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PMID:23845000

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Citation

Hussain, A, Luong, M, Pooley, A and Nathan, BP (2013) Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. J. Biomed. Sci. 20:49

Abstract

The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

Links

PubMed PMC3717083 Online version:10.1186/1423-0127-20-49

Keywords

Animals; Apolipoprotein E2/metabolism; Apolipoprotein E3/metabolism; Apolipoprotein E4/metabolism; Apolipoproteins E/metabolism; Cell Line; Humans; Mice; Mice, Knockout; Neurites/metabolism; Olfactory Mucosa/metabolism; Olfactory Mucosa/ultrastructure; Protein Isoforms/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:LRP6

involved_in

GO:0010976: positive regulation of neuron projection development

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:P02649

P

  • occurs_in:(UBERON:0001997)

Seeded From UniProt

complete

HUMAN:APOE

involved_in

GO:0010976: positive regulation of neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0001997)

Seeded From UniProt

complete

MOUSE:APOE

involved_in

GO:0010976: positive regulation of neuron projection development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0001997)

Seeded From UniProt

complete

HUMAN:APOE

involved_in

GO:0010976: positive regulation of neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0001997)

Seeded From UniProt

complete

Notes

See also

References

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