HUMAN:RELB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RELB
Protein Name(s)	Transcription factor RelB I-Rel
External Links
UniProt	Q01201
EMBL	M83221 AF043463 AF043454 AF043455 AF043456 AF043457 AF043458 AF043459 AF043460 AF043461 AF043462 DQ314887 BC028013
CCDS	CCDS46110.1
PIR	A42617
RefSeq	NP_006500.2
UniGene	Hs.654402
ProteinModelPortal	Q01201
SMR	Q01201
BioGrid	111903
DIP	DIP-27531N
IntAct	Q01201
MINT	MINT-1131428
STRING	9606.ENSP00000221452
PhosphoSite	Q01201
DMDM	92090634
MaxQB	Q01201
PaxDb	Q01201
PRIDE	Q01201
DNASU	5971
Ensembl	ENST00000221452
GeneID	5971
KEGG	hsa:5971
UCSC	uc021uvp.1
CTD	5971
GeneCards	GC19P045504
HGNC	HGNC:9956
HPA	CAB007753 HPA040506
MIM	604758
neXtProt	NX_Q01201
PharmGKB	PA34322
eggNOG	NOG119056
GeneTree	ENSGT00500000044765
HOGENOM	HOG000148598
HOVERGEN	HBG017021
InParanoid	Q01201
KO	K09253
OMA	DDGFAYD
OrthoDB	EOG7VHSWT
PhylomeDB	Q01201
TreeFam	TF325632
GeneWiki	RELB
GenomeRNAi	5971
NextBio	23245
PRO	PR:Q01201
Proteomes	UP000005640
Bgee	Q01201
CleanEx	HS_RELB
ExpressionAtlas	Q01201
Genevestigator	Q01201
GO	GO:0005737 GO:0005829 GO:0005815 GO:0005634 GO:0001047 GO:0003700 GO:0003714 GO:0019882 GO:0071470 GO:0032922 GO:0043011 GO:1903507 GO:0038061 GO:0010628 GO:0045063 GO:0006351
Gene3D	2.60.40.10 2.60.40.340
InterPro	IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539
Pfam	PF00554
PRINTS	PR00057
SMART	SM00429
SUPFAM	SSF49417 SSF81296
PROSITE	PS01204 PS50254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032688	negative regulation of interferon-beta production	PMID:22065573^[1]	ECO:0000315			P	Fig. 4	complete CACAO 3246
	GO:0005634	nucleus	PMID:22065573^[1]	ECO:0000314			C	Fig. 3C	complete CACAO 3247
part_of	GO:0017053	transcriptional repressor complex	PMID:19158276^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000451 InterPro:IPR002909 InterPro:IPR008967 InterPro:IPR011539	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q04207	F	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:20873783^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20873783^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HC98	F	Seeded From UniProt	complete
colocalizes_with	GO:0005813	centrosome	PMID:20873783^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030098	lymphocyte differentiation	PMID:26385063^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22065573^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032688	negative regulation of interferon-beta production	PMID:22065573^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04863	F	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04863	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011274 FB:FBgn0260632 MGI:MGI:103289 PANTHER:PTN000652441 UniProtKB:Q04206 UniProtKB:Q04864	P	Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103289 PANTHER:PTN000652441	P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 RGD:727889	P	Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 RGD:1311231	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 UniProtKB:Q04206	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103289 MGI:MGI:103290 PANTHER:PTN000652441 RGD:727889 UniProtKB:Q01201 UniProtKB:Q04206	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 UniProtKB:Q01201	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 ZFIN:ZDB-GENE-040825-4	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260632 MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8H1 ensembl:ENSRNOP00000054614	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8H1 ensembl:ENSRNOP00000054614	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8H1 ensembl:ENSRNOP00000054614	F	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
involved_in	GO:0045063	T-helper 1 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	F	Seeded From UniProt	complete
involved_in	GO:0042088	T-helper 1 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
involved_in	GO:0019882	antigen processing and presentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04863 ensembl:ENSMUSP00000092355	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011539 InterPro:IPR037059	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR030496 InterPro:IPR037059	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030496	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030496	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR037059	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030496	P	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:1577270^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8188306^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	Reactome:R-HSA-5676590	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5607741 Reactome:R-HSA-5607731 Reactome:R-HSA-5607726 Reactome:R-HSA-5607725 Reactome:R-HSA-5607723 Reactome:R-HSA-5607720	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5660980 Reactome:R-HSA-5607741	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page
↑ El Gazzar, M et al. (2009) Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29 1959-71 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page
↑ Sharfe, N et al. (2015) The effects of RelB deficiency on lymphocyte development and function. J. Autoimmun. 65 90-100 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ruben, SM et al. (1992) I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Genes Dev. 6 745-60 PubMed GONUTS page
↑ Deloukas, P et al. (1994) The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12. Genomics 19 592-4 PubMed GONUTS page

[PMID:22065573-1] 1.0 ^1.1 ^1.2 ^1.3 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page

[PMID:19158276-2] El Gazzar, M et al. (2009) Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29 1959-71 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:20873783-4] 4.0 ^4.1 ^4.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page

[PMID:26385063-5] Sharfe, N et al. (2015) The effects of RelB deficiency on lymphocyte development and function. J. Autoimmun. 65 90-100 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1577270-7] Ruben, SM et al. (1992) I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Genes Dev. 6 745-60 PubMed GONUTS page

[PMID:8188306-8] Deloukas, P et al. (1994) The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12. Genomics 19 592-4 PubMed GONUTS page

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HUMAN:RELB

Contents

Annotations

Notes

References

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