:(EMAPA:17373)\|occurs_in:(EMAPA:16747)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12200151^[32]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1343102)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045918	negative regulation of cytolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043069	negative regulation of programmed cell death	PMID:16672320^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857114	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043067	regulation of programmed cell death	PMID:16672320^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88138	P	regulates_o_occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12756174^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:16916509^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109344	P	has_participant:(EMAPA:16194)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15242798^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	has_participant:(EMAPA:17593)\|has_participant:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035566	regulation of metanephros size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	P		Seeded From UniProt	complete
part_of	GO:0034451	centriolar satellite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305568	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	F		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305568	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10536059^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16525)\|part_of:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305568	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12756174^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001823	mesonephros development	PMID:8575306^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	results_in_development_of:(EMAPA:16747)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:16672320^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88138	P	results_in_development_of:(EMAPA:35592)\|results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:16672320^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857114	P	results_in_development_of:(EMAPA:35592)\|results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:12756174^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	occurs_in:(EMAPA:16674) results_in_determination_of:(CL:0000529)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:16672320^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:16672320^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857114	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001657	ureteric bud development	PMID:16018995^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:109344	P	results_in_development_of:(EMAPA:17376)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:12435636^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97492	P	results_in_development_of:(EMAPA:16579)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:8575306^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001655	urogenital system development	PMID:8575306^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857673	P	results_in_development_of:(EMAPA:28425)\|results_in_development_of:(EMAPA:27665)	Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02962	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15905411^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1277163 MGI:MGI:1346018	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001523 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001523	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:8413205^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:8413205^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:16243425^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:10197584^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10197584^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Brophy, PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128 4747-56 PubMed GONUTS page
↑ Patel, D et al. (2018) The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS ONE 13 e0191689 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Torres, M et al. (1996) Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122 3381-91 PubMed GONUTS page
↑ Alur, RP et al. (2008) Optic nerve axon number in mouse is regulated by PAX2. J AAPOS 12 117-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Narlis, M et al. (2007) Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J. Am. Soc. Nephrol. 18 1121-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Zhang, SL et al. (2007) Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis. J. Am. Soc. Nephrol. 18 2105-15 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Murawski, IJ et al. (2007) Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse. Am. J. Physiol. Renal Physiol. 293 F1736-45 PubMed GONUTS page
↑ ^8.0 ^8.1 Bouchard, M et al. (2010) Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev. Biol. 10 89 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Clarke, JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum. Mol. Genet. 15 3420-8 PubMed GONUTS page
↑ Eccles, MR et al. (1995) Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am. J. Pathol. 146 40-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Torban, E et al. (2000) PAX2 suppresses apoptosis in renal collecting duct cells. Am. J. Pathol. 157 833-42 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Plachov, D et al. (1990) Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110 643-51 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Bouchard, M et al. (2002) Nephric lineage specification by Pax2 and Pax8. Genes Dev. 16 2958-70 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Kobayashi, A et al. (2004) Requirement of Lim1 for female reproductive tract development. Development 131 539-49 PubMed GONUTS page
↑ Kobayashi, H et al. (2007) Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech. Dev. 124 290-303 PubMed GONUTS page
↑ ^16.0 ^16.1 Torban, E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J. Biol. Chem. 281 12705-12 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Mae, S et al. (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem. Biophys. Res. Commun. 393 877-82 PubMed GONUTS page
↑ Zhang, SL et al. (2007) Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop. Pediatr. Nephrol. 22 813-24 PubMed GONUTS page
↑ ^19.0 ^19.1 Cohen, T et al. (2007) PAX2 is reactivated in urinary tract obstruction and partially protects collecting duct cells from programmed cell death. Am. J. Physiol. Renal Physiol. 292 F1267-73 PubMed GONUTS page
↑ Ryan, G et al. (1995) Repression of Pax-2 by WT1 during normal kidney development. Development 121 867-75 PubMed GONUTS page
↑ Grote, D et al. (2006) Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133 53-61 PubMed GONUTS page
↑ Dziarmaga, A et al. (2006) Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. Am. J. Physiol. Renal Physiol. 291 F913-20 PubMed GONUTS page
↑ Pillai, A et al. (2007) Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development 134 357-66 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Gong, KQ et al. (2007) A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol. Cell. Biol. 27 7661-8 PubMed GONUTS page
↑ Nakane, A et al. () Pax2 overexpression in embryoid bodies induces upregulation of integrin alpha8 and aquaporin-1. In Vitro Cell. Dev. Biol. Anim. 45 62-8 PubMed GONUTS page
↑ Zhang, SL et al. (2004) Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J. Am. Soc. Nephrol. 15 1452-65 PubMed GONUTS page
↑ Chen, YW et al. (2008) Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr. Nephrol. 23 1769-77 PubMed GONUTS page
↑ Donovan, MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev. Genet. 24 252-62 PubMed GONUTS page
↑ ^29.0 ^29.1 Zou, D et al. (2006) Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev. Biol. 298 430-41 PubMed GONUTS page
↑ Boualia, SK et al. (2011) Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2. PLoS ONE 6 e21529 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 Torres, M et al. (1995) Pax-2 controls multiple steps of urogenital development. Development 121 4057-65 PubMed GONUTS page
↑ Yuan, SS et al. (2002) Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. Biochem. Biophys. Res. Commun. 296 1019-25 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 Dziarmaga, A et al. (2006) Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J. Am. Soc. Nephrol. 17 1568-75 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Bäumer, N et al. (2003) Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130 2903-15 PubMed GONUTS page
↑ Burton, Q et al. (2004) The role of Pax2 in mouse inner ear development. Dev. Biol. 272 161-75 PubMed GONUTS page
↑ Hao, Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev. Dyn. 216 201-17 PubMed GONUTS page
↑ Sajithlal, G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev. Biol. 284 323-36 PubMed GONUTS page
↑ Mui, SH et al. (2005) Vax genes ventralize the embryonic eye. Genes Dev. 19 1249-59 PubMed GONUTS page
↑ ^39.0 ^39.1 Kozmik, Z et al. (1993) Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol. Cell. Biol. 13 6024-35 PubMed GONUTS page
↑ Jankovic, J et al. () The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77 128-38 PubMed GONUTS page
↑ ^41.0 ^41.1 Mansouri, A et al. (1999) Pax genes and their role in organogenesis. Cancer Res. 59 1707s-1709s; discussion 1709s-1710s PubMed GONUTS page

[PMID:11731455-1] 1.0 ^1.1 ^1.2 Brophy, PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128 4747-56 PubMed GONUTS page

[PMID:29370269-2] Patel, D et al. (2018) The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS ONE 13 e0191689 PubMed GONUTS page

[PMID:8951055-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Torres, M et al. (1996) Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122 3381-91 PubMed GONUTS page

[PMID:18083586-4] Alur, RP et al. (2008) Optic nerve axon number in mouse is regulated by PAX2. J AAPOS 12 117-21 PubMed GONUTS page

[PMID:17314325-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Narlis, M et al. (2007) Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J. Am. Soc. Nephrol. 18 1121-9 PubMed GONUTS page

[PMID:17538188-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Zhang, SL et al. (2007) Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis. J. Am. Soc. Nephrol. 18 2105-15 PubMed GONUTS page

[PMID:17881463-7] 7.0 ^7.1 ^7.2 ^7.3 Murawski, IJ et al. (2007) Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse. Am. J. Physiol. Renal Physiol. 293 F1736-45 PubMed GONUTS page

[PMID:20727173-8] 8.0 ^8.1 Bouchard, M et al. (2010) Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev. Biol. 10 89 PubMed GONUTS page

[PMID:17047028-9] 9.0 ^9.1 ^9.2 Clarke, JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum. Mol. Genet. 15 3420-8 PubMed GONUTS page

[PMID:7856737-10] Eccles, MR et al. (1995) Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am. J. Pathol. 146 40-5 PubMed GONUTS page

[PMID:10980123-11] 11.0 ^11.1 Torban, E et al. (2000) PAX2 suppresses apoptosis in renal collecting duct cells. Am. J. Pathol. 157 833-42 PubMed GONUTS page

[PMID:1723950-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Plachov, D et al. (1990) Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110 643-51 PubMed GONUTS page

[PMID:12435636-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Bouchard, M et al. (2002) Nephric lineage specification by Pax2 and Pax8. Genes Dev. 16 2958-70 PubMed GONUTS page

[PMID:14695376-14] 14.0 ^14.1 ^14.2 Kobayashi, A et al. (2004) Requirement of Lim1 for female reproductive tract development. Development 131 539-49 PubMed GONUTS page

[PMID:17300925-15] Kobayashi, H et al. (2007) Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech. Dev. 124 290-303 PubMed GONUTS page

[PMID:16368682-16] 16.0 ^16.1 Torban, E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J. Biol. Chem. 281 12705-12 PubMed GONUTS page

[PMID:20171952-17] 17.0 ^17.1 ^17.2 Mae, S et al. (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem. Biophys. Res. Commun. 393 877-82 PubMed GONUTS page

[PMID:17357786-18] Zhang, SL et al. (2007) Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop. Pediatr. Nephrol. 22 813-24 PubMed GONUTS page

[PMID:17164400-19] 19.0 ^19.1 Cohen, T et al. (2007) PAX2 is reactivated in urinary tract obstruction and partially protects collecting duct cells from programmed cell death. Am. J. Physiol. Renal Physiol. 292 F1267-73 PubMed GONUTS page

[PMID:7720589-20] Ryan, G et al. (1995) Repression of Pax-2 by WT1 during normal kidney development. Development 121 867-75 PubMed GONUTS page

[PMID:16319112-21] Grote, D et al. (2006) Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133 53-61 PubMed GONUTS page

[PMID:16735463-22] Dziarmaga, A et al. (2006) Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. Am. J. Physiol. Renal Physiol. 291 F913-20 PubMed GONUTS page

[PMID:17166926-23] Pillai, A et al. (2007) Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development 134 357-66 PubMed GONUTS page

[PMID:17785448-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Gong, KQ et al. (2007) A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol. Cell. Biol. 27 7661-8 PubMed GONUTS page

[PMID:19037705-25] Nakane, A et al. () Pax2 overexpression in embryoid bodies induces upregulation of integrin alpha8 and aquaporin-1. In Vitro Cell. Dev. Biol. Anim. 45 62-8 PubMed GONUTS page

[PMID:15153556-26] Zhang, SL et al. (2004) Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J. Am. Soc. Nephrol. 15 1452-65 PubMed GONUTS page

[PMID:18607644-27] Chen, YW et al. (2008) Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr. Nephrol. 23 1769-77 PubMed GONUTS page

[PMID:10322633-28] Donovan, MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev. Genet. 24 252-62 PubMed GONUTS page

[PMID:16916509-29] 29.0 ^29.1 Zou, D et al. (2006) Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev. Biol. 298 430-41 PubMed GONUTS page

[PMID:21731775-30] Boualia, SK et al. (2011) Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2. PLoS ONE 6 e21529 PubMed GONUTS page

[PMID:8575306-31] 31.0 ^31.1 ^31.2 ^31.3 Torres, M et al. (1995) Pax-2 controls multiple steps of urogenital development. Development 121 4057-65 PubMed GONUTS page

[PMID:12200151-32] Yuan, SS et al. (2002) Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. Biochem. Biophys. Res. Commun. 296 1019-25 PubMed GONUTS page

[PMID:16672320-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 Dziarmaga, A et al. (2006) Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J. Am. Soc. Nephrol. 17 1568-75 PubMed GONUTS page

[PMID:12756174-34] 34.0 ^34.1 ^34.2 Bäumer, N et al. (2003) Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130 2903-15 PubMed GONUTS page

[PMID:15242798-35] Burton, Q et al. (2004) The role of Pax2 in mouse inner ear development. Dev. Biol. 272 161-75 PubMed GONUTS page

[PMID:10536059-36] Hao, Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev. Dyn. 216 201-17 PubMed GONUTS page

[PMID:16018995-37] Sajithlal, G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev. Biol. 284 323-36 PubMed GONUTS page

[PMID:15905411-38] Mui, SH et al. (2005) Vax genes ventralize the embryonic eye. Genes Dev. 19 1249-59 PubMed GONUTS page

[PMID:8413205-39] 39.0 ^39.1 Kozmik, Z et al. (1993) Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol. Cell. Biol. 13 6024-35 PubMed GONUTS page

[PMID:16243425-40] Jankovic, J et al. () The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77 128-38 PubMed GONUTS page

[PMID:10197584-41] 41.0 ^41.1 Mansouri, A et al. (1999) Pax genes and their role in organogenesis. Cancer Res. 59 1707s-1709s; discussion 1709s-1710s PubMed GONUTS page

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