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PMID:8325367
| Citation |
Miura, N, Wanaka, A, Tohyama, M and Tanaka, K (1993) MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett. 326:171-6 |
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| Abstract |
We have isolated a novel mouse gene, MFH-1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH-1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH-1 protein could bind to the HNF3 binding site. MFH-1 is expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH-1 might be involved in the formation of special mesenchymal tissues. |
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| Keywords |
Amino Acid Sequence; Animals; Brain/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; Drosophila; Embryo, Mammalian/metabolism; Embryo, Nonmammalian; Embryonic and Fetal Development; Forkhead Transcription Factors; Gene Expression; Hepatocyte Nuclear Factor 3-alpha; Hepatocyte Nuclear Factor 3-beta; Hepatocyte Nuclear Factor 3-gamma; Mesoderm/metabolism; Mice; Molecular Sequence Data; Nuclear Proteins/chemistry; Nuclear Proteins/genetics; Polymerase Chain Reaction; RNA, Messenger/analysis; Rats; Sequence Homology; Transcription Factors/chemistry; Transcription Factors/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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