MOUSE:CXA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gja1 (synonyms: Cxn-43)
Protein Name(s)	Gap junction alpha-1 protein Connexin-43 Cx43 Gap junction 43 kDa heart protein
External Links
UniProt	P23242
EMBL	M61896 M63801 X62836 X61576 AK029291 AK036979 AK145692 AK165986 CT010327 CH466540 BC006894
CCDS	CCDS23851.1
PIR	A39802
RefSeq	NP_034418.1 XP_006512604.1
UniGene	Mm.378921
ProteinModelPortal	P23242
SMR	P23242
BioGrid	199923
DIP	DIP-29207N
IntAct	P23242
MINT	MINT-1326689
PhosphoSite	P23242
MaxQB	P23242
PaxDb	P23242
PRIDE	P23242
Ensembl	ENSMUST00000068581
GeneID	14609
KEGG	mmu:14609
UCSC	uc007fcc.2
CTD	2697
MGI	MGI:95713
eggNOG	NOG45368
GeneTree	ENSGT00760000118780
HOVERGEN	HBG009576
InParanoid	P23242
KO	K07372
OMA	GANVDMH
OrthoDB	EOG7P2XSS
PhylomeDB	P23242
TreeFam	TF329606
Reactome	REACT_209040 REACT_216289 REACT_218773 REACT_220352 REACT_224600 REACT_226013 REACT_227366
ChiTaRS	Gja1
NextBio	286404
PRO	PR:P23242
Proteomes	UP000000589
Bgee	P23242
CleanEx	MM_GJA1
ExpressionAtlas	P23242
Genevestigator	P23242
GO	GO:0016324 GO:0030054 GO:0005911 GO:0005922 GO:0043292 GO:0005737 GO:0005829 GO:0005769 GO:0070062 GO:0005916 GO:0005921 GO:0005794 GO:0016021 GO:0014704 GO:0005882 GO:0016328 GO:0005764 GO:0016020 GO:0045121 GO:0005741 GO:0005771 GO:0005886 GO:0048487 GO:0005243 GO:0005102 GO:0097110 GO:0004871 GO:0007512 GO:0006915 GO:0015867 GO:0003294 GO:0048514 GO:0061337 GO:0010643 GO:0010644 GO:0045216 GO:0007267 GO:0071260 GO:0002544 GO:0042733 GO:0035050 GO:0003158 GO:0003347 GO:0002070 GO:0090162 GO:0007507 GO:0001947 GO:0001701 GO:0002088 GO:0060156 GO:0060044 GO:2000279 GO:0001937 GO:0010629 GO:0061045 GO:0001764 GO:0048812 GO:0001649 GO:2000987 GO:0010652 GO:0007204 GO:0010628 GO:0003104 GO:0043123 GO:0032024 GO:0045669 GO:0045732 GO:0045844 GO:0045907 GO:0045909 GO:0051259 GO:0060371 GO:0060312 GO:0030500 GO:0046850 GO:0051924 GO:0008016 GO:2000810 GO:0060373 GO:0060307 GO:0034405 GO:0009749 GO:0043434 GO:0009268 GO:0043403 GO:0010232
InterPro	IPR000500 IPR002261 IPR013124 IPR019570 IPR017990 IPR013092
PANTHER	PTHR11984
Pfam	PF00029 PF03508 PF10582
PRINTS	PR00206 PR01132
SMART	SM00037 SM01089
PROSITE	PS00407 PS00408

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005243	gap junction channel activity	PMID:22197781^[1]	ECO:0000314			F		Table 1: Interactions between gap junction proteins	complete CACAO 5149
part_of	GO:0016324	apical plasma membrane	PMID:29366904^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:17591950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27626200^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
enables	GO:0055077	gap junction hemi-channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
involved_in	GO:0099111	microtubule-based transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17302-5	P		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:29366904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21844382^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	PMID:25270829^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:17591950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	P		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:7892609^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:7892609^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:14699011^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05480	F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:14699011^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P39447	F		Seeded From UniProt	complete
involved_in	GO:0071467	cellular response to pH	PMID:14699011^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14699011^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:26403541^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:26403541^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:15181016^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	PMID:25270829^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:19544087^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51637	F		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:17884088^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	PMID:16917092^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	PMID:26648560^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035050	embryonic heart tube development	PMID:14732399^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034220	ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030500	regulation of bone mineralization	PMID:21346198^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445468 MGI:MGI:3776013	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:15601660^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:9620080^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002224)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:9620080^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002224)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19723622^[20]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015867	ATP transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
enables	GO:0015075	ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:27799555^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:18178574^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32746) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:15272007^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32748) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010652	positive regulation of cell communication by chemical coupling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010644	cell communication by electrical coupling	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010644	cell communication by electrical coupling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010643	cell communication by chemical coupling	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:19439426^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:19439426^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445472	P	has_regulation_target:(MGI:MGI:98297)\|has_regulation_target:(MGI:MGI:88177)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010232	vascular transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009268	response to pH	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008016	regulation of heart contraction	PMID:11397787^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	regulates_o_occurs_in:(EMAPA:17331)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008016	regulation of heart contraction	PMID:11179202^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386742,MGI:MGI:3051881	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007512	adult heart development	PMID:9486664^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:16624854^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176205,MGI:MGI:3051881	P	results_in_development_of:(EMAPA:17342)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:11397787^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007154	cell communication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:20089884^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002324)	Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:20086016^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:14595769^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:12738802^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:11922902^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32748) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	PMID:11732910^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21296051^[35]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32746) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:15331634^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17164264^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15331634^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000127)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15331634^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000987	positive regulation of behavioral fear response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000810	regulation of bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
enables	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	F		Seeded From UniProt	complete
enables	GO:0071253	connexin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061337	cardiac conduction	PMID:9109444^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	occurs_in:(EMAPA:17331)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061337	cardiac conduction	PMID:10969038^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061045	negative regulation of wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	PMID:10969038^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95716	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	PMID:9109444^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	PMID:10969038^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	PMID:10969038^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	PMID:10969038^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95716	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	PMID:10969038^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060156	milk ejection reflex	PMID:20089884^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2682016	P	has_participant:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055085	transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
enables	GO:0055077	gap junction hemi-channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051924	regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048812	neuron projection morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:16624854^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:3051881	P	has_participant:(EMAPA:36533)\|has_participant:(EMAPA:36531)\|has_participant:(EMAPA:36532)	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046850	regulation of bone remodeling	PMID:21346198^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445468 MGI:MGI:3776013	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045844	positive regulation of striated muscle tissue development	PMID:15601660^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2676327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:21934140^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045216	cell-cell junction organization	PMID:9620080^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	has_participant:(EMAPA:17841)\|has_participant:(EMAPA:32871)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043403	skeletal muscle tissue regeneration	PMID:15601660^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	PMID:21708977^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:19439426^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445472	P	has_participant:(EMAPA:17428)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9620080^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002224)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:15084279^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000127)	Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:11397787^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:15331634^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z1M0	F	occurs_in:(CL:0000235) has_input:(MGI:MGI:1339957)\|occurs_in(CL:0000581) has_input:(MGI:MGI:1339957)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003294	atrial ventricular junction remodeling	PMID:10969038^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95716	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002544	chronic inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:9620080^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002070	epithelial cell maturation	PMID:16624854^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176205,MGI:MGI:3051881	P	occurs_in:(EMAPA:16532) results_in_maturation_of:(CL:0000710)\|occurs_in(EMAPA:16535) results_in_maturation_of:(CL:0000710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:9486664^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2690	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:12638734^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000031)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9486664^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857177	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:12606326^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445468 MGI:MGI:3776013	P		Seeded From UniProt	complete
involved_in	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0086075	P		Seeded From UniProt	complete
involved_in	GO:2000987	positive regulation of behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:1905867	epididymis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0071253	connexin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
involved_in	GO:0015867	ATP transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0010652	positive regulation of cell communication by chemical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0010232	vascular transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0003158	endothelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0002544	chronic inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	F		Seeded From UniProt	complete
enables	GO:0055077	gap junction hemi-channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	C		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	F		Seeded From UniProt	complete
enables	GO:0015075	ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	F		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	C		Seeded From UniProt	complete
involved_in	GO:0010644	cell communication by electrical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	P		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17302 ensembl:ENSP00000497788	F		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000500 InterPro:IPR002261 InterPro:IPR017990	C		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000500 InterPro:IPR017990	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	P		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	F		Seeded From UniProt	complete
enables	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling	PMID:26403541^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090162	establishment of epithelial cell polarity	PMID:20299672^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060312	regulation of blood vessel remodeling	PMID:20299672^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003347	epicardial cell to mesenchymal cell transition	PMID:20299672^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0303 UniProtKB-SubCell:SL-0124	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hervé, JC et al. (2012) Gap junctional channels are parts of multiprotein complexes. Biochim. Biophys. Acta 1818 1844-65 PubMed GONUTS page
↑ ^2.0 ^2.1 Akanuma, SI et al. (2018) Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins. Exp. Eye Res. 168 128-137 PubMed GONUTS page
↑ ^3.0 ^3.1 Brehm, R et al. (2007) A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis. Am. J. Pathol. 171 19-31 PubMed GONUTS page
↑ Zhu, Y et al. (2016) Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24 420-433 PubMed GONUTS page
↑ Mendoza-Naranjo, A et al. (2011) Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation. J. Immunol. 187 3121-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Xu, H et al. (2015) Connexin 43 channels are essential for normal bone structure and osteocyte viability. J. Bone Miner. Res. 30 436-48 PubMed GONUTS page
↑ ^7.0 ^7.1 Reaume, AG et al. (1995) Cardiac malformation in neonatal mice lacking connexin43. Science 267 1831-4 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Sharma, P et al. (2015) Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun 6 8391 PubMed GONUTS page
↑ Gellhaus, A et al. (2004) Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J. Biol. Chem. 279 36931-42 PubMed GONUTS page
↑ Liu, L et al. (2010) Connexin43 interacts with Caveolin-3 in the heart. Mol. Biol. Rep. 37 1685-91 PubMed GONUTS page
↑ Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page
↑ Yang, Z et al. (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ. Res. 99 646-55 PubMed GONUTS page
↑ Yu, F et al. (2016) Connexin43 knockdown in bone marrow‑derived dendritic cells by small interfering RNA leads to a diminished T-cell stimulation. Mol Med Rep 13 895-900 PubMed GONUTS page
↑ Simon, AM et al. (2004) Heart and head defects in mice lacking pairs of connexins. Dev. Biol. 265 369-83 PubMed GONUTS page
↑ ^16.0 ^16.1 Watkins, M et al. (2011) Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling. Mol. Biol. Cell 22 1240-51 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Araya, R et al. (2005) Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J. Cell. Sci. 118 27-37 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Gao, Y & Spray, DC (1998) Structural changes in lenses of mice lacking the gap junction protein connexin43. Invest. Ophthalmol. Vis. Sci. 39 1198-209 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 Butkevich, E et al. (2004) Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr. Biol. 14 650-8 PubMed GONUTS page
↑ Sato, M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J. Biol. Chem. 284 31431-40 PubMed GONUTS page
↑ Rivera-Torres, J et al. (2016) Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc. Natl. Acad. Sci. U.S.A. 113 E7250-E7259 PubMed GONUTS page
↑ Domínguez, JN et al. (2008) Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development. Cardiovasc. Res. 78 45-52 PubMed GONUTS page
↑ Malhotra, JD et al. (2004) Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J. Biol. Chem. 279 40748-54 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Dobrowolski, R et al. (2009) Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum. Mol. Genet. 18 2899-911 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Vaidya, D et al. (2001) Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ. Res. 88 1196-202 PubMed GONUTS page
↑ Gutstein, DE et al. (2001) Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ. Res. 88 333-9 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Ya, J et al. (1998) Heart defects in connexin43-deficient mice. Circ. Res. 82 360-6 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Liu, S et al. (2006) Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development 133 2063-73 PubMed GONUTS page
↑ ^29.0 ^29.1 Plante, I et al. (2010) Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol. Reprod. 82 837-47 PubMed GONUTS page
↑ Bhalla-Gehi, R et al. (2010) Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J. Biol. Chem. 285 9147-60 PubMed GONUTS page
↑ Forge, A et al. (2003) Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals. J. Comp. Neurol. 467 207-31 PubMed GONUTS page
↑ Iijima, Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J. 17 1361-3 PubMed GONUTS page
↑ Johnson, CM et al. (2002) Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc. Res. 53 921-35 PubMed GONUTS page
↑ Zhang, JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40 14898-906 PubMed GONUTS page
↑ Thomas, NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem. Biophys. Res. Commun. 406 117-22 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 Fortes, FS et al. (2004) Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors. J. Cell. Sci. 117 4717-26 PubMed GONUTS page
↑ Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page
↑ ^38.0 ^38.1 Guerrero, PA et al. (1997) Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J. Clin. Invest. 99 1991-8 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 ^39.6 Kirchhoff, S et al. (2000) Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice. Circ. Res. 87 399-405 PubMed GONUTS page
↑ Chaible, LM et al. (2011) Delayed osteoblastic differentiation and bone development in Cx43 knockout mice. Toxicol Pathol 39 1046-55 PubMed GONUTS page
↑ Crippa, S et al. (2011) miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J. Cell Biol. 193 1197-212 PubMed GONUTS page
↑ Fushiki, S et al. (2003) Changes in neuronal migration in neocortex of connexin43 null mutant mice. J. Neuropathol. Exp. Neurol. 62 304-14 PubMed GONUTS page
↑ Yang, G et al. (2003) Analysis of germ cell nuclear factor transcripts and protein expression during spermatogenesis. Biol. Reprod. 68 1620-30 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:22197781-1] Hervé, JC et al. (2012) Gap junctional channels are parts of multiprotein complexes. Biochim. Biophys. Acta 1818 1844-65 PubMed GONUTS page

[PMID:29366904-2] 2.0 ^2.1 Akanuma, SI et al. (2018) Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins. Exp. Eye Res. 168 128-137 PubMed GONUTS page

[PMID:17591950-3] 3.0 ^3.1 Brehm, R et al. (2007) A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis. Am. J. Pathol. 171 19-31 PubMed GONUTS page

[PMID:27626200-4] Zhu, Y et al. (2016) Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24 420-433 PubMed GONUTS page

[PMID:21844382-5] Mendoza-Naranjo, A et al. (2011) Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation. J. Immunol. 187 3121-32 PubMed GONUTS page

[PMID:25270829-6] 6.0 ^6.1 Xu, H et al. (2015) Connexin 43 channels are essential for normal bone structure and osteocyte viability. J. Bone Miner. Res. 30 436-48 PubMed GONUTS page

[PMID:7892609-7] 7.0 ^7.1 Reaume, AG et al. (1995) Cardiac malformation in neonatal mice lacking connexin43. Science 267 1831-4 PubMed GONUTS page

[PMID:14699011-8] 8.0 ^8.1 ^8.2 ^8.3 Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page

[PMID:26403541-9] 9.0 ^9.1 ^9.2 Sharma, P et al. (2015) Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun 6 8391 PubMed GONUTS page

[PMID:15181016-10] Gellhaus, A et al. (2004) Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J. Biol. Chem. 279 36931-42 PubMed GONUTS page

[PMID:19544087-11] Liu, L et al. (2010) Connexin43 interacts with Caveolin-3 in the heart. Mol. Biol. Rep. 37 1685-91 PubMed GONUTS page

[PMID:17884088-12] Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page

[PMID:16917092-13] Yang, Z et al. (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ. Res. 99 646-55 PubMed GONUTS page

[PMID:26648560-14] Yu, F et al. (2016) Connexin43 knockdown in bone marrow‑derived dendritic cells by small interfering RNA leads to a diminished T-cell stimulation. Mol Med Rep 13 895-900 PubMed GONUTS page

[PMID:14732399-15] Simon, AM et al. (2004) Heart and head defects in mice lacking pairs of connexins. Dev. Biol. 265 369-83 PubMed GONUTS page

[PMID:21346198-16] 16.0 ^16.1 Watkins, M et al. (2011) Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling. Mol. Biol. Cell 22 1240-51 PubMed GONUTS page

[PMID:15601660-17] 17.0 ^17.1 ^17.2 Araya, R et al. (2005) Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J. Cell. Sci. 118 27-37 PubMed GONUTS page

[PMID:9620080-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Gao, Y & Spray, DC (1998) Structural changes in lenses of mice lacking the gap junction protein connexin43. Invest. Ophthalmol. Vis. Sci. 39 1198-209 PubMed GONUTS page

[PMID:15084279-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 Butkevich, E et al. (2004) Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr. Biol. 14 650-8 PubMed GONUTS page

[PMID:19723622-20] Sato, M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J. Biol. Chem. 284 31431-40 PubMed GONUTS page

[PMID:27799555-21] Rivera-Torres, J et al. (2016) Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc. Natl. Acad. Sci. U.S.A. 113 E7250-E7259 PubMed GONUTS page

[PMID:18178574-22] Domínguez, JN et al. (2008) Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development. Cardiovasc. Res. 78 45-52 PubMed GONUTS page

[PMID:15272007-23] Malhotra, JD et al. (2004) Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J. Biol. Chem. 279 40748-54 PubMed GONUTS page

[PMID:19439426-24] 24.0 ^24.1 ^24.2 Dobrowolski, R et al. (2009) Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum. Mol. Genet. 18 2899-911 PubMed GONUTS page

[PMID:11397787-25] 25.0 ^25.1 ^25.2 Vaidya, D et al. (2001) Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ. Res. 88 1196-202 PubMed GONUTS page

[PMID:11179202-26] Gutstein, DE et al. (2001) Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ. Res. 88 333-9 PubMed GONUTS page

[PMID:9486664-27] 27.0 ^27.1 ^27.2 Ya, J et al. (1998) Heart defects in connexin43-deficient mice. Circ. Res. 82 360-6 PubMed GONUTS page

[PMID:16624854-28] 28.0 ^28.1 ^28.2 Liu, S et al. (2006) Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development 133 2063-73 PubMed GONUTS page

[PMID:20089884-29] 29.0 ^29.1 Plante, I et al. (2010) Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol. Reprod. 82 837-47 PubMed GONUTS page

[PMID:20086016-30] Bhalla-Gehi, R et al. (2010) Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J. Biol. Chem. 285 9147-60 PubMed GONUTS page

[PMID:14595769-31] Forge, A et al. (2003) Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals. J. Comp. Neurol. 467 207-31 PubMed GONUTS page

[PMID:12738802-32] Iijima, Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J. 17 1361-3 PubMed GONUTS page

[PMID:11922902-33] Johnson, CM et al. (2002) Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc. Res. 53 921-35 PubMed GONUTS page

[PMID:11732910-34] Zhang, JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40 14898-906 PubMed GONUTS page

[PMID:21296051-35] Thomas, NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem. Biophys. Res. Commun. 406 117-22 PubMed GONUTS page

[PMID:15331634-36] 36.0 ^36.1 ^36.2 ^36.3 Fortes, FS et al. (2004) Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors. J. Cell. Sci. 117 4717-26 PubMed GONUTS page

[PMID:17164264-37] Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page

[PMID:9109444-38] 38.0 ^38.1 Guerrero, PA et al. (1997) Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J. Clin. Invest. 99 1991-8 PubMed GONUTS page

[PMID:10969038-39] 39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 ^39.6 Kirchhoff, S et al. (2000) Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice. Circ. Res. 87 399-405 PubMed GONUTS page

[PMID:21934140-40] Chaible, LM et al. (2011) Delayed osteoblastic differentiation and bone development in Cx43 knockout mice. Toxicol Pathol 39 1046-55 PubMed GONUTS page

[PMID:21708977-41] Crippa, S et al. (2011) miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J. Cell Biol. 193 1197-212 PubMed GONUTS page

[PMID:12638734-42] Fushiki, S et al. (2003) Changes in neuronal migration in neocortex of connexin43 null mutant mice. J. Neuropathol. Exp. Neurol. 62 304-14 PubMed GONUTS page

[PMID:12606326-43] Yang, G et al. (2003) Analysis of germ cell nuclear factor transcripts and protein expression during spermatogenesis. Biol. Reprod. 68 1620-30 PubMed GONUTS page

[PMID:20299672-44] 44.0 ^44.1 ^44.2 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

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MOUSE:CXA1

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