HUMAN:NFKB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NFKB1
Protein Name(s)	Nuclear factor NF-kappa-B p105 subunit DNA-binding factor KBF1 EBP-1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor NF-kappa-B p50 subunit
External Links
UniProt	P19838
EMBL	M55643 M58603 Z47748 Z47749 Z47750 Z47751 Z47752 Z47753 Z47754 Z47755 Z47734 Z47735 Z47736 Z47737 Z47738 Z47739 Z47740 Z47741 Z47742 Z47743 Z47744 AF213884 AK122850 AK291450 CR749522 AY223820 BC033210 BC051765
CCDS	CCDS3657.1 CCDS54783.1
PIR	A37867
RefSeq	NP_001158884.1 NP_003989.2
UniGene	Hs.618430
PDB	1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT
PDBsum	1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT
ProteinModelPortal	P19838
SMR	P19838
BioGrid	110857
DIP	DIP-106N
IntAct	P19838
MINT	MINT-85658
STRING	9606.ENSP00000226574
BindingDB	P19838
ChEMBL	CHEMBL2094258
DrugBank	DB00945 DB01411 DB01041 DB08814
PhosphoSite	P19838
DMDM	21542418
MaxQB	P19838
PaxDb	P19838
PRIDE	P19838
DNASU	4790
Ensembl	ENST00000226574 ENST00000394820 ENST00000505458 ENST00000600343
GeneID	4790
KEGG	hsa:4790
UCSC	uc011cep.2 uc011ceq.2 uc011cer.2
CTD	4790
GeneCards	GC04P103422
HGNC	HGNC:7794
HPA	CAB004031 HPA027305
MIM	164011
neXtProt	NX_P19838
PharmGKB	PA248
eggNOG	COG0666
GeneTree	ENSGT00500000044765
HOGENOM	HOG000004822
HOVERGEN	HBG052613
InParanoid	P19838
KO	K02580
OMA	PGYGFPH
OrthoDB	EOG7W154S
PhylomeDB	P19838
TreeFam	TF325632
Reactome	REACT_118563 REACT_118656 REACT_12555 REACT_13443 REACT_13696 REACT_163994 REACT_169168 REACT_21281 REACT_22442 REACT_23950 REACT_24969 REACT_27161
SignaLink	P19838
ChiTaRS	NFKB1
EvolutionaryTrace	P19838
GeneWiki	NFKB1
GenomeRNAi	4790
NextBio	18454
PMAP-CutDB	P19838
PRO	PR:P19838
Proteomes	UP000005640
Bgee	P19838
CleanEx	HS_NFKB1
ExpressionAtlas	P19838
Genevestigator	P19838
GO	GO:0005737 GO:0005829 GO:0033256 GO:0005739 GO:0005654 GO:0005634 GO:0003690 GO:0000975 GO:0003700 GO:0008134 GO:0044212 GO:0000976 GO:0006915 GO:0071347 GO:0071354 GO:0071222 GO:0071260 GO:0071316 GO:0071375 GO:0038095 GO:0006954 GO:0045087 GO:0031293 GO:0002755 GO:0002756 GO:0043066 GO:0010956 GO:0032269 GO:0032375 GO:0050728 GO:0045083 GO:0000122 GO:0010957 GO:0048011 GO:0090263 GO:1900127 GO:0010884 GO:0010744 GO:2000630 GO:0051092 GO:0045944 GO:0045893 GO:0032481 GO:0046688 GO:0006979 GO:0050852 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0006366 GO:0035666
Gene3D	1.10.533.10 1.25.40.20 2.60.40.10 2.60.40.340
InterPro	IPR002110 IPR020683 IPR011029 IPR000488 IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539
Pfam	PF00023 PF12796 PF00531 PF00554
PRINTS	PR01415 PR00057
SMART	SM00248 SM00005 SM00429
SUPFAM	SSF47986 SSF48403 SSF49417 SSF81296
PROSITE	PS50297 PS50088 PS01204 PS50254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000451 InterPro:IPR002909 InterPro:IPR008967 InterPro:IPR011539	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25411248^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q04207	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:26687115^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000226380)	Seeded From UniProt	complete
enables	GO:0042805	actinin binding	PMID:25411248^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43707	F	occurs_in:(GO:0005634) occurs_in:(CL:0000653)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18212740^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q04206)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:1406630^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1406630^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:1406630^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000630	positive regulation of miRNA metabolic process	PMID:22357537^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071316) occurs_in:(CL:0002539)\|part_of(GO:0071354) occurs_in:(CL:0002539)\|part_of(GO:1904385) occurs_in:(CL:0002539)	Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	PMID:22357537^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002539)	Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	PMID:22357537^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002539)	Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:12958148^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	PMID:22357537^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002539)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16938301^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032375	negative regulation of cholesterol transport	PMID:16938301^[8]	ECO:0000305	curator inference used in manual assertion	GO:0005634	P		Seeded From UniProt	complete
involved_in	GO:0032269	negative regulation of cellular protein metabolic process	PMID:16938301^[8]	ECO:0000305	curator inference used in manual assertion	GO:0005634	P		Seeded From UniProt	complete
involved_in	GO:0010957	negative regulation of vitamin D biosynthetic process	PMID:15243130^[9]	ECO:0000305	curator inference used in manual assertion	GO:0010956	P		Seeded From UniProt	complete
involved_in	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	PMID:15243130^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:16938301^[8]	ECO:0000305	curator inference used in manual assertion	GO:0005634	P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:16938301^[8]	ECO:0000305	curator inference used in manual assertion	GO:0005634	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16938301^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16938301^[8]	ECO:0000305	curator inference used in manual assertion	GO:0005634	P		Seeded From UniProt	complete
involved_in	GO:1900127	positive regulation of hyaluronan biosynthetic process	PMID:17324121^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002620)\|occurs_in:(CL:0000312)	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:20018240^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20018240^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17426251^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:8096091^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11819787^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11819787^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17426251^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:18718911^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q12794)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17426251^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19881551^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P09467)	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7959007^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19955433^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18270204^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:24434510^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:7959007^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24434150^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9GZV1	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21988832^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12832462^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12482991^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071359	cellular response to dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
involved_in	GO:0045083	negative regulation of interleukin-12 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	F		Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	F		Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25799 ensembl:ENSMUSP00000029812	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011539 InterPro:IPR037059	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR030503 InterPro:IPR037059	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030503	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030503	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR037059	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030503	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000488	P		Seeded From UniProt	complete
enables	GO:0001225	RNA polymerase II transcription coactivator binding	PMID:23811396^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:23811396^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0045944) has_input:(ENSEMBL:ENSG00000089250)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23811396^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F	part_of:(GO:0018394) occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23811396^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000089250) part_of:(GO:0038061)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:23811396^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:1901224) part_of:(GO:0045944) has_input:(ENSEMBL:ENSG00000089250)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18045535^[29]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q04206)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:1992489^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033256	I-kappaB/NF-kappaB complex	PMID:16938301^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10811897^[31] Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:1992489^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:1992489^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	Reactome:R-HSA-450294	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:R-HSA-445989	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-1834949	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:R-HSA-193692	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9604480 Reactome:R-HSA-5684275 Reactome:R-HSA-5684273 Reactome:R-HSA-5684267 Reactome:R-HSA-5684261 Reactome:R-HSA-5684250 Reactome:R-HSA-5684248 Reactome:R-HSA-5607728 Reactome:R-HSA-5607724 Reactome:R-HSA-5228811 Reactome:R-HSA-451634 Reactome:R-HSA-2730894 Reactome:R-HSA-209125 Reactome:R-HSA-209063 Reactome:R-HSA-209061 Reactome:R-HSA-202541 Reactome:R-HSA-193705 Reactome:R-HSA-193700 Reactome:R-HSA-193691 Reactome:R-HSA-168166 Reactome:R-HSA-168140 Reactome:R-HSA-1168643 Reactome:R-HSA-1168642 Reactome:R-HSA-1168640 Reactome:R-HSA-1168638 Reactome:R-HSA-1168633	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9604480 Reactome:R-HSA-8865237 Reactome:R-HSA-5660666 Reactome:R-HSA-5660660 Reactome:R-HSA-5624473 Reactome:R-HSA-3857308 Reactome:R-HSA-3857305 Reactome:R-HSA-2730894 Reactome:R-HSA-193691 Reactome:R-HSA-168166 Reactome:R-HSA-1168633	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798749 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
	GO:0035525	NF-kappaB p50/p65 complex	PMID:24457827^[32]	ECO:0000314			C		Figure 2A-C shows that in cells exposed to arsentite, subunit p50 inhibits degradation of the C-Myc protein. In the absense of subunit p50, C-Myc protein levels were unstable.	complete CACAO 9242
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 Zhao, X et al. (2015) α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J. Biol. Chem. 290 338-49 PubMed GONUTS page
↑ Le, LT et al. (2016) The microRNA-29 family in cartilage homeostasis and osteoarthritis. J. Mol. Med. 94 583-96 PubMed GONUTS page
↑ Ramsey, CS et al. (2008) Copine-I represses NF-kappaB transcription by endoproteolysis of p65. Oncogene 27 3516-26 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kunsch, C et al. (1992) Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol. Cell. Biol. 12 4412-21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Maegdefessel, L et al. (2012) MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med 4 122ra22 PubMed GONUTS page
↑ Jung, YJ et al. (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17 2115-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Ferreira, V et al. (2007) Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 192 283-90 PubMed GONUTS page
↑ ^9.0 ^9.1 Ebert, R et al. (2004) Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol. Endocrinol. 18 2440-50 PubMed GONUTS page
↑ Li, L et al. (2007) Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem. J. 404 327-36 PubMed GONUTS page
↑ ^11.0 ^11.1 Medici, D & Nawshad, A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol. 29 161-5 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Cleynen, I et al. (2007) HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol. Cancer Res. 5 363-72 PubMed GONUTS page
↑ Sun, SC et al. (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259 1912-5 PubMed GONUTS page
↑ ^15.0 ^15.1 Guo, SP et al. (2001) Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus. World J. Gastroenterol. 7 340-4 PubMed GONUTS page
↑ Lokeshwar, VB et al. (2008) Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter. J. Biol. Chem. 283 29215-27 PubMed GONUTS page
↑ Liu, X et al. (2010) Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. Oncogene 29 442-50 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^19.0 ^19.1 Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page
↑ Journiac, N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc. Natl. Acad. Sci. U.S.A. 106 21365-70 PubMed GONUTS page
↑ Minami, M et al. (2008) Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J. Biol. Chem. 283 9692-703 PubMed GONUTS page
↑ Bean, C et al. (2014) Ankrd2 is a modulator of NF-κB-mediated inflammatory responses during muscle differentiation. Cell Death Dis 5 e1002 PubMed GONUTS page
↑ Verebová, V et al. (2014) Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem. Biophys. Res. Commun. 444 50-5 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page
↑ Beinke, S et al. (2003) NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity. Mol. Cell. Biol. 23 4739-52 PubMed GONUTS page
↑ Lang, V et al. (2003) betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 23 402-13 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 Li, Y et al. (2013) Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells. Neuroscience 248 681-9 PubMed GONUTS page
↑ Wan, F et al. (2007) Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 131 927-39 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Meyer, R et al. (1991) Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. Proc. Natl. Acad. Sci. U.S.A. 88 966-70 PubMed GONUTS page
↑ Cahir-McFarland, ED et al. (2000) NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells. Proc. Natl. Acad. Sci. U.S.A. 97 6055-60 PubMed GONUTS page
↑ Huang, H et al. (2014) NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. Oncotarget 5 493-505 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25411248-2] 2.0 ^2.1 Zhao, X et al. (2015) α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J. Biol. Chem. 290 338-49 PubMed GONUTS page

[PMID:26687115-3] Le, LT et al. (2016) The microRNA-29 family in cartilage homeostasis and osteoarthritis. J. Mol. Med. 94 583-96 PubMed GONUTS page

[PMID:18212740-4] Ramsey, CS et al. (2008) Copine-I represses NF-kappaB transcription by endoproteolysis of p65. Oncogene 27 3516-26 PubMed GONUTS page

[PMID:1406630-5] 5.0 ^5.1 ^5.2 Kunsch, C et al. (1992) Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol. Cell. Biol. 12 4412-21 PubMed GONUTS page

[PMID:22357537-6] 6.0 ^6.1 ^6.2 ^6.3 Maegdefessel, L et al. (2012) MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med 4 122ra22 PubMed GONUTS page

[PMID:12958148-7] Jung, YJ et al. (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17 2115-7 PubMed GONUTS page

[PMID:16938301-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Ferreira, V et al. (2007) Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 192 283-90 PubMed GONUTS page

[PMID:15243130-9] 9.0 ^9.1 Ebert, R et al. (2004) Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol. Endocrinol. 18 2440-50 PubMed GONUTS page

[PMID:17324121-10] Li, L et al. (2007) Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem. J. 404 327-36 PubMed GONUTS page

[PMID:20018240-11] 11.0 ^11.1 Medici, D & Nawshad, A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol. 29 161-5 PubMed GONUTS page

[PMID:19593445-12] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:17426251-13] 13.0 ^13.1 ^13.2 Cleynen, I et al. (2007) HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol. Cancer Res. 5 363-72 PubMed GONUTS page

[PMID:8096091-14] Sun, SC et al. (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259 1912-5 PubMed GONUTS page

[PMID:11819787-15] 15.0 ^15.1 Guo, SP et al. (2001) Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus. World J. Gastroenterol. 7 340-4 PubMed GONUTS page

[PMID:18718911-16] Lokeshwar, VB et al. (2008) Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter. J. Biol. Chem. 283 29215-27 PubMed GONUTS page

[PMID:19881551-17] Liu, X et al. (2010) Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. Oncogene 29 442-50 PubMed GONUTS page

[PMID:23776175-18] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:7959007-19] 19.0 ^19.1 Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page

[PMID:19955433-20] Journiac, N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc. Natl. Acad. Sci. U.S.A. 106 21365-70 PubMed GONUTS page

[PMID:18270204-21] Minami, M et al. (2008) Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J. Biol. Chem. 283 9692-703 PubMed GONUTS page

[PMID:24434510-22] Bean, C et al. (2014) Ankrd2 is a modulator of NF-κB-mediated inflammatory responses during muscle differentiation. Cell Death Dis 5 e1002 PubMed GONUTS page

[PMID:24434150-23] Verebová, V et al. (2014) Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem. Biophys. Res. Commun. 444 50-5 PubMed GONUTS page

[PMID:25609649-24] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:21988832-25] Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

[PMID:12832462-26] Beinke, S et al. (2003) NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity. Mol. Cell. Biol. 23 4739-52 PubMed GONUTS page

[PMID:12482991-27] Lang, V et al. (2003) betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 23 402-13 PubMed GONUTS page

[PMID:23811396-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 Li, Y et al. (2013) Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells. Neuroscience 248 681-9 PubMed GONUTS page

[PMID:18045535-29] Wan, F et al. (2007) Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 131 927-39 PubMed GONUTS page

[PMID:1992489-30] 30.0 ^30.1 ^30.2 Meyer, R et al. (1991) Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. Proc. Natl. Acad. Sci. U.S.A. 88 966-70 PubMed GONUTS page

[PMID:10811897-31] Cahir-McFarland, ED et al. (2000) NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells. Proc. Natl. Acad. Sci. U.S.A. 97 6055-60 PubMed GONUTS page

[PMID:24457827-32] Huang, H et al. (2014) NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. Oncotarget 5 493-505 PubMed GONUTS page

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HUMAN:NFKB1

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