MOUSE:FOXC2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxc2 (synonyms: Fkh14, Fkhl14, Mfh1)
Protein Name(s)	Forkhead box protein C2 Brain factor 3 BF-3 Forkhead-related protein FKHL14 Mesenchyme fork head protein 1 MFH-1 protein Transcription factor FKH-14
External Links
UniProt	Q61850
EMBL	X92499 Y08222 X74040 AK076319 S63607
CCDS	CCDS40499.1
PIR	S34472
RefSeq	NP_038547.2
UniGene	Mm.14092
ProteinModelPortal	Q61850
SMR	Q61850
PhosphoSite	Q61850
MaxQB	Q61850
PRIDE	Q61850
Ensembl	ENSMUST00000054691
GeneID	14234
KEGG	mmu:14234
UCSC	uc012glx.1
CTD	2303
MGI	MGI:1347481
eggNOG	COG5025
GeneTree	ENSGT00760000118904
HOGENOM	HOG000007939
HOVERGEN	HBG051640
InParanoid	Q61850
KO	K09396
OMA	LNHLPGH
OrthoDB	EOG7C8GHD
PhylomeDB	Q61850
TreeFam	TF316127
NextBio	285515
PRO	PR:Q61850
Proteomes	UP000000589
Bgee	Q61850
CleanEx	MM_FOXC2
ExpressionAtlas	Q61850
Genevestigator	Q61850
GO	GO:0005634 GO:0031490 GO:0003677 GO:0001077 GO:0003705 GO:0043565 GO:0003700 GO:0044212 GO:0048844 GO:0001568 GO:0001974 GO:0043010 GO:0060038 GO:0008283 GO:0030199 GO:0048701 GO:0035050 GO:0048704 GO:0048703 GO:0072011 GO:0072144 GO:0072112 GO:0007507 GO:0003007 GO:0008286 GO:0001822 GO:0001945 GO:0001946 GO:0001656 GO:1902257 GO:0000122 GO:0014032 GO:0007219 GO:0001503 GO:0048341 GO:0048343 GO:0001569 GO:0033630 GO:0090050 GO:0010595 GO:0033625 GO:0045944 GO:0045893 GO:0035470 GO:0050880 GO:0046620 GO:0009725 GO:0001501 GO:0001756 GO:0006366 GO:0001657 GO:0048010 GO:0055010
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033625	positive regulation of integrin activation	PMID:18579532^[1]	ECO:0000314			P		Figure 1A: Foxc2 induces the expression of Itgb3 and Itgb5, (components of avβ3 and �αvβ5 integrin heterodimers respectively) and fibronectin (FN) a ligand for integrin avβ3.	complete
	GO:0010843	promoter binding	PMID:18579532^[1]	ECO:0000314			F		Figure 3C: Foxc2 activates the proximal Itgb3 promoter in a dose-dependent manner.	complete
	GO:0001937	negative regulation of endothelial cell proliferation	PMID:18579532^[1]	ECO:0000314			P		Figure 4: Although VEGF augmented cell division Foxc2 overexpression along with VEGF did not show further increase in proliferation compared with the control VEGF cells. This indicates that Foxc2 does not stimulate the proliferation of endothelial cells	complete
	GO:0033627	cell adhesion mediated by integrin	PMID:18579532^[1]	ECO:0000314			P		Figure 5A: Adhesion assays showed that Foxc2 significantly increased adhesiveness compared with the control cells.	complete
	GO:0010595	positive regulation of endothelial cell migration	PMID:18579532^[1]	ECO:0000314			P		Figure 5C: Wound close assay showed that Foxc2 enhanced endothelial cell migration	complete
	GO:0045941	positive regulation of transcription	PMID:18579532^[1]	ECO:0000314			P		Figure 3E: Foxc2 directly induces Itgb3 expression through Itgb3 distal and proximal HHRs in endothelial cells	complete
	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:18579532^[1]	ECO:0000314			P		Figure 7A: The aortic ring assay showed abundant formation of vascular sprouts from aortic rings infected with Ad-Foxc2 compared with the control	complete
	GO:0035470		PMID:18579532^[1]	ECO:0000314					Figure 5B-C: Wound closure assays showed that Foxc2 dramatically enhanced endothelial cell migration	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:11551504^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18187037^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:18187037^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18187037^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035470	positive regulation of vascular wound healing	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033625	positive regulation of integrin activation	PMID:18579532^[1]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18579532^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9169153^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9169153^[4]	ECO:0000305	curator inference used in manual assertion	GO:0044212	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	PMID:9169153^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:11562355^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	regulates_o_occurs_in:(CL:0000333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072144	glomerular mesangial cell development	PMID:16498405^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P	occurs_in:(EMAPA:28239) results_in_development_of:(CL:0000650)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072112	glomerular visceral epithelial cell differentiation	PMID:16498405^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P	occurs_in:(EMAPA:28239) results_in_acquisition_of_features_of:(CL:0000653)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072011	glomerular endothelium development	PMID:16498405^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060038	cardiac muscle cell proliferation	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	occurs_in:(EMAPA:16105)\|occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	has_participant:(EMAPA:16105)\|has_participant:(EMAPA:16346)\|has_participant:(EMAPA:16350)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050880	regulation of blood vessel size	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	regulates_o_has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048844	artery morphogenesis	PMID:9409679^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048844	artery morphogenesis	PMID:10479458^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:9409679^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048703	embryonic viscerocranium morphogenesis	PMID:9409679^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:9106663^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048343	paraxial mesodermal cell fate commitment	PMID:9106663^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048341	paraxial mesoderm formation	PMID:11562355^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	occurs_in:(EMAPA:16105) occurs_in:(CL:0000071)\|occurs_in:(EMAPA:16164) occurs_in:(CL:0000071)\|occurs_in:(EMAPA:16062) occurs_in:(CL:0000071)\|occurs_in:(EMAPA:16105) occurs_in:(CL:0000115)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046620	regulation of organ growth	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	regulates_o_occurs_in:(EMAPA:16105)\|regulates_o_occurs_in:(EMAPA:16346)\|regulates_o_occurs_in:(EMAPA:16350)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16678147^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1859388)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:10767326^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035050	embryonic heart tube development	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	results_in_development_of:(EMAPA:16204)\|results_in_development_of:(EMAPA:16354)	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030199	collagen fibril organization	PMID:10767326^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014032	neural crest cell development	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	occurs_in:(EMAPA:16118) results_in_development_of:(CL:0000333)\|occurs_in(EMAPA:16272) results_in_development_of:(CL:0000333)\|occurs_in(EMAPA:16399) results_in_development_of:(CL:0000333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009725	response to hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:9106663^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P	occurs_in:(EMAPA:31159)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:10364424^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P	occurs_in:(EMAPA:31159)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	results_in_development_of:(EMAPA:16105)\|results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15664398^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105923	P	results_in_development_of:(EMAPA:16827)\|results_in_development_of:(EMAPA:17174)\|results_in_development_of:(EMAPA:16688)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:10479458^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:11562355^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8325367^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621703	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:16839542^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P	has_participant:(EMAPA:16105)\|has_participant:(EMAPA:16346)\|has_participant:(EMAPA:16350)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	PMID:11562355^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001946	lymphangiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001945	lymph vessel development	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:10704385^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001657	ureteric bud development	PMID:10704385^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:16498405^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P	results_in_development_of:(EMAPA:28236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:15664398^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105923	P	occurs_in:(EMAPA:16204)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	PMID:9106663^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857865	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:10364424^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:10364424^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857740	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:16678147^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347466	F	has_regulation_target:(MGI:MGI:1859388)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63246 ensembl:ENSRNOP00000065254	F		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	C		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99958 ensembl:ENSP00000326371	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 Hayashi, H et al. (2008) The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J. Biol. Chem. 283 23791-800 PubMed GONUTS page
↑ Cederberg, A et al. (2001) FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106 563-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hayashi, H & Kume, T (2008) Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem. Biophys. Res. Commun. 367 584-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Miura, N et al. (1997) Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. Genomics 41 489-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kume, T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15 2470-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Seo, S & Kume, T (2006) Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev. Biol. 296 421-36 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Takemoto, M et al. (2006) Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 25 1160-74 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Seo, S et al. (2006) The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev. Biol. 294 458-70 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Iida, K et al. (1997) Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124 4627-38 PubMed GONUTS page
↑ ^11.0 ^11.1 Winnier, GE et al. (1999) Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev. Biol. 213 418-31 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Winnier, GE et al. (1997) The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 11 926-40 PubMed GONUTS page
↑ ^13.0 ^13.1 Smith, RS et al. (2000) Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Hum. Mol. Genet. 9 1021-32 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Furumoto, TA et al. (1999) Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev. Biol. 210 15-29 PubMed GONUTS page
↑ ^15.0 ^15.1 Kanzaki-Kato, N et al. (2005) Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc. Res. 65 711-8 PubMed GONUTS page
↑ Miura, N et al. (1993) MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett. 326 171-6 PubMed GONUTS page
↑ ^17.0 ^17.1 Kume, T et al. (2000) Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development 127 1387-95 PubMed GONUTS page

[PMID:18579532-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 Hayashi, H et al. (2008) The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J. Biol. Chem. 283 23791-800 PubMed GONUTS page

[PMID:11551504-2] Cederberg, A et al. (2001) FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106 563-73 PubMed GONUTS page

[PMID:18187037-3] 3.0 ^3.1 ^3.2 Hayashi, H & Kume, T (2008) Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem. Biophys. Res. Commun. 367 584-9 PubMed GONUTS page

[PMID:9169153-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Miura, N et al. (1997) Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. Genomics 41 489-92 PubMed GONUTS page

[PMID:11562355-5] 5.0 ^5.1 ^5.2 ^5.3 Kume, T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15 2470-82 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16839542-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Seo, S & Kume, T (2006) Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev. Biol. 296 421-36 PubMed GONUTS page

[PMID:16498405-8] 8.0 ^8.1 ^8.2 ^8.3 Takemoto, M et al. (2006) Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 25 1160-74 PubMed GONUTS page

[PMID:16678147-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Seo, S et al. (2006) The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev. Biol. 294 458-70 PubMed GONUTS page

[PMID:9409679-10] 10.0 ^10.1 ^10.2 Iida, K et al. (1997) Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124 4627-38 PubMed GONUTS page

[PMID:10479458-11] 11.0 ^11.1 Winnier, GE et al. (1999) Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev. Biol. 213 418-31 PubMed GONUTS page

[PMID:9106663-12] 12.0 ^12.1 ^12.2 ^12.3 Winnier, GE et al. (1997) The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 11 926-40 PubMed GONUTS page

[PMID:10767326-13] 13.0 ^13.1 Smith, RS et al. (2000) Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Hum. Mol. Genet. 9 1021-32 PubMed GONUTS page

[PMID:10364424-14] 14.0 ^14.1 ^14.2 Furumoto, TA et al. (1999) Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev. Biol. 210 15-29 PubMed GONUTS page

[PMID:15664398-15] 15.0 ^15.1 Kanzaki-Kato, N et al. (2005) Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc. Res. 65 711-8 PubMed GONUTS page

[PMID:8325367-16] Miura, N et al. (1993) MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett. 326 171-6 PubMed GONUTS page

[PMID:10704385-17] 17.0 ^17.1 Kume, T et al. (2000) Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development 127 1387-95 PubMed GONUTS page

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MOUSE:FOXC2

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