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HUMAN:RELB
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | RELB | |
Protein Name(s) | Transcription factor RelB
I-Rel | |
External Links | ||
UniProt | Q01201 | |
EMBL | M83221 AF043463 AF043454 AF043455 AF043456 AF043457 AF043458 AF043459 AF043460 AF043461 AF043462 DQ314887 BC028013 | |
CCDS | CCDS46110.1 | |
PIR | A42617 | |
RefSeq | NP_006500.2 | |
UniGene | Hs.654402 | |
ProteinModelPortal | Q01201 | |
SMR | Q01201 | |
BioGrid | 111903 | |
DIP | DIP-27531N | |
IntAct | Q01201 | |
MINT | MINT-1131428 | |
STRING | 9606.ENSP00000221452 | |
PhosphoSite | Q01201 | |
DMDM | 92090634 | |
MaxQB | Q01201 | |
PaxDb | Q01201 | |
PRIDE | Q01201 | |
DNASU | 5971 | |
Ensembl | ENST00000221452 | |
GeneID | 5971 | |
KEGG | hsa:5971 | |
UCSC | uc021uvp.1 | |
CTD | 5971 | |
GeneCards | GC19P045504 | |
HGNC | HGNC:9956 | |
HPA | CAB007753 HPA040506 | |
MIM | 604758 | |
neXtProt | NX_Q01201 | |
PharmGKB | PA34322 | |
eggNOG | NOG119056 | |
GeneTree | ENSGT00500000044765 | |
HOGENOM | HOG000148598 | |
HOVERGEN | HBG017021 | |
InParanoid | Q01201 | |
KO | K09253 | |
OMA | DDGFAYD | |
OrthoDB | EOG7VHSWT | |
PhylomeDB | Q01201 | |
TreeFam | TF325632 | |
GeneWiki | RELB | |
GenomeRNAi | 5971 | |
NextBio | 23245 | |
PRO | PR:Q01201 | |
Proteomes | UP000005640 | |
Bgee | Q01201 | |
CleanEx | HS_RELB | |
ExpressionAtlas | Q01201 | |
Genevestigator | Q01201 | |
GO | GO:0005737 GO:0005829 GO:0005815 GO:0005634 GO:0001047 GO:0003700 GO:0003714 GO:0019882 GO:0071470 GO:0032922 GO:0043011 GO:1903507 GO:0038061 GO:0010628 GO:0045063 GO:0006351 | |
Gene3D | 2.60.40.10 2.60.40.340 | |
InterPro | IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539 | |
Pfam | PF00554 | |
PRINTS | PR00057 | |
SMART | SM00429 | |
SUPFAM | SSF49417 SSF81296 | |
PROSITE | PS01204 PS50254 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000315 |
P |
Fig. 4 |
complete | |||||
GO:0005634 |
nucleus |
ECO:0000314 |
C |
Fig. 3C |
complete | |||||
part_of |
GO:0017053 |
transcriptional repressor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
InterPro:IPR000451 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030098 |
lymphocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0011274 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0038061 |
NIK/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103289 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000652441 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000652441 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000652441 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103289 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000652441 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103290 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000652441 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0260632 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103290 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071470 |
cellular response to osmotic stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A8H1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A8H1 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A8H1 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045063 |
T-helper 1 cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043011 |
myeloid dendritic cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042088 |
T-helper 1 type immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0038061 |
NIK/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032922 |
circadian regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019882 |
antigen processing and presentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04863 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000451 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000451 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0038061 |
NIK/NF-kappaB signaling |
Reactome:R-HSA-5676590 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5607741 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5660980 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
Reactome:R-HSA-5621481 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page
- ↑ El Gazzar, M et al. (2009) Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29 1959-71 PubMed GONUTS page
- ↑ 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page
- ↑ Sharfe, N et al. (2015) The effects of RelB deficiency on lymphocyte development and function. J. Autoimmun. 65 90-100 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ruben, SM et al. (1992) I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Genes Dev. 6 745-60 PubMed GONUTS page
- ↑ Deloukas, P et al. (1994) The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12. Genomics 19 592-4 PubMed GONUTS page
c
- GO:0007249 ! canonical NF-kappaB signal transduction
- Catarrhini
- GO:0071470 ! cellular response to osmotic stress
- GO:0005813 ! centrosome
- Chordata
- GO:0003682 ! chromatin binding
- GO:0032922 ! circadian regulation of gene expression
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
d
m
n
- GO:0032688 ! negative regulation of interferon-beta production
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0038061 ! non-canonical NF-kappaB signal transduction
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
r
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0034097 ! response to cytokine
- GO:0048511 ! rhythmic process
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
- GO:0000980 ! RNA polymerase II distal enhancer sequence-specific DNA binding
t