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PMID:17912366
| Citation |
Paul, C, Povey, JE, Lawrence, NJ, Selfridge, J, Melton, DW and Saunders, PT (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE 2:e989 |
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| Abstract |
Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarriage. Mouse models allow us to investigate how deficiencies in DNA repair/damage response pathways impact on formation and function of male germ cells. We have investigated mice with deletions of ERCC1 (excision repair cross-complementing gene 1), MSH2 (MutS homolog 2, involved in mismatch repair pathway), and p53 (tumour suppressor gene implicated in elimination of germ cells with DNA damage). |
| Links |
PubMed PMC1991594 Online version:10.1371/journal.pone.0000989 |
| Keywords |
Animals; Chromatin/metabolism; DNA Damage; DNA Repair; DNA-Binding Proteins/genetics; Disease Models, Animal; Endonucleases/genetics; Gene Deletion; Germ Cells/cytology; Infertility, Male/genetics; Male; Mice; MutS Homolog 2 Protein/genetics; Spermatocytes/cytology; Testis/metabolism; Tumor Suppressor Protein p53/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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