GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:18316482
| Citation |
Yang, F, Gell, K, van der Heijden, GW, Eckardt, S, Leu, NA, Page, DC, Benavente, R, Her, C, Höög, C, McLaughlin, KJ and Wang, PJ (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 22:682-91 |
|---|---|
| Abstract |
Meiotic silencing of sex chromosomes may cause their depletion of meiosis-specific genes during evolution. Here, we challenge this hypothesis by reporting the identification of TEX11 as the first X-encoded meiosis-specific factor in mice. TEX11 forms discrete foci on synapsed regions of meiotic chromosomes and appears to be a novel constituent of meiotic nodules involved in recombination. Loss of TEX11 function causes chromosomal asynapsis and reduced crossover formation, leading to elimination of spermatocytes, respectively, at the pachytene and anaphase I stages. Specifically, TEX11-deficient spermatocytes with asynapsed autosomes undergo apoptosis at the pachytene stage, while those with only asynapsed sex chromosomes progress. However, cells that survive the pachytene stage display chromosome nondisjunction at the first meiotic division, resulting in cell death and male infertility. TEX11 interacts with SYCP2, which is an integral component of the synaptonemal complex lateral elements. Thus, TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes. |
| Links |
PubMed PMC2259036 Online version:10.1101/gad.1613608 |
| Keywords |
Animals; Apoptosis; Chromosomal Proteins, Non-Histone/metabolism; Chromosome Pairing/genetics; Crossing Over, Genetic/genetics; Female; Genes, X-Linked/physiology; Infertility, Male/genetics; Male; Mice; Mice, Mutant Strains; Proteins/genetics; Proteins/physiology; Spermatocytes/cytology; Spermatocytes/metabolism; Spermatocytes/physiology; X Chromosome/genetics; Y Chromosome/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
