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HUMAN:CLUS

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CLU (ECO:0000312 with HGNC:HGNC:2095)
Protein Name(s) Clusterin

Aging-associated gene 4 protein (ECO:0000303 with Ref.20) Apolipoprotein J (ECO:0000303 with PMID:2387851[1]) Apo-J Complement cytolysis inhibitor (ECO:0000303 with PMID:2780565[2]) CLI (ECO:0000303 with PMID:2780565[2]) Complement-associated protein SP-40,40 (ECO:0000303 with PMID:1903064[3]) Ku70-binding protein 1 NA1/NA2 (ECO:0000303 with PMID:1903064[3]) Sulfated glycoprotein 2 (ECO:0000303 with PMID:1924317[4]) SGP-2 (ECO:0000303 with PMID:1924317[4]) Testosterone-repressed prostate message 2 (ECO:0000250 with UniProtKB:P05371) TRPM-2 (ECO:0000303 with PMID:8181474[5]) Clusterin beta chain ApoJalpha Complement cytolysis inhibitor a chain Clusterin alpha chain ApoJbeta Complement cytolysis inhibitor b chain

External Links
UniProt P10909
EMBL M25915
M63379
M63376
M63377
M63378
M64722
AK093399
AK313870
CR599675
BX648414
AY341244
AF311103
BC010514
BC019588
BU150467
J02908
M74816
L00974
X14723
AY513288
CCDS CCDS47832.1
PIR S43646
RefSeq NP_001822.3
BioGrid 107603
DIP DIP-37546N
IntAct P10909
MINT P10909
STRING 9606.ENSP00000315130
DrugBank DB09130
DB01593
DB14487
DB14533
CarbonylDB P10909
GlyConnect 759
iPTMnet P10909
PhosphoSitePlus P10909
BioMuta CLU
DMDM 116533
DOSAC-COBS-2DPAGE P10909
OGP P10909
REPRODUCTION-2DPAGE IPI00291262
SWISS-2DPAGE P10909
CPTAC CPTAC-478
CPTAC-479
CPTAC-661
CPTAC-662
CPTAC-728
non-CPTAC-1096
non-CPTAC-1097
non-CPTAC-1098
EPD P10909
jPOST P10909
MassIVE P10909
MaxQB P10909
PaxDb P10909
PeptideAtlas P10909
PRIDE P10909
ProteomicsDB 52663
52664
52665
52666
52667
ABCD P10909
DNASU 1191
Ensembl ENST00000316403
ENST00000405140
ENST00000523500
GeneID 1191
KEGG hsa:1191
UCSC uc003xfw.3
CTD 1191
DisGeNET 1191
GeneCards CLU
HGNC HGNC:2095
HPA CAB016253
HPA000572
MIM 185430
neXtProt NX_P10909
NIAGADS ENSG00000120885
OpenTargets ENSG00000120885
PharmGKB PA26620
eggNOG ENOG410IHRB
ENOG410YYKB
GeneTree ENSGT00530000063668
InParanoid P10909
KO K17252
OMA NPKFMET
OrthoDB 1377476at2759
PhylomeDB P10909
TreeFam TF333030
Reactome R-HSA-114608
R-HSA-166665
R-HSA-6803157
R-HSA-977606
SIGNOR P10909
ChiTaRS CLU
GeneWiki Clusterin
GenomeRNAi 1191
Pharos P10909
PMAP-CutDB P10909
PRO PR:P10909
Proteomes UP000005640
Bgee ENSG00000120885
ExpressionAtlas P10909
Genevisible P10909
GO GO:0097440
GO:0072562
GO:0009986
GO:0042583
GO:0062023
GO:0005737
GO:0005829
GO:0070062
GO:0005576
GO:0005615
GO:0005794
GO:0043231
GO:0005743
GO:0005739
GO:0097418
GO:0005634
GO:0099020
GO:0048471
GO:0031093
GO:0032991
GO:0034366
GO:0045202
GO:0001540
GO:0051087
GO:0050750
GO:0051787
GO:0046982
GO:0044877
GO:0005102
GO:0048156
GO:0031625
GO:0051082
GO:0019730
GO:0000902
GO:0032286
GO:0051131
GO:0061077
GO:0061741
GO:0006956
GO:0006958
GO:0002434
GO:0045087
GO:0097193
GO:0006629
GO:0001774
GO:0061518
GO:1905907
GO:1902430
GO:0060548
GO:1905892
GO:1905895
GO:1902230
GO:0032463
GO:0090201
GO:1903573
GO:0002576
GO:1905908
GO:1902004
GO:0043065
GO:0010628
GO:2001244
GO:1902998
GO:1901216
GO:0051092
GO:0045429
GO:0032436
GO:0032464
GO:0048260
GO:1902949
GO:0032760
GO:2000060
GO:0017038
GO:0050821
GO:0061740
GO:1900221
GO:0042127
GO:0030449
GO:1901214
GO:1902847
GO:0001836
GO:0051788
GO:0009615
GO:0043691
InterPro IPR016016
IPR000753
IPR016015
IPR033986
IPR016014
PANTHER PTHR10970
PTHR10970:SF1
Pfam PF01093
PIRSF PIRSF002368
SMART SM00035
SM00030
PROSITE PS00492
PS00493

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0002434

immune complex clearance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06890

P

Seeded From UniProt

involved_in

GO:0048260

positive regulation of receptor-mediated endocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25473

P

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:19137541[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0042127

regulation of cell population proliferation

PMID:19137541[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0005743

mitochondrial inner membrane

PMID:17689225[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:17689225[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0050821

protein stabilization

PMID:12176985[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0048156

tau protein binding

PMID:25051234[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10636

F

Seeded From UniProt

enables

GO:0001540

amyloid-beta binding

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

F

  • has_direct_input:(ComplexPortal:CPX-1180)

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0099020

perinuclear endoplasmic reticulum lumen

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005829

cytosol

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0043231

intracellular membrane-bounded organelle

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)

Seeded From UniProt

colocalizes_with

GO:0016020

membrane

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)

Seeded From UniProt

colocalizes_with

GO:0005856

cytoskeleton

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)
  • part_of:(UBERON:0000955)|part_of:(CL:0000127)
  • part_of:(UBERON:0000955)

Seeded From UniProt

enables

GO:0005102

signaling receptor binding

PMID:27477018[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NZC2

F

Seeded From UniProt

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06890

P

Seeded From UniProt

enables

GO:0051082

unfolded protein binding

PMID:25402950[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:9228033[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P98164

F

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05371

P

Seeded From UniProt

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05371

P

  • regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)
  • occurs_in:(UBERON:0000956)

Seeded From UniProt

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05371

P

  • regulates_o_occurs_in:(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000008415)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000006118)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000020918)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000008015)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000019422)

Seeded From UniProt

part_of

GO:0005576

extracellular region

PMID:27068509[15]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0007318)

Seeded From UniProt

involved_in

GO:1905895

negative regulation of cellular response to tunicamycin

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1905892

negative regulation of cellular response to thapsigargin

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0060548

negative regulation of cell death

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1903573

negative regulation of response to endoplasmic reticulum stress

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

colocalizes_with

GO:0071944

cell periphery

PMID:21803450[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0061741

chaperone-mediated protein transport involved in chaperone-mediated autophagy

PMID:9228033[14]

ECO:0000305

curator inference used in manual assertion

GO:0001540,GO:0032991,GO:0048260,GO:0050750

P

Seeded From UniProt

involved_in

GO:0061740

protein targeting to lysosome involved in chaperone-mediated autophagy

PMID:9228033[14]

ECO:0000305

curator inference used in manual assertion

GO:0001540,GO:0032991,GO:0048260,GO:0050750

P

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:9228033[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0048260

positive regulation of receptor-mediated endocytosis

PMID:9228033[14]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:C0HL13

P

Seeded From UniProt

enables

GO:0001540

amyloid-beta binding

PMID:9228033[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

enables

GO:0044877

protein-containing complex binding

PMID:22179788[10]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-1180

F

Seeded From UniProt

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[17]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

enables

GO:0001540

amyloid-beta binding

PMID:23106396[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0044877

protein-containing complex binding

PMID:23106396[18]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-1180
UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:23106396[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:17567961[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006530)

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:17567961[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006530)|part_of:(GO:0009986)
  • part_of:(CL:0000019)

Seeded From UniProt

part_of

GO:0009986

cell surface

PMID:17567961[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000019)

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25473

C

Seeded From UniProt

enables

GO:0051087

chaperone binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25473

F

Seeded From UniProt

part_of

GO:0070062

extracellular exosome

PMID:23533145[20]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:23658023[21]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(CL:0002322)

Seeded From UniProt

involved_in

GO:1902998

positive regulation of neurofibrillary tangle assembly

PMID:15897157[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902949

positive regulation of tau-protein kinase activity

PMID:15897157[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902847

regulation of neuronal signal transduction

PMID:21397462[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902430

negative regulation of amyloid-beta formation

PMID:12047389[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902430

negative regulation of amyloid-beta formation

PMID:17412999[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06890

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

PMID:15897157[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901214

regulation of neuron death

PMID:9560017[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901214

regulation of neuron death

PMID:17412999[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1900221

regulation of amyloid-beta clearance

PMID:24446231[28]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000129)
  • occurs_in:(CL:0000127)

Seeded From UniProt

part_of

GO:0097440

apical dendrite

PMID:9560017[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0097418

neurofibrillary tangle

PMID:9560017[27]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002728)

Seeded From UniProt

part_of

GO:0097418

neurofibrillary tangle

PMID:15897157[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0061518

microglial cell proliferation

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0051131

chaperone-mediated protein complex assembly

PMID:17412999[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0032286

central nervous system myelin maintenance

PMID:21543606[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002316)

Seeded From UniProt

involved_in

GO:0017038

protein import

PMID:24446231[28]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000129)
  • occurs_in:(CL:0000127)

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:9560017[27]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)

Seeded From UniProt

involved_in

GO:0001774

microglial cell activation

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0000902

cell morphogenesis

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0072562

blood microparticle

PMID:22516433[30]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0070062

extracellular exosome

PMID:19199708[31]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001831)

Seeded From UniProt

part_of

GO:0070062

extracellular exosome

PMID:19056867[32]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001088)

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:16502470[33]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001914)

Seeded From UniProt

involved_in

GO:0031334

positive regulation of protein complex assembly

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:9228033[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:C0HL13

F

Seeded From UniProt

involved_in

GO:0006629

lipid metabolic process

PMID:2387851[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

PMID:16113678[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0051788

response to misfolded protein

PMID:19996109[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:19996109[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02675

F

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:19996109[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02768

F

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:19996109[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P00450

F

Seeded From UniProt

part_of

GO:0034366

spherical high-density lipoprotein particle

PMID:16682745[36]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:16113678[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[37]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001496)

Seeded From UniProt

part_of

GO:0005739

mitochondrion

PMID:16113678[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:16113678[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:20551380[37]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001496)

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:19996109[35]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0001836

release of cytochrome c from mitochondria

PMID:16113678[34]

ECO:0000305

curator inference used in manual assertion

GO:0031333

P

Seeded From UniProt

involved_in

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

PMID:20068069[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0061077

chaperone-mediated protein folding

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:20068069[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0050821

protein stabilization

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:20068069[38]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:20068069[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0031625

ubiquitin protein ligase binding

PMID:20068069[38]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

NOT|enables

GO:0016887

ATPase activity

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0009615

response to virus

PMID:16548883[40]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103786
UniProtKB:P10909

P

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861171
UniProtKB:P10909

F

Seeded From UniProt

involved_in

GO:0032463

negative regulation of protein homooligomerization

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103786
UniProtKB:P10909

P

Seeded From UniProt

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103786
UniProtKB:P10909

P

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861171
RGD:3907
UniProtKB:P10909

C

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861171
RGD:3907
UniProtKB:P10909

C

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

involved_in

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

involved_in

GO:0002434

immune complex clearance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:21567405[42]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

PMID:21567405[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0097193

intrinsic apoptotic signaling pathway

PMID:21567405[42]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21567405[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1905908

positive regulation of amyloid fibril formation

PMID:20005821[43]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

PMID:9228033[14]
PMID:23106396[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

part_of

GO:0005576

extracellular region

PMID:23164821[44]
Reactome:R-HSA-8852580
Reactome:R-HSA-6810643
Reactome:R-HSA-481007
PMID:25051234[9]
PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:23164821[44]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

involved_in

GO:0060548

negative regulation of cell death

PMID:23164821[44]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0090201

negative regulation of release of cytochrome c from mitochondria

PMID:21803450[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0006956

complement activation

PMID:1585460[45]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0043691

reverse cholesterol transport

PMID:16682745[36]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

part_of

GO:0031093

platelet alpha granule lumen

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

involved_in

GO:0030449

regulation of complement activation

Reactome:R-HSA-977606

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0019730

antimicrobial humoral response

Reactome:R-HSA-6803157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0492
UniProtKB-SubCell:SL-0166

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

involved_in

GO:0006958

complement activation, classical pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0180

P

Seeded From UniProt

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

part_of

GO:0042583

chromaffin granule

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0061

C

Seeded From UniProt

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

enables

GO:0046982

protein heterodimerization activity

PMID:25051234[9]
PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:25051234[9]
PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

involved_in

GO:0002434

immune complex clearance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06890

P

Seeded From UniProt

involved_in

GO:0048260

positive regulation of receptor-mediated endocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25473

P

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:19137541[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0042127

regulation of cell population proliferation

PMID:19137541[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0005743

mitochondrial inner membrane

PMID:17689225[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:17689225[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0050821

protein stabilization

PMID:12176985[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0048156

tau protein binding

PMID:25051234[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10636

F

Seeded From UniProt

enables

GO:0001540

amyloid-beta binding

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

F

  • has_direct_input:(ComplexPortal:CPX-1180)

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:22689054[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11021

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:8555189[46]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q04771

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:8555189[46]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P37173

F

Seeded From UniProt

part_of

GO:0099020

perinuclear endoplasmic reticulum lumen

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005829

cytosol

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0043231

intracellular membrane-bounded organelle

PMID:22689054[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:25051234[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00499

F

Seeded From UniProt

colocalizes_with

GO:0016020

membrane

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)

Seeded From UniProt

colocalizes_with

GO:0005856

cytoskeleton

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:25051234[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)
  • part_of:(UBERON:0000955)|part_of:(CL:0000127)
  • part_of:(UBERON:0000955)

Seeded From UniProt

enables

GO:0005102

signaling receptor binding

PMID:27477018[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NZC2

F

Seeded From UniProt

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06890

P

Seeded From UniProt

enables

GO:0051082

unfolded protein binding

PMID:25402950[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:1905908

positive regulation of amyloid fibril formation

PMID:20005821[43]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:9228033[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P98164

F

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

PMID:9228033[14]
PMID:23106396[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

part_of

GO:0005576

extracellular region

PMID:23164821[44]
Reactome:R-HSA-8852580
Reactome:R-HSA-6810643
Reactome:R-HSA-481007
PMID:25051234[9]
PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:23164821[44]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

involved_in

GO:0060548

negative regulation of cell death

PMID:23164821[44]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05371

P

Seeded From UniProt

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05371

P

  • regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)
  • occurs_in:(UBERON:0000956)

Seeded From UniProt

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05371

P

  • regulates_o_occurs_in:(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000008415)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000006118)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000020918)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000008015)|regulates_o_occurs_in(CL:0002609)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000019422)

Seeded From UniProt

part_of

GO:0005576

extracellular region

PMID:27068509[15]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0007318)

Seeded From UniProt

involved_in

GO:1905895

negative regulation of cellular response to tunicamycin

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1905892

negative regulation of cellular response to thapsigargin

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0060548

negative regulation of cell death

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1903573

negative regulation of response to endoplasmic reticulum stress

PMID:21803450[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

colocalizes_with

GO:0071944

cell periphery

PMID:21803450[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0090201

negative regulation of release of cytochrome c from mitochondria

PMID:21803450[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0061741

chaperone-mediated protein transport involved in chaperone-mediated autophagy

PMID:9228033[14]

ECO:0000305

curator inference used in manual assertion

GO:0001540,GO:0032991,GO:0048260,GO:0050750

P

Seeded From UniProt

involved_in

GO:0061740

protein targeting to lysosome involved in chaperone-mediated autophagy

PMID:9228033[14]

ECO:0000305

curator inference used in manual assertion

GO:0001540,GO:0032991,GO:0048260,GO:0050750

P

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:9228033[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0048260

positive regulation of receptor-mediated endocytosis

PMID:9228033[14]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:C0HL13

P

Seeded From UniProt

enables

GO:0001540

amyloid-beta binding

PMID:9228033[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

enables

GO:0044877

protein-containing complex binding

PMID:22179788[10]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-1180

F

Seeded From UniProt

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[17]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

enables

GO:0001540

amyloid-beta binding

PMID:23106396[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0044877

protein-containing complex binding

PMID:23106396[18]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-1180
UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

PMID:23106396[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:23106396[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:17567961[19]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O95925

F

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:17567961[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006530)

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:17567961[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006530)|part_of:(GO:0009986)
  • part_of:(CL:0000019)

Seeded From UniProt

part_of

GO:0009986

cell surface

PMID:17567961[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000019)

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25473

C

Seeded From UniProt

enables

GO:0051087

chaperone binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25473

F

Seeded From UniProt

part_of

GO:0070062

extracellular exosome

PMID:23533145[20]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:23658023[21]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(CL:0002322)

Seeded From UniProt

involved_in

GO:1902998

positive regulation of neurofibrillary tangle assembly

PMID:15897157[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902949

positive regulation of tau-protein kinase activity

PMID:15897157[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902847

regulation of neuronal signal transduction

PMID:21397462[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902430

negative regulation of amyloid-beta formation

PMID:12047389[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902430

negative regulation of amyloid-beta formation

PMID:17412999[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06890

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

PMID:15897157[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901214

regulation of neuron death

PMID:9560017[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1901214

regulation of neuron death

PMID:17412999[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1900221

regulation of amyloid-beta clearance

PMID:24446231[28]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000129)
  • occurs_in:(CL:0000127)

Seeded From UniProt

part_of

GO:0097440

apical dendrite

PMID:9560017[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0097418

neurofibrillary tangle

PMID:9560017[27]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002728)

Seeded From UniProt

part_of

GO:0097418

neurofibrillary tangle

PMID:15897157[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0061518

microglial cell proliferation

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0051131

chaperone-mediated protein complex assembly

PMID:17412999[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0032286

central nervous system myelin maintenance

PMID:21543606[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002316)

Seeded From UniProt

involved_in

GO:0017038

protein import

PMID:24446231[28]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000129)
  • occurs_in:(CL:0000127)

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:9560017[27]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)

Seeded From UniProt

involved_in

GO:0001774

microglial cell activation

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0000902

cell morphogenesis

PMID:15857407[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0072562

blood microparticle

PMID:22516433[30]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0070062

extracellular exosome

PMID:19199708[31]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001831)

Seeded From UniProt

part_of

GO:0070062

extracellular exosome

PMID:19056867[32]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001088)

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:16502470[33]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001914)

Seeded From UniProt

involved_in

GO:0031334

positive regulation of protein complex assembly

PMID:22179788[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:9228033[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:C0HL13

F

Seeded From UniProt

involved_in

GO:0006956

complement activation

PMID:1585460[45]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0006629

lipid metabolic process

PMID:2387851[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

involved_in

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

PMID:16113678[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0051788

response to misfolded protein

PMID:19996109[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:19996109[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02675

F

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:19996109[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02768

F

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:19996109[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P00450

F

Seeded From UniProt

involved_in

GO:0043691

reverse cholesterol transport

PMID:16682745[36]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

part_of

GO:0034366

spherical high-density lipoprotein particle

PMID:16682745[36]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:16113678[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[37]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001496)

Seeded From UniProt

part_of

GO:0005739

mitochondrion

PMID:16113678[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:16113678[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:20551380[37]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001496)

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:19996109[35]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:16113678[34]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

involved_in

GO:0001836

release of cytochrome c from mitochondria

PMID:16113678[34]

ECO:0000305

curator inference used in manual assertion

GO:0031333

P

Seeded From UniProt

involved_in

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

PMID:20068069[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0061077

chaperone-mediated protein folding

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:20068069[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0050821

protein stabilization

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:20068069[38]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:20068069[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0031625

ubiquitin protein ligase binding

PMID:20068069[38]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

NOT|enables

GO:0016887

ATPase activity

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0009615

response to virus

PMID:16548883[40]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:11123922[39]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103786
UniProtKB:P10909

P

Seeded From UniProt

enables

GO:0051787

misfolded protein binding

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861171
UniProtKB:P10909

F

Seeded From UniProt

involved_in

GO:0032463

negative regulation of protein homooligomerization

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103786
UniProtKB:P10909

P

Seeded From UniProt

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103786
UniProtKB:P10909

P

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861171
RGD:3907
UniProtKB:P10909

C

Seeded From UniProt

part_of

GO:0005615

extracellular space

PMID:21873635[41]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861171
RGD:3907
UniProtKB:P10909

C

Seeded From UniProt

part_of

GO:0031093

platelet alpha granule lumen

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

involved_in

GO:0030449

regulation of complement activation

Reactome:R-HSA-977606

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0019730

antimicrobial humoral response

Reactome:R-HSA-6803157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

part_of

GO:0005576

extracellular region

Reactome:R-HSA-8852580

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6810643

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

part_of

GO:0005576

extracellular region

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:26496610[47]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P30101

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:25451228[48]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18509

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:22528093[49]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:22179788[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000093

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:20195357[50]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P37231

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:20195357[50]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01100

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:17170699[51]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P30101

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:17043677[52]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NRI5

F

Seeded From UniProt

involved_in

GO:1905907

negative regulation of amyloid fibril formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

involved_in

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

C

Seeded From UniProt

involved_in

GO:0002434

immune complex clearance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06890
ensembl:ENSMUSP00000022616

P

Seeded From UniProt

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0492
UniProtKB-SubCell:SL-0166

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

involved_in

GO:0006958

complement activation, classical pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0180

P

Seeded From UniProt

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

part_of

GO:0005576

extracellular region

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

part_of

GO:0005739

mitochondrion

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

part_of

GO:0042583

chromaffin granule

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0061

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0166

C

Seeded From UniProt

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:21567405[42]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

PMID:21567405[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0097193

intrinsic apoptotic signaling pathway

PMID:21567405[42]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21567405[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:21567405[42]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07817-1

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:23805218[53]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NZV6

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:23805218[53]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05067:PRO_0000000092

F

Seeded From UniProt

enables

GO:0046982

protein heterodimerization activity

PMID:25051234[9]
PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:25051234[9]
PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

part_of

GO:0005576

extracellular region

PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

part_of

GO:0032991

protein-containing complex

PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

part_of

GO:0005576

extracellular region

PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

enables

GO:0046982

protein heterodimerization activity

PMID:25051234[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 de Silva, HV et al. (1990) Purification and characterization of apolipoprotein J. J. Biol. Chem. 265 14292-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 Jenne, DE & Tschopp, J (1989) Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc. Natl. Acad. Sci. U.S.A. 86 7123-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 James, RW et al. () Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis. Arterioscler. Thromb. 11 645-52 PubMed GONUTS page
  4. ↑ 4.0 4.1 Danik, M et al. (1991) Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death. Proc. Natl. Acad. Sci. U.S.A. 88 8577-81 PubMed GONUTS page
  5. ↑ Wong, P et al. (1994) Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration. Eur. J. Biochem. 221 917-25 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Rizzi, F et al. (2009) Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J. Cell. Physiol. 219 314-23 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Ranney, MK et al. (2007) Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer. Biochim. Biophys. Acta 1772 1103-11 PubMed GONUTS page
  8. ↑ 8.0 8.1 Poon, S et al. (2002) Mildly acidic pH activates the extracellular molecular chaperone clusterin. J. Biol. Chem. 277 39532-40 PubMed GONUTS page
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 9.18 9.19 9.20 9.21 9.22 9.23 9.24 9.25 9.26 Zhou, Y et al. (2014) Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE 9 e103187 PubMed GONUTS page
  10. ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 Narayan, P et al. (2011) The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. Nat. Struct. Mol. Biol. 19 79-83 PubMed GONUTS page
  11. ↑ 11.00 11.01 11.02 11.03 11.04 11.05 11.06 11.07 11.08 11.09 11.10 Li, N et al. (2013) GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene 32 1933-42 PubMed GONUTS page
  12. ↑ 12.0 12.1 Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page
  13. ↑ 13.0 13.1 Rohne, P et al. (2014) The chaperone activity of clusterin is dependent on glycosylation and redox environment. Cell. Physiol. Biochem. 34 1626-39 PubMed GONUTS page
  14. ↑ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 14.11 14.12 14.13 14.14 14.15 Hammad, SM et al. (1997) Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J. Biol. Chem. 272 18644-9 PubMed GONUTS page
  15. ↑ 15.0 15.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  16. ↑ 16.00 16.01 16.02 16.03 16.04 16.05 16.06 16.07 16.08 16.09 16.10 16.11 Kögel, D et al. (2012) The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis. Neurobiol. Aging 33 2200-9 PubMed GONUTS page
  17. ↑ 17.0 17.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 18.3 18.4 18.5 18.6 18.7 18.8 Narayan, P et al. (2012) Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones. Biochemistry 51 9270-6 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 19.3 19.4 19.5 19.6 Wang, Z et al. (2007) Characterization of an eppin protein complex from human semen and spermatozoa. Biol. Reprod. 77 476-84 PubMed GONUTS page
  20. ↑ 20.0 20.1 Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  21. ↑ 21.0 21.1 Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 22.3 22.4 22.5 22.6 22.7 Martin-Rehrmann, MD et al. (2005) Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Neurotox Res 7 231-42 PubMed GONUTS page
  23. ↑ 23.0 23.1 Lancaster, TM et al. (2011) Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene. Eur Neuropsychopharmacol 21 880-4 PubMed GONUTS page
  24. ↑ 24.0 24.1 Hatters, DM et al. (2002) Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin. Eur. J. Biochem. 269 2789-94 PubMed GONUTS page
  25. ↑ 25.0 25.1 25.2 25.3 25.4 25.5 Yerbury, JJ et al. (2007) The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J. 21 2312-22 PubMed GONUTS page
  26. ↑ 26.00 26.01 26.02 26.03 26.04 26.05 26.06 26.07 26.08 26.09 26.10 26.11 Xie, Z et al. (2005) Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J. Neurochem. 93 1038-46 PubMed GONUTS page
  27. ↑ 27.0 27.1 27.2 27.3 27.4 27.5 27.6 27.7 Giannakopoulos, P et al. (1998) Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol. 95 387-94 PubMed GONUTS page
  28. ↑ 28.0 28.1 28.2 28.3 Mulder, SD et al. (2014) Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. Glia 62 493-503 PubMed GONUTS page
  29. ↑ 29.0 29.1 Braskie, MN et al. (2011) Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J. Neurosci. 31 6764-70 PubMed GONUTS page
  30. ↑ 30.0 30.1 Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
  31. ↑ 31.0 31.1 Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  32. ↑ 32.0 32.1 Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  33. ↑ 33.0 33.1 Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  34. ↑ 34.00 34.01 34.02 34.03 34.04 34.05 34.06 34.07 34.08 34.09 34.10 Zhang, H et al. (2005) Clusterin inhibits apoptosis by interacting with activated Bax. Nat. Cell Biol. 7 909-15 PubMed GONUTS page
  35. ↑ 35.0 35.1 35.2 35.3 35.4 35.5 35.6 35.7 35.8 35.9 Wyatt, AR & Wilson, MR (2010) Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. J. Biol. Chem. 285 3532-9 PubMed GONUTS page
  36. ↑ 36.0 36.1 36.2 36.3 Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page
  37. ↑ 37.0 37.1 37.2 37.3 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  38. ↑ 38.0 38.1 38.2 38.3 38.4 38.5 38.6 38.7 38.8 38.9 Zoubeidi, A et al. (2010) Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol. Cancer Res. 8 119-30 PubMed GONUTS page
  39. ↑ 39.0 39.1 39.2 39.3 39.4 39.5 39.6 39.7 39.8 39.9 Poon, S et al. (2000) Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state. Biochemistry 39 15953-60 PubMed GONUTS page
  40. ↑ 40.0 40.1 Leong, WF & Chow, VT (2006) Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell. Microbiol. 8 565-80 PubMed GONUTS page
  41. ↑ 41.00 41.01 41.02 41.03 41.04 41.05 41.06 41.07 41.08 41.09 41.10 41.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  42. ↑ 42.0 42.1 42.2 42.3 42.4 42.5 42.6 42.7 42.8 Kim, N et al. (2012) Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J. Cell. Physiol. 227 1157-67 PubMed GONUTS page
  43. ↑ 43.0 43.1 Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page
  44. ↑ 44.0 44.1 44.2 44.3 44.4 44.5 Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page
  45. ↑ 45.0 45.1 Jenne, DE & Tschopp, J (1992) Clusterin: the intriguing guises of a widely expressed glycoprotein. Trends Biochem. Sci. 17 154-9 PubMed GONUTS page
  46. ↑ 46.0 46.1 Reddy, KB et al. (1996) Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin. Biochemistry 35 309-14 PubMed GONUTS page
  47. ↑ Hein, MY et al. (2015) A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 163 712-23 PubMed GONUTS page
  48. ↑ Lee, JH et al. (2014) PACAP inhibits tumor growth and interferes with clusterin in cervical carcinomas. FEBS Lett. 588 4730-9 PubMed GONUTS page
  49. ↑ Calero, M et al. (2012) Search for amyloid-binding proteins by affinity chromatography. Methods Mol. Biol. 849 213-23 PubMed GONUTS page
  50. ↑ 50.0 50.1 Miyamoto-Sato, E et al. (2010) A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS ONE 5 e9289 PubMed GONUTS page
  51. ↑ Jessop, CE et al. (2007) ERp57 is essential for efficient folding of glycoproteins sharing common structural domains. EMBO J. 26 28-40 PubMed GONUTS page
  52. ↑ Camargo, LM et al. (2007) Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol. Psychiatry 12 74-86 PubMed GONUTS page
  53. ↑ 53.0 53.1 Chen, P et al. (2013) Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease. PLoS ONE 8 e66384 PubMed GONUTS page
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