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PMID:23542032
| Citation |
Yamashita, A, Taniwaki, T, Kaikoi, Y and Yamazaki, T (2013) Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. FEBS Lett. 587:1299-303 |
|---|---|
| Abstract |
The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show that knockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB-crystallin (αBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23 plays a protective role against UVC by accumulating αBC in the close vicinity of the ER. |
| Links |
PubMed Online version:10.1016/j.febslet.2013.03.024 |
| Keywords |
Animals; Cell Death/radiation effects; DNA Damage; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum/radiation effects; Gene Knockdown Techniques; HEK293 Cells; Humans; Membrane Proteins/chemistry; Membrane Proteins/deficiency; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Signal Transduction/radiation effects; Ultraviolet Rays/adverse effects; alpha-Crystallin B Chain/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:Q3UBX0 |
F |
Seeded From UniProt |
complete | ||
|
MOUSE:TM109 |
acts_upstream_of_or_within |
GO:0060548: negative regulation of cell death |
ECO:0000266: sequence orthology evidence used in manual assertion |
UniProtKB:Q9BVC6 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:TM109 |
acts_upstream_of_or_within |
GO:0071480: cellular response to gamma radiation |
ECO:0000266: sequence orthology evidence used in manual assertion |
UniProtKB:Q9BVC6 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:TM109 |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P02511 |
F |
Seeded From UniProt |
complete | |
|
HUMAN:TM109 |
involved_in |
GO:0060548: negative regulation of cell death |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
HUMAN:TM109 |
involved_in |
GO:0071480: cellular response to gamma radiation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010941: regulation of cell death |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071480: cellular response to gamma radiation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010941: regulation of cell death |
ECO:0000266: sequence orthology evidence used in manual assertion |
UniProtKB:P02511 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071480: cellular response to gamma radiation |
ECO:0000266: sequence orthology evidence used in manual assertion |
UniProtKB:P02511 |
P |
Seeded From UniProt |
complete | ||
Notes
See also
References
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