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Johnson, CM, Kanter, EM, Green, KG, Laing, JG, Betsuyaku, T, Beyer, EC, Steinberg, TH, Saffitz, JE and Yamada, KA (2002) Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc. Res. 53:921-35
Adult ventricular myocytes express two gap junction channel proteins: connexin43 (Cx43) and connexin45 (Cx45). Cx43-deficient mice exhibit slow ventricular epicardial conduction, suggesting that Cx43 plays an important role in intercellular coupling in the ventricle. Cx45 is much less abundant than Cx43 in working ventricular myocytes. Its role in ventricular conduction has not been defined, nor is it known whether expression or distribution of Cx45 is altered in Cx43-deficient mice. The present study was undertaken to determine (1) whether expression of Cx45 is upregulated and (2) whether gap junction structure and distribution are altered in Cx43-deficient mice.
Animals; Animals, Newborn; Connexin 43/metabolism; Connexins/deficiency; Connexins/metabolism; Gap Junctions/metabolism; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Fluorescence; Myocardium/metabolism
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