GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17438522

From GONUTS
Jump to: navigation, search
Citation

Yaung, J, Jin, M, Barron, E, Spee, C, Wawrousek, EF, Kannan, R and Hinton, DR (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol. Vis. 13:566-77

Abstract

To investigate the susceptibility of retinal pigment epithelium (RPE) from alphaA (-/-) and alphaB (-/-) mice to oxidative stress, and the subcellular changes of alphaA and alphaB-crystallins under oxidative stress.

Links

PubMed PMC2652021

Keywords

Animals; Apoptosis; Caspase 3/metabolism; Cells, Cultured; Enzyme Activation; Humans; Hydrogen Peroxide/pharmacology; Intracellular Membranes/metabolism; Mice; Mice, Knockout; Mitochondria/metabolism; Oxidants/pharmacology; Oxidative Stress; Permeability; Pigment Epithelium of Eye/cytology; Pigment Epithelium of Eye/drug effects; Pigment Epithelium of Eye/metabolism; Pigment Epithelium of Eye/physiology; Tissue Distribution/drug effects; alpha-Crystallin A Chain/genetics; alpha-Crystallin A Chain/metabolism; alpha-Crystallin B Chain/genetics; alpha-Crystallin B Chain/metabolism; alpha-Crystallins/deficiency; alpha-Crystallins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CRYAA

acts_upstream_of_or_within

GO:0042542: response to hydrogen peroxide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

MOUSE:CRYAB

acts_upstream_of_or_within

GO:0042542: response to hydrogen peroxide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2652177

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.