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PMID:12546709
| Citation |
Boyle, DL, Takemoto, L, Brady, JP and Wawrousek, EF (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3:3 |
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| Abstract |
One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alpha A and alpha B are normally expressed at high levels. The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alpha A- and alpha B-crystallin genes (alpha A/BKO). |
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| Keywords |
Animals; Cataract/genetics; Cataract/pathology; Gene Deletion; Lens, Crystalline/ultrastructure; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Electron, Scanning; alpha-Crystallin A Chain/physiology; alpha-Crystallin B Chain/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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