Category:GO:1905907 ! negative regulation of amyloid fibril formation

name: negative regulation of amyloid fibril formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]
comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
synonym: "down regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "downregulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "inhibition of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of amyloid fibril formation" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of amyloid structure formation" RELATED [GOC:TermGenie]
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1905906 ! regulation of amyloid fibril formation
relationship: negatively_regulates: GO:1990000 ! amyloid fibril formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990000 ! amyloid fibril formation

AmiGO <GOterm>GO:1905907</GOterm>
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