PMID:9169153

Citation	Miura, N, Iida, K, Kakinuma, H, Yang, XL and Sugiyama, T (1997) Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. Genomics 41:489-92
Abstract	The very recently found evolutionarily conserved DNA-binding domain of 100 amino acids, termed the fork head domain, emerged from a sequence comparison of the rat hepatocyte transcription factor HNF-3 alpha and the homeotic gene fork head of Drosophila. We previously isolated a new member of this family, the mesenchyme fork head-1 (MFH-1) gene, which is expressed in developing mesenchyme. Here we describe the isolation of the mouse (MFH-1) and human (FKHL14) chromosomal MFH-1 genes and the determination of the gene and protein structures of MFH-1. We found that the MFH-1 gene has no introns and that the identity of the amino acid sequences of mouse and human MFH-1 proteins is 94%. We also investigated the transcriptional activity of the mouse and human MFH-1 proteins and found that both proteins act as positive transactivators.
Links	PubMed Online version:10.1006/geno.1997.4695
Keywords	Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Conserved Sequence; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila; Evolution, Molecular; Forkhead Transcription Factors; Humans; Mice; Molecular Sequence Data; Molecular Structure; Oligodeoxyribonucleotides/genetics; Rats; Sequence Homology, Amino Acid; Trans-Activators/chemistry; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription Factors/metabolism
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