PMID:15664398

Citation	Kanzaki-Kato, N, Tamakoshi, T, Fu, Y, Chandra, A, Itakura, T, Uezato, T, Tanaka, T, Clouthier, DE, Sugiyama, T, Yanagisawa, M and Miura, N (2005) Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc. Res. 65:711-8
Abstract	Foxc2/MFH-1 is a member of the forkhead family of transcription factors and Foxc2-deficient mice exhibit aortic arch anomalies (type B interruption of the aortic arch). Endothelin receptor type-A (ETA) is one of the two known endothelin receptors that belong to the G-protein-coupled receptor family. ETA-deficient mice show defects in the great arteries, primarily type B interruption of the aortic arch. Based on similar phenotypes in the cardiovascular system of Foxc2- and ETA-deficient mice, we investigated whether Foxc2 and ETA have a close relationship in aortic arch patterning.
Links	PubMed Online version:10.1016/j.cardiores.2004.10.017
Keywords	Animals; Aorta, Thoracic/abnormalities; Aorta, Thoracic/embryology; Body Patterning/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; DNA-Binding Proteins/physiology; Fetal Death/genetics; Forkhead Transcription Factors; Gene Expression Regulation, Developmental/physiology; Genotype; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptor, Endothelin A/genetics; Receptor, Endothelin A/metabolism; Receptor, Endothelin A/physiology; Reverse Transcriptase Polymerase Chain Reaction/methods; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription Factors/physiology; Truncus Arteriosus, Persistent/genetics
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