MOUSE:CRYAB

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cryab (synonyms: Crya2)
Protein Name(s)	Alpha-crystallin B chain Alpha(B)-crystallin P23
External Links
UniProt	P23927
EMBL	M63170 M73741 BC010768 M25770
CCDS	CCDS23172.1
PIR	A39608
RefSeq	NP_001276711.1 NP_001276713.1 NP_001276714.1 NP_034094.1 XP_006510033.1
UniGene	Mm.178
ProteinModelPortal	P23927
SMR	P23927
BioGrid	198909
DIP	DIP-31060N
IntAct	P23927
MINT	MINT-1591396
PhosphoSite	P23927
SWISS-2DPAGE	P23927
MaxQB	P23927
PaxDb	P23927
PRIDE	P23927
Ensembl	ENSMUST00000034562
GeneID	12955
KEGG	mmu:12955
UCSC	uc009pkl.1
CTD	1410
MGI	MGI:88516
eggNOG	NOG246790
HOGENOM	HOG000233954
HOVERGEN	HBG054766
InParanoid	P23927
KO	K09542
OMA	LTITAPM
OrthoDB	EOG7WHHBK
PhylomeDB	P23927
TreeFam	TF105049
ChiTaRS	Cryab
NextBio	282674
PRO	PR:P23927
Proteomes	UP000000589
Bgee	P23927
CleanEx	MM_CRYAB
ExpressionAtlas	P23927
Genevestigator	P23927
GO	GO:0032432 GO:0009986 GO:0043292 GO:0005829 GO:0070062 GO:0005794 GO:0015630 GO:0005739 GO:0005634 GO:0005886 GO:0030018 GO:0046872 GO:0042803 GO:0005212 GO:0007568 GO:0060561 GO:0043010 GO:0071480 GO:0002088 GO:0031109 GO:0007517 GO:0043066 GO:0030308 GO:0043154 GO:0010629 GO:0032387 GO:2000378 GO:0006457 GO:0051260 GO:0010941 GO:0032355 GO:0042542 GO:0001666 GO:0051403 GO:0007021
Gene3D	2.60.40.790
InterPro	IPR002068 IPR001436 IPR012273 IPR003090 IPR008978
PANTHER	PTHR11527:SF37
Pfam	PF00525 PF00011
PIRSF	PIRSF036514
PRINTS	PR00299
SUPFAM	SSF49764
PROSITE	PS01031

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:22442691^[1]	ECO:0000315			P		Figure 1E.	complete CACAO 4019
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02511	C		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02511	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02511	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905907	negative regulation of amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071480	cellular response to gamma radiation	PMID:23542032^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060561	apoptotic process involved in morphogenesis	PMID:16439475^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	F		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	PMID:14627610^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16439475^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:18191123^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12546709^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88515	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	PMID:17438522^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652177	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032463	negative regulation of protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
part_of	GO:0032432	actin filament bundle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032387	negative regulation of intracellular transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
part_of	GO:0031674	I band	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
part_of	GO:0031430	M band	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031109	microtubule polymerization or depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	P		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:14627610^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010941	regulation of cell death	PMID:23542032^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:17893660^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652177	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007517	muscle organ development	PMID:11687538^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1916503	P	results_in_development_of:(EMAPA:35578)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007021	tubulin complex assembly	PMID:16675842^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006457	protein folding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14627610^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18191123^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18191123^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2414	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:16439475^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:18191123^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652177	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02511	F		Seeded From UniProt	complete
involved_in	GO:1905907	negative regulation of amyloid fibril formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	C		Seeded From UniProt	complete
involved_in	GO:0032463	negative regulation of protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
involved_in	GO:0032387	negative regulation of intracellular transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
involved_in	GO:0010941	regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	C		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02511 ensembl:ENSP00000433560	F		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0032432	actin filament bundle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0031674	I band	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
part_of	GO:0031430	M band	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
involved_in	GO:0031109	microtubule polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
involved_in	GO:0010259	multicellular organism aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23928 ensembl:ENSRNOP00000055901	C		Seeded From UniProt	complete
enables	GO:0005212	structural constituent of eye lens	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003090	F		Seeded From UniProt	complete
enables	GO:0005212	structural constituent of eye lens	PMID:12546709^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005212	structural constituent of eye lens	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0273	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sreekumar, PG et al. (2012) Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS ONE 7 e33420 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Yamashita, A et al. (2013) Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. FEBS Lett. 587 1299-303 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Morozov, V & Wawrousek, EF (2006) Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development 133 813-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Koh, TJ & Escobedo, J (2004) Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Am. J. Physiol., Cell Physiol. 286 C713-22 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Yaung, J et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp. Eye Res. 86 355-65 PubMed GONUTS page
↑ ^7.0 ^7.1 Boyle, DL et al. (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3 3 PubMed GONUTS page
↑ Yaung, J et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol. Vis. 13 566-77 PubMed GONUTS page
↑ Bai, F et al. (2007) Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol. Vis. 13 1589-600 PubMed GONUTS page
↑ Brady, JP et al. (2001) AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest. Ophthalmol. Vis. Sci. 42 2924-34 PubMed GONUTS page
↑ Xi, JH et al. (2006) Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J. 20 846-57 PubMed GONUTS page

[PMID:22442691-1] Sreekumar, PG et al. (2012) Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS ONE 7 e33420 PubMed GONUTS page

[PMID:17634366-2] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:23542032-3] 3.0 ^3.1 Yamashita, A et al. (2013) Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. FEBS Lett. 587 1299-303 PubMed GONUTS page

[PMID:16439475-4] 4.0 ^4.1 ^4.2 Morozov, V & Wawrousek, EF (2006) Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development 133 813-21 PubMed GONUTS page

[PMID:14627610-5] 5.0 ^5.1 ^5.2 Koh, TJ & Escobedo, J (2004) Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Am. J. Physiol., Cell Physiol. 286 C713-22 PubMed GONUTS page

[PMID:18191123-6] 6.0 ^6.1 ^6.2 ^6.3 Yaung, J et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp. Eye Res. 86 355-65 PubMed GONUTS page

[PMID:12546709-7] 7.0 ^7.1 Boyle, DL et al. (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3 3 PubMed GONUTS page

[PMID:17438522-8] Yaung, J et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol. Vis. 13 566-77 PubMed GONUTS page

[PMID:17893660-9] Bai, F et al. (2007) Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol. Vis. 13 1589-600 PubMed GONUTS page

[PMID:11687538-10] Brady, JP et al. (2001) AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest. Ophthalmol. Vis. Sci. 42 2924-34 PubMed GONUTS page

[PMID:16675842-11] Xi, JH et al. (2006) Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J. 20 846-57 PubMed GONUTS page

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