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PMID:23542032

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Citation

Yamashita, A, Taniwaki, T, Kaikoi, Y and Yamazaki, T (2013) Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. FEBS Lett. 587:1299-303

Abstract

The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show that knockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB-crystallin (αBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23 plays a protective role against UVC by accumulating αBC in the close vicinity of the ER.

Links

PubMed Online version:10.1016/j.febslet.2013.03.024

Keywords

Animals; Cell Death/radiation effects; DNA Damage; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum/radiation effects; Gene Knockdown Techniques; HEK293 Cells; Humans; Membrane Proteins/chemistry; Membrane Proteins/deficiency; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Signal Transduction/radiation effects; Ultraviolet Rays/adverse effects; alpha-Crystallin B Chain/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CRYAB

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q3UBX0

F

Seeded From UniProt

complete

MOUSE:TM109

acts_upstream_of_or_within

GO:0060548: negative regulation of cell death

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:Q9BVC6

P

Seeded From UniProt

complete

MOUSE:TM109

acts_upstream_of_or_within

GO:0071480: cellular response to gamma radiation

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:Q9BVC6

P

Seeded From UniProt

complete

MOUSE:TM109

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P02511

F

Seeded From UniProt

complete

HUMAN:TM109

involved_in

GO:0060548: negative regulation of cell death

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TM109

involved_in

GO:0071480: cellular response to gamma radiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CRYAB

involved_in

GO:0010941: regulation of cell death

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CRYAB

involved_in

GO:0071480: cellular response to gamma radiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CRYAB

acts_upstream_of_or_within

GO:0010941: regulation of cell death

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P02511

P

Seeded From UniProt

complete

MOUSE:CRYAB

acts_upstream_of_or_within

GO:0071480: cellular response to gamma radiation

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P02511

P

Seeded From UniProt

complete

Notes

See also

References

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