HUMAN:APOE

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	APOE
Protein Name(s)	Apolipoprotein E Apo-E
External Links
UniProt	P02649
EMBL	M12529 K00396 M10065 AF050154 AF261279 AK314898 FJ525876 BC003557 AB035149
CCDS	CCDS12647.1
PIR	A92478
RefSeq	NP_000032.1 NP_001289617.1 NP_001289618.1 NP_001289619.1 NP_001289620.1
UniGene	Hs.654439
PDB	1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B
PDBsum	1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B
DisProt	DP00355
ProteinModelPortal	P02649
SMR	P02649
BioGrid	106845
DIP	DIP-1120N
IntAct	P02649
MINT	MINT-4999641
STRING	9606.ENSP00000252486
DrugBank	DB00062 DB00064
PhosphoSite	P02649
BioMuta	APOE
DMDM	114039
DOSAC-COBS-2DPAGE	P02649
SWISS-2DPAGE	P02649
MaxQB	P02649
PaxDb	P02649
PeptideAtlas	P02649
PRIDE	P02649
DNASU	348
Ensembl	ENST00000252486
GeneID	348
KEGG	hsa:348
UCSC	uc002pab.3
CTD	348
GeneCards	GC19P045408
HGNC	HGNC:613
HPA	CAB008363
MIM	104310 107741 143890 269600 611771
neXtProt	NX_P02649
Orphanet	238616 1648 406 412 329481 158029
PharmGKB	PA55
eggNOG	NOG44867
GeneTree	ENSGT00730000111315
HOGENOM	HOG000034006
HOVERGEN	HBG010582
InParanoid	P02649
KO	K04524
OMA	PLQERAQ
OrthoDB	EOG793B87
PhylomeDB	P02649
TreeFam	TF334458
Reactome	REACT_13621 REACT_163699 REACT_24968 REACT_6841
ChiTaRS	APOE
EvolutionaryTrace	P02649
GeneWiki	Apolipoprotein_E
GenomeRNAi	348
NextBio	1435
PMAP-CutDB	P02649
PRO	PR:P02649
Proteomes	UP000005640
Bgee	P02649
CleanEx	HS_APOE
ExpressionAtlas	P02649
Genevisible	P02649
GO	GO:0072562 GO:0042627 GO:0005737 GO:0030425 GO:0005769 GO:0071682 GO:0005783 GO:0070062 GO:0031012 GO:0005576 GO:0005615 GO:1903561 GO:0005794 GO:0034364 GO:0034363 GO:0034362 GO:0016020 GO:0043025 GO:0005634 GO:0005886 GO:0034361 GO:0016209 GO:0001540 GO:0015485 GO:0017127 GO:0008201 GO:0042802 GO:0008289 GO:0005319 GO:0071813 GO:0050750 GO:0046911 GO:0060228 GO:0005543 GO:0042803 GO:0048156 GO:0070326 GO:0097113 GO:0048844 GO:0006874 GO:0019934 GO:0006695 GO:0006707 GO:0033344 GO:0042632 GO:0008203 GO:0034382 GO:0007010 GO:0055089 GO:0007186 GO:0034380 GO:0034384 GO:0034375 GO:0046907 GO:0042158 GO:0042159 GO:0042157 GO:0015909 GO:0034374 GO:0051651 GO:0097114 GO:1902430 GO:0030195 GO:0043537 GO:0045541 GO:0090370 GO:0061000 GO:1902951 GO:0001937 GO:0050728 GO:0051055 GO:1903001 GO:0043407 GO:0043524 GO:1901215 GO:1902999 GO:0010544 GO:1901627 GO:1901630 GO:0031102 GO:0007263 GO:0033700 GO:0007603 GO:0044794 GO:1902004 GO:0030828 GO:0010875 GO:0010873 GO:0060999 GO:1902952 GO:0046889 GO:1903002 GO:0032805 GO:0051044 GO:1902998 GO:1901216 GO:0051000 GO:1902995 GO:1901628 GO:1901631 GO:0017038 GO:0006898 GO:0030516 GO:1900221 GO:0032489 GO:0010468 GO:1901214 GO:0048168 GO:1902947 GO:0002021 GO:0000302 GO:0001523 GO:0043691 GO:0044281 GO:0007271 GO:0019433 GO:0006641 GO:0042311 GO:0034447 GO:0034372 GO:0019068
InterPro	IPR000074
Pfam	PF01442

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0034364	high-density lipoprotein particle	PMID:14754908^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:14754908^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	PMID:23620513^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:23620513^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:9488694^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:9488694^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034447	very-low-density lipoprotein particle clearance	PMID:2762297^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08226	P	regulates_expression_of:(ENSEMBL:ENSG00000100600) occurs_in:(UBERON:0001637) regulates_o_occurs_in:(UBERON:0001637)	Seeded From UniProt	complete
involved_in	GO:0071830	triglyceride-rich lipoprotein particle clearance	PMID:23676495^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:23676495^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:8939961^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8340399^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8340399^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	PMID:27044754^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10636)\|regulates_o_occurs_in(CL:0002321)	Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	PMID:2280190^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:2280190^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:2280190^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:2280190^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:7635945^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:7635945^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:1530612^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:28111074^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	PMID:28111074^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:28111074^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:8071364^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:8071364^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010596	negative regulation of endothelial cell migration	PMID:23142051^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:27477018^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZC2	F	happens_during:(GO:0006497)	Seeded From UniProt	complete
involved_in	GO:0071831	intermediate-density lipoprotein particle clearance	PMID:1917954^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034382	chylomicron remnant clearance	PMID:1911868^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032462	regulation of protein homooligomerization	PMID:25207746^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05067:PRO_0000000093)\|has_regulation_target:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:25207746^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:25207746^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
involved_in	GO:1905906	regulation of amyloid fibril formation	PMID:25207746^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:22138302^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:22138302^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092 UniProtKB:P05067:PRO_0000000093	F	occurs_in:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:22138302^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:22138302^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	PMID:22138302^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:22138302^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042982	amyloid precursor protein metabolic process	PMID:21593558^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	PMID:16273551^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08226	C	part_of:(UBERON:0000955) part_of:(UBERON:0000913)	Seeded From UniProt	complete
involved_in	GO:0051246	regulation of protein metabolic process	PMID:24412220^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P01130 UniProtKB:P35951	P	has_regulation_target:(UniProtKB:P02649) regulates_o_occurs_in:(UBERON:0001969)\|has_regulation_target(UniProtKB:P02649) regulates_o_occurs_in:(UBERON:0000956)\|has_regulation_target(UniProtKB:P02649) regulates_o_occurs_in:(UBERON:0001876)\|has_regulation_target(UniProtKB:P02649) regulates_o_occurs_in:(UBERON:0002421)\|has_regulation_target(UniProtKB:P02649) regulates_o_occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:2000822	regulation of behavioral fear response	PMID:24412220^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0001876)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:9003062^[23]	ECO:0000353	physical interaction evidence used in manual assertion	CHEBI:64645	F		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	PMID:8300609^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(GO:0034361)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[25]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08226	C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:25015123^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	has_regulation_target:(UniProtKB:P01130) regulates_o_occurs_in:(CL:2000044)\|has_regulation_target(UniProtKB:Q07954) regulates_o_occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0010877	lipid transport involved in lipid storage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0061771	response to caloric restriction	PMID:24412220^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P35951	P		Seeded From UniProt	complete
involved_in	GO:0061771	response to caloric restriction	PMID:24412220^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P01130	P		Seeded From UniProt	complete
involved_in	GO:0090181	regulation of cholesterol metabolic process	PMID:24412220^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P35951	P	regulates_o_occurs_in:(UBERON:0001969) part_of:(GO:0061771)	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:24412220^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P01130	P	regulates_o_occurs_in:(UBERON:0001969) part_of:(GO:0061771)	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:24412220^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P01130 UniProtKB:P35951	P		Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	PMID:24412220^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:9211985^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F	occurs_in:(GO:0034362)\|occurs_in:(GO:0034363)\|occurs_in:(GO:0034361)	Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:20005821^[28]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990777	lipoprotein particle	PMID:22138302^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[29]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:7592957^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1905890)	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:23845000^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001997)	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08226	P	occurs_in:(UBERON:0001997)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:8089103^[32]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(CHEBI:64646)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8089103^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:8089103^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1905890	regulation of cellular response to very-low-density lipoprotein particle stimulus	PMID:7592957^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:7592957^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1905890)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:16805831^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:16805831^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00755	P	occurs_in:(GO:0005576)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:16805831^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032269	negative regulation of cellular protein metabolic process	PMID:16805831^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00755	P	has_regulation_target:(UniProtKB:Q9WU82) regulates_o_occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:16805831^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00755	P	has_agent:(GO:0034361)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:16805831^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00755 UniProtKB:O00755,UniProtKB:O54908 UniProtKB:O00755,UniProtKB:O75197 UniProtKB:O00755,UniProtKB:O75581	P		Seeded From UniProt	complete
involved_in	GO:1905860	positive regulation of heparan sulfate proteoglycan binding	PMID:8300609^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(GO:0034361)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9211985^[27]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0034364)\|occurs_in:(GO:0034362)\|occurs_in:(GO:0034363)\|occurs_in:(GO:0034361)	Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	PMID:9211985^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	PMID:7683668^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(GO:0034361)	Seeded From UniProt	complete
involved_in	GO:1905855	positive regulation of heparan sulfate binding	PMID:7683668^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(GO:0034360) regulates_o_occurs_in:(GO:0031240)	Seeded From UniProt	complete
involved_in	GO:1905855	positive regulation of heparan sulfate binding	PMID:7683668^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(GO:0034361) regulates_o_occurs_in:(GO:0031240)	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:9211985^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:9211985^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:9211985^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:25122793^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:25122793^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044794	positive regulation by host of viral process	PMID:25122793^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q81449)	Seeded From UniProt	complete
involved_in	GO:0019068	virion assembly	PMID:25122793^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[36]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[37]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:24769233^[38]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[39]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903002	positive regulation of lipid transport across blood-brain barrier	PMID:24345162^[40]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:28125)	Seeded From UniProt	complete
involved_in	GO:1902995	positive regulation of phospholipid efflux	PMID:12042316^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:1902952	positive regulation of dendritic spine maintenance	PMID:24328732^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:24154541^[43]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1901630	negative regulation of presynaptic membrane organization	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1901628	positive regulation of postsynaptic membrane organization	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:24446231^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:24328732^[42]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0060996)	Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:24328732^[42]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0060996)	Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:24328732^[42]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0048666)	Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	PMID:24345162^[40]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:15843)\|has_input:(CHEBI:26208)\|has_input:(CHEBI:28125)	Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:12042316^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0017038	protein import	PMID:24446231^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0015909	long-chain fatty acid transport	PMID:24345162^[40]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:28125)	Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:12042316^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[46]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[47]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[48]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[49]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[50]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
enables	GO:0070326	very-low-density lipoprotein particle receptor binding	PMID:12950167^[51]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14114	F		Seeded From UniProt	complete
enables	GO:0070326	very-low-density lipoprotein particle receptor binding	PMID:1384047^[52]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:15654758^[53]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:15950758^[54]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:8995232^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:17326667^[56]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92673	F		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:210175^[57]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:8995232^[55]	ECO:0000305	curator inference used in manual assertion	GO:0051000	P		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:7566652^[58]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10636	F		Seeded From UniProt	complete
enables	GO:0046911	metal chelating activity	PMID:9685360^[59]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045541	negative regulation of cholesterol biosynthetic process	PMID:1917954^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:8127890^[60]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:9685360^[59]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:9685360^[59]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:8083695^[61]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8245722^[62]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:4066713^[63]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:9649566^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:16935699^[65]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:8245722^[62]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034447	very-low-density lipoprotein particle clearance	PMID:9649566^[64]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034447	very-low-density lipoprotein particle clearance	PMID:1917954^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034384	high-density lipoprotein particle clearance	PMID:210175^[57]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034382	chylomicron remnant clearance	PMID:7175379^[66]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:17305370^[67]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:12401887^[68]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:12401887^[68]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:15654758^[53]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:210174^[69]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:17336988^[70]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	PMID:8245722^[62]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:17154273^[71]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:8245722^[62]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:11162594^[72]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:11162594^[72]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:16443932^[73]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	PMID:15950758^[54]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	PMID:16443932^[73]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:8083695^[61]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030195	negative regulation of blood coagulation	PMID:8995232^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	PMID:8995232^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	PMID:9685360^[59]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:12401887^[68]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:14754908^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:15654758^[53]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010544	negative regulation of platelet activation	PMID:8995232^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:3771793^[74]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:9649566^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:2745454^[75]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:8995232^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:16443932^[73]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:1917954^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	PMID:3771793^[74]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	PMID:9649566^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8083695^[61]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20551380^[76]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:4066713^[63]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005319	lipid transporter activity	PMID:17305370^[67]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:9685360^[59]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:4066713^[63]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:11305869^[77]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	PMID:11743999^[78]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22637583^[79]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22637583^[79]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22637583^[79]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	PMID:22637583^[79]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	PMID:22637583^[79]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	PMID:22637583^[79]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	P		Seeded From UniProt	complete
enables	GO:0070326	very-low-density lipoprotein particle receptor binding	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	F		Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	F		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	P		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	F		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02649	P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 RGD:2138	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2132 RGD:2138 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	C		Seeded From UniProt	complete
involved_in	GO:0042159	lipoprotein catabolic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439008	P		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 RGD:2138	P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649	P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2130 RGD:2138 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 RGD:2138 UniProtKB:P02649	C		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0032374	regulation of cholesterol transport	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:Q6Q788	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 MGI:MGI:88057 PANTHER:PTN000439006 RGD:2130 UniProtKB:P02647 UniProtKB:P06727	F		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647	F		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439008	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 PANTHER:PTN000439006	P		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2138 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:Q6Q788	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[80]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 RGD:2138 UniProtKB:P02649	F		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016209	P		Seeded From UniProt	complete
involved_in	GO:1905907	negative regulation of amyloid fibril formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:1900223	positive regulation of amyloid-beta clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	C		Seeded From UniProt	complete
involved_in	GO:0097006	regulation of plasma lipoprotein particle levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0090209	negative regulation of triglyceride metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0071830	triglyceride-rich lipoprotein particle clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	F		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	F		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0051651	maintenance of location in cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	F		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0042159	lipoprotein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0034374	low-density lipoprotein particle remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	C		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	F		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0010877	lipid transport involved in lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	C		Seeded From UniProt	complete
involved_in	GO:0002021	response to dietary excess	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08226 ensembl:ENSMUSP00000133302	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	F		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	P		Seeded From UniProt	complete
involved_in	GO:1903001	negative regulation of lipid transport across blood-brain barrier	PMID:24345162^[40]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:28125)	Seeded From UniProt	complete
involved_in	GO:1902999	negative regulation of phospholipid efflux	PMID:12042316^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:1902998	positive regulation of neurofibrillary tangle assembly	PMID:24154541^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	PMID:24328732^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902947	regulation of tau-protein kinase activity	PMID:24154541^[43]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:24154541^[43]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1901627	negative regulation of postsynaptic membrane organization	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1901214	regulation of neuron death	PMID:24154541^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090370	negative regulation of cholesterol efflux	PMID:12042316^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0061000	negative regulation of dendritic spine development	PMID:24328732^[42]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0048666)	Seeded From UniProt	complete
involved_in	GO:0051055	negative regulation of lipid biosynthetic process	PMID:12042316^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901631	positive regulation of presynaptic membrane organization	PMID:24259049^[44]	ECO:0000314	direct assay evidence used in manual assertion		P	during:(GO:0034205)	Seeded From UniProt	complete
involved_in	GO:1905908	positive regulation of amyloid fibril formation	PMID:20005821^[28] PMID:9228033^[81]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034365	discoidal high-density lipoprotein particle	PMID:22383525^[82]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	produced_by:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:22138302^[19] Reactome:R-HSA-3000480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(GO:1990777)	Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:22138302^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_input:(GO:1990777)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:22988876^[83]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	PMID:9622609^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046907	intracellular transport	PMID:9622609^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	PMID:9622609^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	PMID:9622609^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:9622609^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9622609^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071682	endocytic vesicle lumen	Reactome:R-HSA-2507854	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034382	chylomicron remnant clearance	Reactome:R-HSA-8964026	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034378	chylomicron assembly	Reactome:R-HSA-8963888	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	Reactome:R-HSA-8964058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	Reactome:R-HSA-8963901	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030669	clathrin-coated endocytic vesicle membrane	Reactome:R-HSA-174706	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	Reactome:R-HSA-8864260	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-174706 Reactome:R-HSA-174657	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	Reactome:R-HSA-2429643 Reactome:R-HSA-2404140 Reactome:R-HSA-2404131	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8869590 Reactome:R-HSA-266303 Reactome:R-HSA-2507854 Reactome:R-HSA-2423785 Reactome:R-HSA-2404131 Reactome:R-HSA-2395784 Reactome:R-HSA-2395768 Reactome:R-HSA-174757 Reactome:R-HSA-174739 Reactome:R-HSA-174690 Reactome:R-HSA-174660 Reactome:R-HSA-174657	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0162	C		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0850	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0345	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Krimbou, L et al. (2004) Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J. Lipid Res. 45 839-48 PubMed GONUTS page
↑ ^2.0 ^2.1 Verghese, PB et al. (2013) ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc. Natl. Acad. Sci. U.S.A. 110 E1807-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Burgess, JW et al. (1998) The HepG2 extracellular matrix contains separate heparinase- and lipid-releasable pools of ApoE. Implications for hepatic lipoprotein metabolism. J. Biol. Chem. 273 5645-54 PubMed GONUTS page
↑ Kowal, RC et al. (1989) Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc. Natl. Acad. Sci. U.S.A. 86 5810-4 PubMed GONUTS page
↑ ^5.0 ^5.1 Gonzales, JC et al. (2013) Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J. Clin. Invest. 123 2742-51 PubMed GONUTS page
↑ Fagan, AM et al. (1996) Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271 30121-5 PubMed GONUTS page
↑ ^7.0 ^7.1 Westerlund, JA & Weisgraber, KH (1993) Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. J. Biol. Chem. 268 15745-50 PubMed GONUTS page
↑ Yan, X et al. (2016) FRMD4A-cytohesin signaling modulates the cellular release of tau. J. Cell. Sci. 129 2003-15 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Weisgraber, KH (1990) Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. J. Lipid Res. 31 1503-11 PubMed GONUTS page
↑ ^10.0 ^10.1 Mann, WA et al. (1995) Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu). J. Clin. Invest. 96 1100-7 PubMed GONUTS page
↑ Dong, LM et al. (1992) Site-directed mutagenesis of an apolipoprotein E mutant, apo E5(Glu3----Lys) and its binding to low density lipoprotein receptors. Biochem. Biophys. Res. Commun. 187 1180-6 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Huang, YA et al. (2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. Cell 168 427-441.e21 PubMed GONUTS page
↑ ^13.0 ^13.1 Dong, LM et al. (1994) Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269 22358-65 PubMed GONUTS page
↑ Pencheva, N et al. (2012) Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 151 1068-82 PubMed GONUTS page
↑ Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Sehayek, E & Eisenberg, S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266 18259-67 PubMed GONUTS page
↑ Arnon, R et al. (1991) Effects of exogenous apo E-3 and of cholesterol-enriched meals on the cellular metabolism of human chylomicrons and their remnants. Biochim. Biophys. Acta 1085 336-42 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Garai, K et al. (2014) The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation. Biochemistry 53 6323-31 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 LaDu, MJ et al. (2012) Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift. Biochim. Biophys. Acta 1821 295-302 PubMed GONUTS page
↑ Hopkins, PC et al. (2011) The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β. J. Alzheimers Dis. 26 239-53 PubMed GONUTS page
↑ Yun, SH et al. (2005) Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. J. Neurosci. Res. 82 771-7 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 Johnson, LA et al. (2014) Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. Neurobiol. Dis. 64 150-62 PubMed GONUTS page
↑ Yang, DS et al. (1997) Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma. J. Neurochem. 68 721-5 PubMed GONUTS page
↑ ^24.0 ^24.1 Ji, ZS et al. (1994) Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J. Biol. Chem. 269 2764-72 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Bachmeier, C et al. (2014) Apolipoprotein E isoform-specific effects on lipoprotein receptor processing. Neuromolecular Med. 16 686-96 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 LaDu, MJ et al. (1997) Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. J. Neurosci. Res. 49 9-18 PubMed GONUTS page
↑ ^28.0 ^28.1 Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Bellosta, S et al. (1995) Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J. Biol. Chem. 270 27063-71 PubMed GONUTS page
↑ Hussain, A et al. (2013) Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. J. Biomed. Sci. 20 49 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 LaDu, MJ et al. (1994) Isoform-specific binding of apolipoprotein E to beta-amyloid. J. Biol. Chem. 269 23403-6 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Ji, ZS et al. (1993) Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J. Biol. Chem. 268 10160-7 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 Lee, JY et al. (2014) Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J. Virol. 88 12422-37 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 Vandal, M et al. (2014) Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. J. Neurochem. 129 516-26 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 ^41.3 ^41.4 ^41.5 Gong, JS et al. (2002) Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J. Biol. Chem. 277 29919-26 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 ^42.4 ^42.5 Nwabuisi-Heath, E et al. (2014) ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro. ASN Neuro 6 e00134 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 ^43.3 ^43.4 Zhao, W et al. (2014) Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model. Hum. Mol. Genet. 23 1365-75 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 ^44.4 ^44.5 ^44.6 ^44.7 Hudry, E et al. (2013) Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Sci Transl Med 5 212ra161 PubMed GONUTS page
↑ ^45.0 ^45.1 Mulder, SD et al. (2014) Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. Glia 62 493-503 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Li, X et al. (2003) Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. Biochemistry 42 10406-17 PubMed GONUTS page
↑ Takahashi, S et al. (1992) Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc. Natl. Acad. Sci. U.S.A. 89 9252-6 PubMed GONUTS page
↑ ^53.0 ^53.1 ^53.2 Zhao, Y et al. (2005) Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry 44 1013-25 PubMed GONUTS page
↑ ^54.0 ^54.1 Hoe, HS & Rebeck, GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137 31-9 PubMed GONUTS page
↑ ^55.0 ^55.1 ^55.2 ^55.3 ^55.4 ^55.5 Riddell, DR et al. (1997) Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease. J. Biol. Chem. 272 89-95 PubMed GONUTS page
↑ Nilsson, SK et al. (2007) Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46 3896-904 PubMed GONUTS page
↑ ^57.0 ^57.1 Innerarity, TL et al. (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex. J. Biol. Chem. 253 6289-95 PubMed GONUTS page
↑ Huang, DY et al. (1995) ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci. Lett. 192 209-12 PubMed GONUTS page
↑ ^59.0 ^59.1 ^59.2 ^59.3 ^59.4 Ishigami, M et al. (1998) Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. J. Biol. Chem. 273 20156-61 PubMed GONUTS page
↑ Huang, Y et al. (1994) A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proc. Natl. Acad. Sci. U.S.A. 91 1834-8 PubMed GONUTS page
↑ ^61.0 ^61.1 ^61.2 Han, SH et al. (1994) Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. J. Neuropathol. Exp. Neurol. 53 535-44 PubMed GONUTS page
↑ ^62.0 ^62.1 ^62.2 ^62.3 Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page
↑ ^63.0 ^63.1 ^63.2 Yokoyama, S et al. (1985) Behavior of human apolipoprotein E in aqueous solutions and at interfaces. J. Biol. Chem. 260 16375-82 PubMed GONUTS page
↑ ^64.0 ^64.1 ^64.2 ^64.3 Sullivan, PM et al. (1998) Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J. Clin. Invest. 102 130-5 PubMed GONUTS page
↑ Jackson, KG et al. (2006) Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids. Nutr Metab Cardiovasc Dis 16 405-17 PubMed GONUTS page
↑ Breslow, JL et al. (1982) Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. J. Lipid Res. 23 1224-35 PubMed GONUTS page
↑ ^67.0 ^67.1 Vedhachalam, C et al. (2007) The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry 46 2583-93 PubMed GONUTS page
↑ ^68.0 ^68.1 ^68.2 Hopkins, PC et al. (2002) Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J. Lipid Res. 43 1881-9 PubMed GONUTS page
↑ Weisgraber, KH & Mahley, RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253 6281-8 PubMed GONUTS page
↑ Meyer, BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195 e28-34 PubMed GONUTS page
↑ Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page
↑ ^72.0 ^72.1 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page
↑ ^73.0 ^73.1 ^73.2 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page
↑ ^74.0 ^74.1 Schaefer, EJ et al. (1986) Familial apolipoprotein E deficiency. J. Clin. Invest. 78 1206-19 PubMed GONUTS page
↑ Fielding, PE et al. (1989) Apolipoprotein E mediates binding of normal very low density lipoprotein to heparin but is not required for high affinity receptor binding. J. Biol. Chem. 264 12462-6 PubMed GONUTS page
↑ Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ Cho, HS et al. (2001) Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation. J. Neuropathol. Exp. Neurol. 60 342-9 PubMed GONUTS page
↑ Lauderback, CM et al. (2002) Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner. Brain Res. 924 90-7 PubMed GONUTS page
↑ ^79.0 ^79.1 ^79.2 ^79.3 ^79.4 ^79.5 Koffie, RM et al. (2012) Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain 135 2155-68 PubMed GONUTS page
↑ ^80.00 ^80.01 ^80.02 ^80.03 ^80.04 ^80.05 ^80.06 ^80.07 ^80.08 ^80.09 ^80.10 ^80.11 ^80.12 ^80.13 ^80.14 ^80.15 ^80.16 ^80.17 ^80.18 ^80.19 ^80.20 ^80.21 ^80.22 ^80.23 ^80.24 ^80.25 ^80.26 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hammad, SM et al. (1997) Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J. Biol. Chem. 272 18644-9 PubMed GONUTS page
↑ Basak, JM et al. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. J. Biol. Chem. 287 13959-71 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page
↑ ^84.0 ^84.1 ^84.2 ^84.3 ^84.4 ^84.5 Beffert, U et al. (1998) The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease. Brain Res. Brain Res. Rev. 27 119-42 PubMed GONUTS page

[PMID:14754908-1] 1.0 ^1.1 ^1.2 Krimbou, L et al. (2004) Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J. Lipid Res. 45 839-48 PubMed GONUTS page

[PMID:23620513-2] 2.0 ^2.1 Verghese, PB et al. (2013) ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc. Natl. Acad. Sci. U.S.A. 110 E1807-16 PubMed GONUTS page

[PMID:9488694-3] 3.0 ^3.1 Burgess, JW et al. (1998) The HepG2 extracellular matrix contains separate heparinase- and lipid-releasable pools of ApoE. Implications for hepatic lipoprotein metabolism. J. Biol. Chem. 273 5645-54 PubMed GONUTS page

[PMID:2762297-4] Kowal, RC et al. (1989) Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc. Natl. Acad. Sci. U.S.A. 86 5810-4 PubMed GONUTS page

[PMID:23676495-5] 5.0 ^5.1 Gonzales, JC et al. (2013) Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J. Clin. Invest. 123 2742-51 PubMed GONUTS page

[PMID:8939961-6] Fagan, AM et al. (1996) Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271 30121-5 PubMed GONUTS page

[PMID:8340399-7] 7.0 ^7.1 Westerlund, JA & Weisgraber, KH (1993) Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. J. Biol. Chem. 268 15745-50 PubMed GONUTS page

[PMID:27044754-8] Yan, X et al. (2016) FRMD4A-cytohesin signaling modulates the cellular release of tau. J. Cell. Sci. 129 2003-15 PubMed GONUTS page

[PMID:2280190-9] 9.0 ^9.1 ^9.2 ^9.3 Weisgraber, KH (1990) Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. J. Lipid Res. 31 1503-11 PubMed GONUTS page

[PMID:7635945-10] 10.0 ^10.1 Mann, WA et al. (1995) Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu). J. Clin. Invest. 96 1100-7 PubMed GONUTS page

[PMID:1530612-11] Dong, LM et al. (1992) Site-directed mutagenesis of an apolipoprotein E mutant, apo E5(Glu3----Lys) and its binding to low density lipoprotein receptors. Biochem. Biophys. Res. Commun. 187 1180-6 PubMed GONUTS page

[PMID:28111074-12] 12.0 ^12.1 ^12.2 Huang, YA et al. (2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. Cell 168 427-441.e21 PubMed GONUTS page

[PMID:8071364-13] 13.0 ^13.1 Dong, LM et al. (1994) Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269 22358-65 PubMed GONUTS page

[PMID:23142051-14] Pencheva, N et al. (2012) Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 151 1068-82 PubMed GONUTS page

[PMID:27477018-15] Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page

[PMID:1917954-16] 16.0 ^16.1 ^16.2 ^16.3 Sehayek, E & Eisenberg, S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266 18259-67 PubMed GONUTS page

[PMID:1911868-17] Arnon, R et al. (1991) Effects of exogenous apo E-3 and of cholesterol-enriched meals on the cellular metabolism of human chylomicrons and their remnants. Biochim. Biophys. Acta 1085 336-42 PubMed GONUTS page

[PMID:25207746-18] 18.0 ^18.1 ^18.2 ^18.3 Garai, K et al. (2014) The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation. Biochemistry 53 6323-31 PubMed GONUTS page

[PMID:22138302-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 LaDu, MJ et al. (2012) Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift. Biochim. Biophys. Acta 1821 295-302 PubMed GONUTS page

[PMID:21593558-20] Hopkins, PC et al. (2011) The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β. J. Alzheimers Dis. 26 239-53 PubMed GONUTS page

[PMID:16273551-21] Yun, SH et al. (2005) Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. J. Neurosci. Res. 82 771-7 PubMed GONUTS page

[PMID:24412220-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 Johnson, LA et al. (2014) Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. Neurobiol. Dis. 64 150-62 PubMed GONUTS page

[PMID:9003062-23] Yang, DS et al. (1997) Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma. J. Neurochem. 68 721-5 PubMed GONUTS page

[PMID:8300609-24] 24.0 ^24.1 Ji, ZS et al. (1994) Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J. Biol. Chem. 269 2764-72 PubMed GONUTS page

[PMID:27068509-25] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:25015123-26] Bachmeier, C et al. (2014) Apolipoprotein E isoform-specific effects on lipoprotein receptor processing. Neuromolecular Med. 16 686-96 PubMed GONUTS page

[PMID:9211985-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 LaDu, MJ et al. (1997) Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. J. Neurosci. Res. 49 9-18 PubMed GONUTS page

[PMID:20005821-28] 28.0 ^28.1 Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page

[PMID:27559042-29] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:7592957-30] 30.0 ^30.1 ^30.2 Bellosta, S et al. (1995) Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J. Biol. Chem. 270 27063-71 PubMed GONUTS page

[PMID:23845000-31] Hussain, A et al. (2013) Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. J. Biomed. Sci. 20 49 PubMed GONUTS page

[PMID:8089103-32] 32.0 ^32.1 ^32.2 LaDu, MJ et al. (1994) Isoform-specific binding of apolipoprotein E to beta-amyloid. J. Biol. Chem. 269 23403-6 PubMed GONUTS page

[PMID:16805831-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page

[PMID:7683668-34] 34.0 ^34.1 ^34.2 Ji, ZS et al. (1993) Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J. Biol. Chem. 268 10160-7 PubMed GONUTS page

[PMID:25122793-35] 35.0 ^35.1 ^35.2 ^35.3 Lee, JY et al. (2014) Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J. Virol. 88 12422-37 PubMed GONUTS page

[PMID:23533145-36] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:23658023-37] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:24769233-38] Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page

[PMID:19946888-39] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:24345162-40] 40.0 ^40.1 ^40.2 ^40.3 Vandal, M et al. (2014) Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. J. Neurochem. 129 516-26 PubMed GONUTS page

[PMID:12042316-41] 41.0 ^41.1 ^41.2 ^41.3 ^41.4 ^41.5 Gong, JS et al. (2002) Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J. Biol. Chem. 277 29919-26 PubMed GONUTS page

[PMID:24328732-42] 42.0 ^42.1 ^42.2 ^42.3 ^42.4 ^42.5 Nwabuisi-Heath, E et al. (2014) ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro. ASN Neuro 6 e00134 PubMed GONUTS page

[PMID:24154541-43] 43.0 ^43.1 ^43.2 ^43.3 ^43.4 Zhao, W et al. (2014) Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model. Hum. Mol. Genet. 23 1365-75 PubMed GONUTS page

[PMID:24259049-44] 44.0 ^44.1 ^44.2 ^44.3 ^44.4 ^44.5 ^44.6 ^44.7 Hudry, E et al. (2013) Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Sci Transl Med 5 212ra161 PubMed GONUTS page

[PMID:24446231-45] 45.0 ^45.1 Mulder, SD et al. (2014) Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. Glia 62 493-503 PubMed GONUTS page

[PMID:22516433-46] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:19056867-47] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-48] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21630459-49] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:16502470-50] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:12950167-51] Li, X et al. (2003) Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. Biochemistry 42 10406-17 PubMed GONUTS page

[PMID:1384047-52] Takahashi, S et al. (1992) Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc. Natl. Acad. Sci. U.S.A. 89 9252-6 PubMed GONUTS page

[PMID:15654758-53] 53.0 ^53.1 ^53.2 Zhao, Y et al. (2005) Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry 44 1013-25 PubMed GONUTS page

[PMID:15950758-54] 54.0 ^54.1 Hoe, HS & Rebeck, GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137 31-9 PubMed GONUTS page

[PMID:8995232-55] 55.0 ^55.1 ^55.2 ^55.3 ^55.4 ^55.5 Riddell, DR et al. (1997) Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease. J. Biol. Chem. 272 89-95 PubMed GONUTS page

[PMID:17326667-56] Nilsson, SK et al. (2007) Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46 3896-904 PubMed GONUTS page

[PMID:210175-57] 57.0 ^57.1 Innerarity, TL et al. (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex. J. Biol. Chem. 253 6289-95 PubMed GONUTS page

[PMID:7566652-58] Huang, DY et al. (1995) ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci. Lett. 192 209-12 PubMed GONUTS page

[PMID:9685360-59] 59.0 ^59.1 ^59.2 ^59.3 ^59.4 Ishigami, M et al. (1998) Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. J. Biol. Chem. 273 20156-61 PubMed GONUTS page

[PMID:8127890-60] Huang, Y et al. (1994) A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proc. Natl. Acad. Sci. U.S.A. 91 1834-8 PubMed GONUTS page

[PMID:8083695-61] 61.0 ^61.1 ^61.2 Han, SH et al. (1994) Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. J. Neuropathol. Exp. Neurol. 53 535-44 PubMed GONUTS page

[PMID:8245722-62] 62.0 ^62.1 ^62.2 ^62.3 Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page

[PMID:4066713-63] 63.0 ^63.1 ^63.2 Yokoyama, S et al. (1985) Behavior of human apolipoprotein E in aqueous solutions and at interfaces. J. Biol. Chem. 260 16375-82 PubMed GONUTS page

[PMID:9649566-64] 64.0 ^64.1 ^64.2 ^64.3 Sullivan, PM et al. (1998) Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J. Clin. Invest. 102 130-5 PubMed GONUTS page

[PMID:16935699-65] Jackson, KG et al. (2006) Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids. Nutr Metab Cardiovasc Dis 16 405-17 PubMed GONUTS page

[PMID:7175379-66] Breslow, JL et al. (1982) Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. J. Lipid Res. 23 1224-35 PubMed GONUTS page

[PMID:17305370-67] 67.0 ^67.1 Vedhachalam, C et al. (2007) The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry 46 2583-93 PubMed GONUTS page

[PMID:12401887-68] 68.0 ^68.1 ^68.2 Hopkins, PC et al. (2002) Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J. Lipid Res. 43 1881-9 PubMed GONUTS page

[PMID:210174-69] Weisgraber, KH & Mahley, RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253 6281-8 PubMed GONUTS page

[PMID:17336988-70] Meyer, BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195 e28-34 PubMed GONUTS page

[PMID:17154273-71] Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page

[PMID:11162594-72] 72.0 ^72.1 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page

[PMID:16443932-73] 73.0 ^73.1 ^73.2 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page

[PMID:3771793-74] 74.0 ^74.1 Schaefer, EJ et al. (1986) Familial apolipoprotein E deficiency. J. Clin. Invest. 78 1206-19 PubMed GONUTS page

[PMID:2745454-75] Fielding, PE et al. (1989) Apolipoprotein E mediates binding of normal very low density lipoprotein to heparin but is not required for high affinity receptor binding. J. Biol. Chem. 264 12462-6 PubMed GONUTS page

[PMID:20551380-76] Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:11305869-77] Cho, HS et al. (2001) Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation. J. Neuropathol. Exp. Neurol. 60 342-9 PubMed GONUTS page

[PMID:11743999-78] Lauderback, CM et al. (2002) Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner. Brain Res. 924 90-7 PubMed GONUTS page

[PMID:22637583-79] 79.0 ^79.1 ^79.2 ^79.3 ^79.4 ^79.5 Koffie, RM et al. (2012) Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain 135 2155-68 PubMed GONUTS page

[PMID:21873635-80] 80.00 ^80.01 ^80.02 ^80.03 ^80.04 ^80.05 ^80.06 ^80.07 ^80.08 ^80.09 ^80.10 ^80.11 ^80.12 ^80.13 ^80.14 ^80.15 ^80.16 ^80.17 ^80.18 ^80.19 ^80.20 ^80.21 ^80.22 ^80.23 ^80.24 ^80.25 ^80.26 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9228033-81] Hammad, SM et al. (1997) Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J. Biol. Chem. 272 18644-9 PubMed GONUTS page

[PMID:22383525-82] Basak, JM et al. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. J. Biol. Chem. 287 13959-71 PubMed GONUTS page

[PMID:22988876-83] Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:9622609-84] 84.0 ^84.1 ^84.2 ^84.3 ^84.4 ^84.5 Beffert, U et al. (1998) The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease. Brain Res. Brain Res. Rev. 27 119-42 PubMed GONUTS page

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