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HUMAN:RELB

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RELB
Protein Name(s) Transcription factor RelB

I-Rel

External Links
UniProt Q01201
EMBL M83221
AF043463
AF043454
AF043455
AF043456
AF043457
AF043458
AF043459
AF043460
AF043461
AF043462
DQ314887
BC028013
CCDS CCDS46110.1
PIR A42617
RefSeq NP_006500.2
UniGene Hs.654402
ProteinModelPortal Q01201
SMR Q01201
BioGrid 111903
DIP DIP-27531N
IntAct Q01201
MINT MINT-1131428
STRING 9606.ENSP00000221452
PhosphoSite Q01201
DMDM 92090634
MaxQB Q01201
PaxDb Q01201
PRIDE Q01201
DNASU 5971
Ensembl ENST00000221452
GeneID 5971
KEGG hsa:5971
UCSC uc021uvp.1
CTD 5971
GeneCards GC19P045504
HGNC HGNC:9956
HPA CAB007753
HPA040506
MIM 604758
neXtProt NX_Q01201
PharmGKB PA34322
eggNOG NOG119056
GeneTree ENSGT00500000044765
HOGENOM HOG000148598
HOVERGEN HBG017021
InParanoid Q01201
KO K09253
OMA DDGFAYD
OrthoDB EOG7VHSWT
PhylomeDB Q01201
TreeFam TF325632
GeneWiki RELB
GenomeRNAi 5971
NextBio 23245
PRO PR:Q01201
Proteomes UP000005640
Bgee Q01201
CleanEx HS_RELB
ExpressionAtlas Q01201
Genevestigator Q01201
GO GO:0005737
GO:0005829
GO:0005815
GO:0005634
GO:0001047
GO:0003700
GO:0003714
GO:0019882
GO:0071470
GO:0032922
GO:0043011
GO:1903507
GO:0038061
GO:0010628
GO:0045063
GO:0006351
Gene3D 2.60.40.10
2.60.40.340
InterPro IPR013783
IPR014756
IPR002909
IPR000451
IPR008967
IPR011539
Pfam PF00554
PRINTS PR00057
SMART SM00429
SUPFAM SSF49417
SSF81296
PROSITE PS01204
PS50254

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032688

negative regulation of interferon-beta production

PMID:22065573[1]

ECO:0000315

P

Fig. 4

complete
CACAO 3246

GO:0005634

nucleus

PMID:22065573[1]

ECO:0000314

C

Fig. 3C

complete
CACAO 3247

part_of

GO:0017053

transcriptional repressor complex

PMID:19158276[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000451
InterPro:IPR002909
InterPro:IPR008967
InterPro:IPR011539

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q04207

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:20873783[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:20873783[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9HC98

F

Seeded From UniProt

complete

colocalizes_with

GO:0005813

centrosome

PMID:20873783[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030098

lymphocyte differentiation

PMID:26385063[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22065573[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032688

negative regulation of interferon-beta production

PMID:22065573[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04863

F

Seeded From UniProt

complete

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04863

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011274
FB:FBgn0260632
MGI:MGI:103289
PANTHER:PTN000652441
UniProtKB:Q04206
UniProtKB:Q04864

P

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
PANTHER:PTN000652441

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:727889

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:1311231

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
MGI:MGI:103290
PANTHER:PTN000652441
RGD:727889
UniProtKB:Q01201
UniProtKB:Q04206

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q01201

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
ZFIN:ZDB-GENE-040825-4

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260632
MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071470

cellular response to osmotic stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A8H1
ensembl:ENSRNOP00000054614

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A8H1
ensembl:ENSRNOP00000054614

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A8H1
ensembl:ENSRNOP00000054614

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

involved_in

GO:0045063

T-helper 1 cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

involved_in

GO:0043011

myeloid dendritic cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

F

Seeded From UniProt

complete

involved_in

GO:0042088

T-helper 1 type immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

involved_in

GO:0019882

antigen processing and presentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

F

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04863
ensembl:ENSMUSP00000092355

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011539
InterPro:IPR037059

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR030496
InterPro:IPR037059

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030496

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030496

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR037059

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030496

P

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:1577270[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:8188306[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

Reactome:R-HSA-5676590

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5607741
Reactome:R-HSA-5607731
Reactome:R-HSA-5607726
Reactome:R-HSA-5607725
Reactome:R-HSA-5607723
Reactome:R-HSA-5607720

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5660980
Reactome:R-HSA-5607741

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0002223

stimulatory C-type lectin receptor signaling pathway

Reactome:R-HSA-5621481

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page
  2. El Gazzar, M et al. (2009) Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29 1959-71 PubMed GONUTS page
  3. 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  4. 4.0 4.1 4.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page
  5. Sharfe, N et al. (2015) The effects of RelB deficiency on lymphocyte development and function. J. Autoimmun. 65 90-100 PubMed GONUTS page
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. Ruben, SM et al. (1992) I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Genes Dev. 6 745-60 PubMed GONUTS page
  8. Deloukas, P et al. (1994) The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12. Genomics 19 592-4 PubMed GONUTS page