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PMID:23845000
| Citation |
Hussain, A, Luong, M, Pooley, A and Nathan, BP (2013) Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. J. Biomed. Sci. 20:49 |
|---|---|
| Abstract |
The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE). |
| Links |
PubMed PMC3717083 Online version:10.1186/1423-0127-20-49 |
| Keywords |
Animals; Apolipoprotein E2/metabolism; Apolipoprotein E3/metabolism; Apolipoprotein E4/metabolism; Apolipoproteins E/metabolism; Cell Line; Humans; Mice; Mice, Knockout; Neurites/metabolism; Olfactory Mucosa/metabolism; Olfactory Mucosa/ultrastructure; Protein Isoforms/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
MOUSE:LRP6 |
involved_in |
GO:0010976: positive regulation of neuron projection development |
ECO:0000316: genetic interaction evidence used in manual assertion |
UniProtKB:P02649 |
P |
|
Seeded From UniProt |
complete |
|
involved_in |
GO:0010976: positive regulation of neuron projection development |
ECO:0000314: direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
MOUSE:APOE |
involved_in |
GO:0010976: positive regulation of neuron projection development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | |
|
involved_in |
GO:0010976: positive regulation of neuron projection development |
ECO:0000314: direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0001997) |
Seeded From UniProt |
complete | ||
Notes
See also
References
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