MOUSE:H2AX

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	H2afx (synonyms: H2a.x, H2ax, Hist5-2ax)
Protein Name(s)	Histone H2AX H2a/x Histone H2A.X
External Links
UniProt	P27661
EMBL	X58069 Z35401 BC005468 BC010336
CCDS	CCDS23105.1
PIR	I48406
RefSeq	NP_034566.1
UniGene	Mm.245931
ProteinModelPortal	P27661
SMR	P27661
BioGrid	200313
IntAct	P27661
MINT	MINT-1864212
STRING	10090.ENSMUSP00000051432
PhosphoSite	P27661
MaxQB	P27661
PaxDb	P27661
PRIDE	P27661
Ensembl	ENSMUST00000052686
GeneID	15270
KEGG	mmu:15270
UCSC	uc009pcy.1
CTD	3014
MGI	MGI:102688
eggNOG	COG5262
GeneTree	ENSGT00760000118934
HOGENOM	HOG000234652
HOVERGEN	HBG009342
InParanoid	P27661
KO	K11251
OMA	TVGPKTP
OrthoDB	EOG7M0NTR
PhylomeDB	P27661
TreeFam	TF300137
Reactome	REACT_188819 REACT_188970 REACT_196580 REACT_198563 REACT_198597 REACT_198626 REACT_198629 REACT_200667 REACT_206033 REACT_214440 REACT_216539 REACT_222475 REACT_224328 REACT_226125 REACT_230172 REACT_244207 REACT_251314 REACT_256157 REACT_256555 REACT_259097 REACT_261629 REACT_268475 REACT_270446 REACT_27235 REACT_75800
NextBio	287897
PRO	PR:P27661
Proteomes	UP000000589
Bgee	P27661
CleanEx	MM_H2AFX
Genevestigator	P27661
GO	GO:0000785 GO:0005694 GO:0000781 GO:0000794 GO:0001673 GO:0000790 GO:0005654 GO:0000786 GO:0005634 GO:0005657 GO:0035861 GO:0001741 GO:0003684 GO:0006281 GO:0000724 GO:0051321 GO:0007283
Gene3D	1.10.20.10
InterPro	IPR009072 IPR007125 IPR002119
Pfam	PF00125
PRINTS	PR00620
SMART	SM00414
SUPFAM	SSF47113
PROSITE	PS00046

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0090734	site of DNA damage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16104	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:23039116^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20360685^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000605098 UniProtKB:P16104	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2448285 PANTHER:PTN000604564 PomBase:SPBC11B10.10c	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000179664 PANTHER:PTN000604564 UniProtKB:O97320 UniProtKB:Q7L7L0	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102688 PANTHER:PTN000604564 SGD:S000005372 UniProtKB:O75367 UniProtKB:Q9P0M6	C		Seeded From UniProt	complete
part_of	GO:0090734	site of DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071480	cellular response to gamma radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1566119	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	F		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23133398^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:22699483^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:11934988^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:11934988^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:15364958^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:15364958^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22297488^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21991325^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21911473^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20516196^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19176879^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000018)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17912366^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17475928^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000018)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14611631^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)\|part_of:(CL:0000020)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15604234^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11331621^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1566119	C		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:11934988^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:26358182^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:25675407^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:25634095^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:31484)	Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:23810942^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:23133398^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:22854038^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:22699483^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:21539824^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:20577743^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:19074312^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:18316482^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:18070917^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0001673	male germ cell nucleus	PMID:17696610^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:26490168^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:23555294^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:22711701^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:22164254^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:20551173^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:17696610^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:27760146^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:18694567^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:18283110^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:15657431^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:11934988^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0000781	chromosome, telomeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16104	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000724	double-strand break repair via homologous recombination	PMID:11934988^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156048	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0000077	DNA damage checkpoint	PMID:11934988^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156048	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZXP3 ensembl:ENSRNOP00000056469	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZXP3 ensembl:ENSRNOP00000056469	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZXP3 ensembl:ENSRNOP00000056469	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZXP3 ensembl:ENSRNOP00000056469	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZXP3 ensembl:ENSRNOP00000056469	C		Seeded From UniProt	complete
part_of	GO:0090734	site of DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	F		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16104 ensembl:ENSP00000434024	C		Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002119 InterPro:IPR007125	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002119 InterPro:IPR007125	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002119	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009072	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-912487 Reactome:R-MMU-912468 Reactome:R-MMU-912462 Reactome:R-MMU-912449 Reactome:R-MMU-912431 Reactome:R-MMU-912423 Reactome:R-MMU-912421	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0544	C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kogo, H et al. (2012) HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells 17 897-912 PubMed GONUTS page
↑ Artus, C et al. (2010) AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 29 1585-99 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Berkowitz, KM et al. (2012) Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 8 e1002996 PubMed GONUTS page
↑ ^5.0 ^5.1 Evans, EB et al. (2012) Localization and regulation of murine Esco2 during male and female meiosis. Biol. Reprod. 87 61 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Sengupta, S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J. Cell Biol. 166 801-13 PubMed GONUTS page
↑ Pelzel, HR et al. (2012) Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Invest. Ophthalmol. Vis. Sci. 53 1428-35 PubMed GONUTS page
↑ Chassot, AA et al. (2011) RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS ONE 6 e25641 PubMed GONUTS page
↑ Vaites, LP et al. (2011) The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol. Cell. Biol. 31 4513-23 PubMed GONUTS page
↑ Lian, I et al. (2010) The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 24 1106-18 PubMed GONUTS page
↑ Reynard, LN et al. (2009) The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biol. Reprod. 81 250-7 PubMed GONUTS page
↑ Paul, C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE 2 e989 PubMed GONUTS page
↑ Reynard, LN et al. (2007) Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR. Biol. Reprod. 77 329-35 PubMed GONUTS page
↑ Saunders, PT et al. (2003) Absence of mDazl produces a final block on germ cell development at meiosis. Reproduction 126 589-97 PubMed GONUTS page
↑ Polci, R et al. (2004) NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res. 64 8800-3 PubMed GONUTS page
↑ Chadwick, BP & Willard, HF (2001) Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum. Mol. Genet. 10 1101-13 PubMed GONUTS page
↑ Luangpraseuth-Prosper, A et al. (2015) TOPAZ1, a germ cell specific factor, is essential for male meiotic progression. Dev. Biol. 406 158-71 PubMed GONUTS page
↑ Tang, MC et al. (2015) Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice. PLoS Genet. 11 e1004964 PubMed GONUTS page
↑ Luo, M et al. (2015) Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. PLoS Genet. 11 e1004954 PubMed GONUTS page
↑ Shi, YQ et al. (2013) SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60. Gene 527 352-9 PubMed GONUTS page
↑ Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page
↑ Beyret, E & Lin, H (2011) Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev. Biol. 355 215-26 PubMed GONUTS page
↑ Saferali, A et al. (2010) Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm. Genome 21 377-87 PubMed GONUTS page
↑ Mihola, O et al. (2009) A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323 373-5 PubMed GONUTS page
↑ Yang, F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 22 682-91 PubMed GONUTS page
↑ Ryu, KY et al. (2008) The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol. Cell. Biol. 28 1136-46 PubMed GONUTS page
↑ ^28.0 ^28.1 Li, XC et al. (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet. 3 e130 PubMed GONUTS page
↑ Sun, X et al. (2016) FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma 125 237-52 PubMed GONUTS page
↑ Guiraldelli, MF et al. (2013) Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet. 9 e1003383 PubMed GONUTS page
↑ Llano, E et al. (2012) Meiotic cohesin complexes are essential for the formation of the axial element in mice. J. Cell Biol. 197 877-85 PubMed GONUTS page
↑ Kouznetsova, A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS ONE 6 e28255 PubMed GONUTS page
↑ Kumar, R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 24 1266-80 PubMed GONUTS page
↑ Finsterbusch, F et al. (2016) Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 12 e1006393 PubMed GONUTS page
↑ Soper, SF et al. (2008) Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev. Cell 15 285-97 PubMed GONUTS page
↑ Yang, F et al. (2008) Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J. Cell Biol. 180 673-9 PubMed GONUTS page
↑ Baarends, WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol. Cell. Biol. 25 1041-53 PubMed GONUTS page

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[PMID:26490168-29] Sun, X et al. (2016) FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma 125 237-52 PubMed GONUTS page

[PMID:23555294-30] Guiraldelli, MF et al. (2013) Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet. 9 e1003383 PubMed GONUTS page

[PMID:22711701-31] Llano, E et al. (2012) Meiotic cohesin complexes are essential for the formation of the axial element in mice. J. Cell Biol. 197 877-85 PubMed GONUTS page

[PMID:22164254-32] Kouznetsova, A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS ONE 6 e28255 PubMed GONUTS page

[PMID:20551173-33] Kumar, R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 24 1266-80 PubMed GONUTS page

[PMID:27760146-34] Finsterbusch, F et al. (2016) Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 12 e1006393 PubMed GONUTS page

[PMID:18694567-35] Soper, SF et al. (2008) Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev. Cell 15 285-97 PubMed GONUTS page

[PMID:18283110-36] Yang, F et al. (2008) Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J. Cell Biol. 180 673-9 PubMed GONUTS page

[PMID:15657431-37] Baarends, WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol. Cell. Biol. 25 1041-53 PubMed GONUTS page

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